Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound   Target Concepts: Gene/Protein Disease Symptom Drug Enzyme Compound

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Query: UMLS:C0233565 (bradykinesia)
2,352 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .

Human Gene/Protein Sep 149 MRI 116 tyrosine hydroxylase 64 synuclein 52 She 51 Mol 46 alpha-synuclein 39 dopamine transporter 35 olfactory 32 CIT 29 Pol 22 LRRK2 22 asymmetrical 21 GABA 21 DBS 21 ubiquitin 20 STN 20 axonal 19 caspase-3 17 MAO-B 17 MDS 16 parkin 14 tau protein 13 PSP 12 CSF 12 glial cell line-derived neurotrophic factor 12 REM 11 PINK1 10 tap 10 SNCA 10 Bcl-2 10 DJ-1 10 ATP 9 with Parkinsonism 9 MPP 9 proteasome 9 leucine-rich repeat kinase 2 9 catechol-O-methyltransferase 8 SCH 8 MSA 8 dopa decarboxylase 8 COMT 8 DAT 7 gut 7 ACS 7 ANOVA 7 glial fibrillary acidic protein 7 PARK7 7 5-HT1A 7 Parkin 7 endoplasmic reticulum 6 ATP13A2 6 superoxide dismutase 6 substance P 6 ferritin 6 beta-endorphin 6 ceruloplasmin 6 GSH 6 dopa-responsive dystonia 6 dopamine D2 receptor 6 glucocerebrosidase 6 DRD2 5 ATPase 5 prolactin 5 vesicular monoamine transporter 2 5 PTEN 5 FDG 5 acetylcholinesterase 5 lipopolysaccharide 5 ADL 5 sit 5 glutamic acid decarboxylase 5 methyltransferase 5 cytochrome c 5 amyloid precursor protein 5 cage 4 Hallervorden-Spatz syndrome 4 5-HT2A 4 PANK2 4 SMA 4 Dopamine transporter 4 HT3 4 catalase 4 GTP 4 p38 4 SOD2 4 ECD 4 neurotrophic factor 4 Nrf2 4 5-HT6 4 Gen 4 CBD 4 p53 4 huntingtin 4 D2 dopamine receptor 4 insulin 4 DCI 4 X-linked 4 Kufor-Rakeb syndrome 4 nitric oxide synthase 3 novel gene 3 SCA1 3 IMP 3 JAMA 3 cytochrome 3 spinocerebellar ataxia type 2 3 prion 3 glutathione peroxidase 3 TATA-binding protein 3 PARK8 3 SCA3 3 GDNF 3 NMDA receptor 3 VIM 3 PrP 3 nicotinic acetylcholine receptor 3 jerky 3 5-hydroxytryptamine 3 CREB 3 HO-1 3 14-3-3 protein 3 PI3K 3 SCA2 3 brain-derived neurotrophic factor 3 inducible nitric oxide synthase 3 reserved 3 pantothenate kinase 3 heme oxygenase-1 3 SOD 3 caspase-9 3 calpain 3 PARKIN 3 5-HT receptor 3 prion protein 3 MRS 3 TDP-43 3 catechol O-methyltransferase 3 alpha synuclein 2 San 2 SLC6A3 2 ABS 2 GAD 2 UCHL1 2 iron regulatory protein 2 2 progranulin 2 Wilson disease 2 IRP1 2 PARK6 2 Mot 2 PKA 2 ART 2 metabotropic glutamate receptor 2 frataxin 2 ERK1 2 nodal 2 fused 2 Del 2 MYC 2 phosphodiesterase 2 IL-6 2 more...

