Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0232487 (abdominal discomfort)
 1,724 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This is a prospective and experimental trial with the objective of treating pregnancies complicated with symptomatic polyhydramnios. Patients with pregnancies between 24 and 25 weeks, index of amniotic fluid greater than 24 and with symptoms associated to polyhydramnios such as abdominal discomfort, respiratory distress and premature uterine contractions, were entered into the trial. The medication utilized was Indomethacin 25 mg p.o. every six hours until symptoms disappear and the index of amniotic fluid was less than 24. Eight patients were treated during an eight months period. The average age was 30 years, with a rank between 25 and 37 years. There were only two nulliparous and the average gestational age was 30 weeks. The patients were classified in this way: three with idiopathic polyhydramnios, two with twin pregnancies, one with diabetes mellitus and two pregnancies, one with diabetes mellitus and two pregnancies with fetal malformations. 18 trisomy was diagnosed in the newborn from one of the patients with idiopathic polyhydramnios. The average index of amniotic fluid upon initiating the treatment was of 33.6 and 18 upon finishing. The maximum treatment time was six days with average four. Ultrasonographic control was obtained every 24 hours and fetal echocardiogram at 24 and 96 hours of treatment. There were no maternal nor fetal side effects. Success rate correcting symptomatic polyhydramnios with Indomethacin was 100%.
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PMID:[Pregnancy complicated with symptomatic polyhydramnios: treatment with indomethacin]. 907 5

We have previously shown in rats that both intrathecal and systemic analgesia regimens attenuate surgery-induced increases in tumor susceptibility. The current study used indomethacin to assess the role of prostaglandins and inflammation-associated pain in mediating the deleterious effects of surgery on immunity and tumor susceptibility. Male and female Fischer 344 rats were anesthetized with halothane and were either subjected or not to experimental laparotomy, followed by the administration of indomethacin or vehicle. Tumor susceptibility was assessed by the lung retention assay using the syngeneic MADB106 mammary adenocarcinoma cell line, a natural killer (NK)-sensitive tumor that colonizes only in the lungs. Surgery resulted in a 2- to 3.5-fold increase in lung tumor retention, and indomethacin administration significantly reduced this effect in both sexes without affecting unoperated animals. Indomethacin also attenuated the reductions in rearing behavior evident after surgery, suggesting that it relieved abdominal discomfort. Surgery increased interleukin-6 levels and suppressed NK activity per milliliter blood. Indomethacin restored NK activity in both male and female rats but attenuated surgery-induced interleukin-6 increases only in the male rats. These findings further support our previous work implicating pain in mediating the tumor-enhancing effects of surgery and implicate prostaglandins in mediating this effect. If similar relationships occur in humans, controlling postoperative pain and inflammation must become a priority in the management of cancer patients undergoing surgery.
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PMID:Indomethacin attenuates the immunosuppressive and tumor-promoting effects of surgery. 1462 54