Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0232605 (regurgitation)
 8,217 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A number of plants are capable of producing intoxication of sufficient severity as to cause death within 12 hours of the onset of clinical signs. Those most rapid in their lethal effects are the cyanogenic plants and yew. Nitrate-accumulating plants likewise are capable of causing sudden death with only a brief appearance of signs. Most toxic plants, however, typically either require a longer time for the intoxication to develop and become lethal or sudden death is the exception rather than the rule following ingestion. In these cases, diagnosis of the problem may be facilitated by recognition of arrays of clinical signs that appear. Seven major groups of presenting signs can be distinguished: dyspnea and polypnea, hemorrhage, prominent excessive muscular activity, depression and/or weakness, diarrhea and weakness, excessive salivation and/or regurgitation and/or colic, and weakness and incoordination and/or tremors. Based on these and accompanying signs in surviving animals, many of the causes of sudden death can be differentiated. In addition, pathological changes visible on necropsy and identification of plant fragments in the rumen and stomach may be of diagnostic value.
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PMID:Plants causing sudden death in livestock. 266 7

Pharyngoesophageal diverticulum is an acquired defect resulting from an incoordination of the cricopharyngeal muscle. Common symptoms are dysphagia, regurgitation, and aspiration. The defect is repaired through a cervical incision and should include a diverticulectomy and a myotomy. Results are excellent and complications are unusual.
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PMID:Pharyngoesophageal diverticulum: technique of repair. 758 31

Zenker's diverticulum is a pouch protruding posteriorly above the upper esophageal sphincter, in the Killian's triangle, an area of relative weakness. Zenker's diverticulum was thought, for many years, to occur as a result of cricopharyngeal incoordination but more recent evidence points to poor upper sphincter compliance with diminished sphincter opening and increased hypopharyngeal pressures. Small Zenker's diverticula may be asymptomatic. As they become larger, symptoms include dysphagia, food regurgitation, and a sensation of globus. The best diagnostic method is a barium swallow with attention to the cricopharyngeal area. Although gastroesophageal reflux may be responsible for many throat symptoms, the relationship of reflux to the pathogenesis of Zenker's diverticulum is speculative. The treatment of Zenker's diverticulum is surgical. There have been many variations in technique over the years. Diverticulectomy with cricopharyngeal myotomy remains the most frequently performed operation. Endoscopic treatment with or without laser stapling has been reported but is not popular in the United States.
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PMID:Zenker's diverticulum. 961 33

The authors report their study on gastro-esophageal reflux disease, a pathology that has become increasingly common over the past years reflecting both a real increase and the use of new and more sophisticated and reliable diagnostic methods and tests. It can be included in the group of pathologies absorbing the largest proportion of financial resources, even exceeding biliary lithiasic disease according to American studies. The authors start by analysing the symptoms of gastroesophageal reflux disease, drawing a distinction between typical (heartburn, epigastric pain and postprandial regurgitation) and atypical symptoms (laryngotracheal symptoms, bronchopulmonary symptoms and esophageal motor incoordination). They outline the diagnostic iter and tests most widely used today to achieve a correct diagnosis. Lastly, they report their experience of 160 patients attending their esophageal diagnostic unit since January 1999 who underwent a number of different instrumental tests, the results of which are compared. Three different aspects are compared: the presence of symptoms, 24-hour pH-metry and endoscopic tests. All these are necessary for a correct diagnosis of gastroesophageal reflux disease and to evaluate the possibility and efficacy of surgery. They emphasise the diagnostic importance of 24-hour pH-measurement as the only test that can directly reveal gastroesophageal reflux. Positive pH results represent a discriminating element in deciding whether the patient should undergo surgery.
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PMID:[Current diagnosis of gastroesophageal reflux disease: learning experience]. 1128 76

A 14-year-old boy presented with regurgitation, malnutrition, and chronic lung insufficiency with a history of successful repair of esophageal atresia and tracheoesophageal fistula in the newborn period. Barium swallow and manometry results showed achalasia. Hellar operation with antireflux procedure resulted in complete symptomatic relief. Histology and immunohistochemistry including PGP9.5, MAP5, cKit, and nNOS of myotomy specimen showed intact innervation. Although esophageal dysmotility after esophageal atresia repair usually is caused by gastroesophageal reflux and incoordination of peristalsis, the possibility of achalasia should also be considered, because a casual relationship between esophageal atresia and achalasia may exist.
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PMID:Esophageal atresia and achalasialike esophageal dysmotility. 1548 12

Zenker's diverticulum (hypopharyngeal pouch) is a rare medical entity caused by herniation of esophageal mucosa and submucosa through an anatomical defect between the layers of the inferior constrictor muscle. It is believed that this occurs mainly due to incoordination between the stages of swallowing and timely opening of the cricopharyngeus. It usually affects the elderly and patients usually present with dysphagia, regurgitation of food, halitosis and aspiration. We describe one case of Zenker's diverticulum in a 75-year Saudi female whom we successfully managed in Ear Nose Throat (ENT) department, North West Armed Forces Hospital, Tabuk, Saudi Arabia by endoscopic staple-assisted diverticulotomy resulting in successful division of the intervening septum between the diverticulum and the esophagus. This technique was well-tolerated by the patient with early return to oral feeding and shorter hospital stay. Endoscopic staple-assisted diverticulotomy is a relatively safer technique of dealing with this problem as compared to the traditional open procedure causing more morbidity, and we advocate its use to reduce patient morbidity in selected cases.
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PMID:Successful Treatment of Zenker's Diverticulum by Endoscopic Staple-Assisted Diverticulotomy in a 75-year Saudi Female. 2905 28