Disease Parkinson's disease 1684 parkinsonism 526 dementia 226 akinesia 175 dyskinesia 174 depression 166 movement disorder 122 cognitive impairment 122 Alzheimer's disease 106 progressive supranuclear palsy 89 Huntington's disease 76 psychosis 65 hallucinations 48 apraxia 43 dysphagia 38 sleep disorders 31 sleep disturbances 30 stroke 28 catalepsy 27 Dementia with Lewy bodies 24 neurological disease 22 encephalopathy 22 schizophrenia 21 incontinence 21 encephalitis 20 REM sleep behavior disorder 18 epilepsy 18 hemiparkinsonism 16 MDS 16 myelodysplastic syndrome 16 confusion 14 hemiparesis 14 mutism 14 disorientation 14 Wilson's disease 14 abnormal involuntary movements 13 diabetes 13 delusions 13 memory impairment 13 tardive dyskinesia 13 pneumonia 13 amyotrophic lateral sclerosis 13 PSP 12 hydrocephalus 12 coma 12 aphasia 12 dysautonomia 12 disinhibition 11 incontinence 10 pseudobulbar palsy 10 hypertension 10 tumor 10 mental illness 10 brain atrophy 10 Dystonia 10 aspiration pneumonia 9 restless legs syndrome 9 Creutzfeldt-Jakob disease 9 Multiple system atrophy 8 SCH 8 aggression 8 nystagmus 8 MSA 8 systemic lupus erythematosus 8 multiple sclerosis 7 Brown 7 olivopontocerebellar atrophy 7 immunodeficiency 7 choreoathetosis 7 major depressive disorder 7 Machado-Joseph disease 7 ischemia 7 Corticobasal degeneration 6 PAF 6 camptocormia 6 GSH 6 sexual dysfunction 6 leukoencephalopathy 6 muscular atrophy 6 vascular disease 6 Japanese encephalitis 6 HIV 6 intellectual impairment 6 Hallervorden-Spatz disease 6 neuroblastoma 6 degenerative disease 6 motor neuron disease 6 Tourette syndrome 6 behavior disorder 6 motor aphasia 5 impulse control disorder 5 plaque 5 amnesia 5 anemia 5 agnosia 5 fits 5 suicide 5 drug withdrawal 5 cold 5 brain tumor 5 Essential tremor 5 peripheral neuropathy 5 lupus 5 chronic disease 4 sleep apnea 4 Pick's disease 4 hepatic encephalopathy 4 impotence 4 Spinocerebellar ataxia 4 neurogenic bladder 4 Binswanger 4 seborrheic dermatitis 4 sensory disturbance 4 anarthria 4 prolapse 4 Cerebellum 4 lupus 4 delirium 4 virus infection 4 vasculitis 4 meningioma 4 NMS 4 melanoma 4 primary central nervous system lymphoma 4 autoimmune disease 4 tic 4 herpes simplex 4 cardiovascular disease 4 infectious diseases 4 erectile dysfunction 4 cancer 4 Vascular parkinsonism 4 toxoplasmosis 3 DM1 3 Secondary parkinsonism 3 myocardial infarction 3 Frontotemporal dementia 3 B-cell lymphoma 3 cirrhosis 3 cerebral ischemia 3 myelitis 3 polyneuropathy 3 anomia 3 cerebellar syndrome 3 malnutrition 3 PARK8 3 obsessive-compulsive disorder 3 CTX 3 Globus 3 PARK7 3 obstructive sleep apnea 3 MRS 3 stereotypies 3 encephalomyelitis 3 iron deficiency 3 Gaucher disease 3 SCA2 3 SCA1 3 CAA 3 PML 3 more...

