Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0232605 (regurgitation)
 8,217 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The aortic root as a functional unit includes the sinuses of valsalva, valve ring, the leaflets and the commissures. This unit is impaired by the insertion of a bioprosthetic three-leaflet valve. Moreover, bioprostheses fail because of fatigue and flexion stresses. Consequently a program was started for free-handed orthotopic transplantation of allogeneous aortic valves at the Department of Cardiovascular Surgery, University Kiel. A series of 16 consecutive antibiotic, sterilized aortic valve allografts were transplanted in the last 12 months without death. There were 4 females and 12 males between 18 and 63 years old (mean 47.9). The dominant lesion was aortic regurgitation (in 9), stenosis (in 3) and mixed (in 4). Out of the 13 patients who maintained their allografts, 10 (77%) were in class III and 3 (23%) in class IV of the NYHA functional classification. Four patients improved from class III to class I, and 9 from class III and IV to class II of the NYHA functional classification after surgery. All patients except one had postoperative recatheterization including videodensitometry to quantitate the regurgitation, expressed as a regurgitant fraction ( RGF ) in percent of the total stroke volume of the left ventricle, and pressure measurements to determine systolic gradients across the aortic valve allograft, 3 to 6 days and 9 months after surgery. Eleven (68.75%) patients had no regurgitation, 2 (12.5%) patients had trivial aortic regurgitation with RGF of 7% and 10%, respectively. Three (18.75%) patients had severe aortic valve regurgitation with RGF between 40% and 60% due to technical errors and their allografts had to be replaced.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Orthotopic transplantation of aortic valve allografts. Early hemodynamic results. 620 16

The accuracy of Roentgen-Videodensitometry is tested with respect to clinical applications of valvular insufficiency measurements as well as the determination of ventricular ejection fraction. For this purpose, criteria of data analysis were applied to densitometric measurements in order to provide a comparable degree of accuracy in patient studies as obtained by experimental investigations using electromagnetic flow measurements as well ventricular volume determination for comparison. 10 pigs with experimental aortic valve incompetence were studied for the analysis of 99 contrast dilution curves of the left ventricle: Accurate measurements of valvular regurgitation were obtained if the magnitude of contrast medium induced density changes was at least twice of non-specific density variations of the curves. Correlation of the according regurgitant fraction values with electromagnetic flowmeter data yielded r = 0.94, s = +/- 7.2% RGF (n = 90). Non-ideal washout of contrast medium from the ventricle was found not to be a limiting factor in these measurements. Calculation of ventricular ejection fraction by videodensitometry (n = 60) was in agreement with ventriculometry data only in half of the cases (r = 0.75, s = +/- 8.2% EF, n = 31); namely, if scattering of densitometric data of the washout part of the curves did not exceed a certain value (s = +/- 10% of highest value). This indicates the necessity of optimal indicator mixing as well as the limitations for the densitometric determination of this specific parameter.
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PMID:[Accuracy and performance of Roentgen-Videodensitometry for valvular regurgitation and ventricular ejection measurements (author's transl)]. 730 99