Symptom bradykinesia 2352 tremor 1251 dystonia 167 muscle rigidity 93 ataxia 69 dysarthria 67 chorea 51 motor symptom 47 myoclonus 39 pain 38 weakness 33 seizures 32 constipation 29 apathy 28 abnormal gait 28 sleepiness 27 fatigue 25 spasticity 24 cerebellar ataxia 22 insomnia 20 nausea 17 memory loss 14 ophthalmoplegia 13 Rest tremor 12 headache 12 agitation 12 vomiting 11 Extrapyramidal symptoms 10 Decreased activity 8 dizziness 8 blepharospasm 8 paraparesis 7 clumsiness 7 hypertonia 7 anesthesia 7 incoordination 7 catatonia 7 paresis 7 dyspnea 6 drooling 6 Involuntary Movement 6 functional recovery 6 pallor 6 discomfort 5 ataxic gait 5 discomfort 5 hypothermia 5 anorexia 4 anosmia 4 torticollis 4 paresthesia 4 lethargy 4 excessive sweating 4 muscle stiffness 4 personality change 3 nausea and vomiting 3 thinning 3 eds 3 consciousness disturbance 3 hypotonia 3 stridor 3 dysuria 3 fasciculation 3 forgetfulness 3 athetosis 3 vertigo 3 myalgia 3 Sedation 2 cachexia 2 tonic-clonic seizure 2 muscle cramps 2 Postural tremor 2 cough 2 diarrhea 2 spasm 2 numbness 2 syncope 2 exhaustion 2 respiratory distress 2 urinary frequency 2 asthenia 2 asterixis 2 back pain 2 hemiplegia 2 low back pain 2 intention tremor 2 partial seizure 1 wheezing 1 decreased appetite 1 thirsty 1 leg pain 1 skin irritation 1 retching 1 knee pain 1 bloating 1 epigastric pain 1 hemihypesthesia 1 abnormal reflex 1 Lower urinary tract symptoms 1 aphagia 1 Kayser-Fleischer ring 1 Depressive symptoms 1 Parkinsonian rest tremor 1 nasal discharge 1 distraction 1 lassitude 1 Psychiatric symptoms 1 cyanosis 1 impaired body balance 1 abdominal pain 1 snoring 1 Marked rigidity 1 neurological disability 1 Freezing phenomenon 1 Ill 1 Fluctuation 1 waxy flexibility 1 Parkinsonian tremor 1 Antecollis 1 Fine tremor 1 aphonia 1 blurred vision 1 auditory hallucination 1 tachypnea 1 visual hallucination 1 oliguria 1 shortness of breath 1 hypersomnia 1 disturbed balance 1 tingling 1 analgesia 1 Fear of falling 1 collapse 1 Fear of falling 1 stigma 1 Motor dysfunction 1 neck pain 1 prostration 1 dysesthesia 1 Behavioral symptoms 1 arm weakness 1 Extrapyramidal rigidity 1 adipsia 1 twitching 1 orofacial pain 1 Cog-wheel rigidity 1

Drug DBS 21 Sinemet 18 MDS 16 Sinemet 15 Sinemet 15 CSF 12 Parkin 7 Posture 7 Parkin 7 Apomorphine 6 Madopar 4 Parlodel 4 caffeine 4 vitamin E 3 Parlodel 3 ascorbate 3 Lisuride 3 Frontal 3 Carbidopa 3 Rasagiline 3 Lergotrile 2 Blonanserin 2 CFT 2 niacin 2 ICI 2 ROS 2 Portal 2 Benserazide 2 Lergotrile mesylate 1 Bupleurum root 1 TMS 1 Android 1 Tianma 1 Pramipexole 1 Pramipexole 1 MAP 1 CTX 1 citric acid 1 Tocopherol 1 NADH 1 Dophamine 1 Azilect 1 3,4-Dihydroxyphenylalanine 1 Spectrum 1 Dakar 1 Triclosan 1 Flunarizine hydrochloride 1 CTX 1 Primperan 1 Succinobucol 1 CTX 1 Rosin 1 DM1 1 Sodium benzoate 1 Eldepryl 1 Reserpine 1 Topamax 1 Istradefylline 1 Metoclopramide hydrochloride 1 HCG 1 Safflower 1 Tandospirone citrate 1 ENT 1 Monit 1 uPA 1 Diurnal 1 Droxidopa 1 PCP 1 Eldepryl 1 Mirapex 1 Bupivacaine 1 NVP 1 Moclobemide 1 ROC 1 pyridoxal phosphate 1 Donepezil 1

Enzyme tyrosine hydroxylase 63 monoamine oxidase 28 caspase-3 17 acetylcholinesterase 10 proteasome 10 superoxide dismutase 9 MPP 9 protein kinase 7 ACS 7 DAT 7 ceruloplasmin 6 complex I 6 mitogen-activated protein kinase 6 cholinesterase 6 catalase 5 ERK 5 ATPase 5 pantothenate kinase 4 caspase-9 3 DOPA decarboxylase 3 glutathione peroxidase 3 catechol O-methyltransferase 3 heme oxygenase 3 phosphodiesterase 2 AMPK 2 protein kinase C 2 peroxidase 2 beta-galactosidase 2 choline acetyltransferase 2 GSK 2 AMPK 2 AMP-activated protein kinase 2 FAST 1 glutathione reductase 1 MAP 1 MEK 1 lactate dehydrogenase 1 phosphatidylinositol 3-kinase 1 NADPH oxidase 1 hexosaminidase 1 aldehyde dehydrogenase 1 isopeptidase 1 creatine kinase 1 CD10 1 proteinase K 1 phosphoglycerate kinase 1 PCP 1 glyceraldehyde-3-phosphate dehydrogenase 1 P-glycoprotein 1 tissue plasminogen activator 1 succinate dehydrogenase 1 cathepsin B 1 paraoxonase 1 guanylate cyclase 1 PKG 1 urokinase-type plasminogen activator 1 calcineurin 1 NOS 1 transglutaminase 1 nicotinamide N-methyltransferase 1 granzyme B 1 cyclohydrolase 1 PAL 1 papain 1 PDE 1 GD3 synthase 1 GABA transaminase 1 PAL 1 Thy1 1 MEKK1 1 PARP 1 myrosinase 1 paraoxonase 1 NADPH oxidase 1 Alternating 1 aldehyde oxidase 1 CNPase 1 glucocerebrosidase 1

Compound L-DOPA 161 Dec 153 Clin 140 MPTP 135 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 86 Dopamine 41 His 35 glutamate 31 CIT 29 CIT 29 oxygen 27 manganese 26 iron 23 GABA 21 GABA 21 DBS 21 water 19 DNA 18 calcium 17 5-HT 16 Dopa 14 noradrenaline 13 glucose 13 Neuronal 12 PSP 12 4-phenyl-1,2,3,6-tetrahydropyridine 11 Bromocriptine 10 MPP 9 MPP 9 ATP 9 nitric oxide 9 potassium 8 PDQ 8 gamma-aminobutyric acid 7 DAT 7 copper 7 NMDA 7 ACS 7 ACS 7 Haloperidol 6 GSH 6 GSH 6 Haloperidol 6 cAMP 6 DSM 6 iodine 5 sodium 5 Rotenone 5 Amantadine 5 Amantadine 5 caffeine 5 3,4-dihydroxyphenylalanine 5 Amantadine 5 tyrosine 5 Amantadine 5 ethanol 5 galactose 4 silver 4 cysteine 4 sulfate 4 DCI 4 Ropinirole 4 GTP 4 Nicotine 4 Selegiline 4 Letter 3 HCl 3 arginine 3 alanine 3 methanol 3 serine 3 CO2 3 IMP 3 valine 3 HVA 3 mercury 3 Morphine 3 Pergolide 3 1,2,3,4-tetrahydroisoquinoline 3 cyanide 3 methionine 3 creatinine 3 nitrogen 3 MDA 3 acetic acid 3 coenzyme Q10 3 TAR 3 aspartic acid 2 1,3-dihydro-2H-benzimidazol-2-one 2 glutamine 2 cGMP 2 Optimal 2 glutamic acid 2 Quetiapine 2 Ubiquitin 2 AMPA 2 4-chlorophenyl 2 Glutamate 2 tungsten 2 NOP 2 hydroxyindoleacetic acid 2 Formal 2 DOPAC 2 ICI 2 Coronal 2 Off 2 1-benzyl-1,2,3,4-tetrahydroisoquinoline 2 aspartic acid 2 leucine 2 Adenosine 2 Olanzapine 2 aspartic acid 2 Valproic acid 2 PEG 2 Isatin 2 aspartic acid 2 A 71 2 neopterin 2 TDP 2 GM1 2 acetate 2 Resveratrol 2 hydrogen 2 5-HIAA 2 Methylphenidate 2 A 1 2 Phe 2 5-hydroxytryptophan 2 Cereb 2 4-chlorophenyl 2 MHPG 2 PEG 2 CAA 2 MTT 2 Asp 2 hydroxytyramine 1 ammonia 1 isoxazole 1 Carvacrol 1 benzaldehyde 1 Bupivacaine 1 isoleucine 1 silicon 1 cyclohexanecarboxylic acid 1 Reserpine 1 nicotinamide 1 nicotinaldehyde 1 nicotinaldehyde 1 DDC 1 dipropyl 1 tris(2-chloropropyl) phosphate 1 H2O2 1 PAPP 1 isoleucine 1 Berberine 1 benzamide 1 nicotinaldehyde 1 1-Methyl-4-phenylpyridinium 1 MEK 1 Curcumin 1 more...

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