Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0231835 (tachypnea)
 2,543 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Serum creatine kinase (CK) and creatine kinase-MB isoenzyme (CK-MB) activities were studied prospectively in serial blood samples obtained from 23 perinatally asphyxiated negroid newborns and 12 healthy controls during the first 100 h of life. The asphyxiated infants had significantly elevated mean CK and absolute CK-MB but no fractional CK-MB activities. Peak mean CK and CK-MB values (U.l-1) were 789.17 (+/- 220), P less than 0.01 and 16.36 (+/- 3.0) P less than 0.001 respectively at the 6-8 post-partum period. The healthy controls, on the other hand, showed a steady decline in the activities of these enzymes from birth. The vaginally and operatively delivered asphyxiated infants showed significantly higher CK and CK-MB activities than their respective non-asphyxiated controls, but no increase in fractional CK-MB was recorded in any of the groups. The elevation in absolute and fractional CK-MB 42.0 U.l-1 (5.1%) in respect of the infants with TTI (transient tricuspid incompetence) was significant (P less than 0.05) when compared with the controls with features of TTN (transient tachypnoea of the newborn) in the 6-8 h post-partum period. One of the infants with TTI at autopsy had hypoxic myocardial injury. The specificity of CK-MB, as a marker of myocardial injury in asphyxiated negroid neonates, is plausible but remains uncertain. Until the lack of rise of CK and CK-MB in healthy negroid newborns is confirmed in a larger series with further studies on MM, BB and MB isoenzymes, caution is urged in the interpretation of elevated CK and CK-MB activities in asphyxiated negroid newborns.
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PMID:Serum creatine kinase and creatine kinase-MB isoenzyme activities in perinatally asphyxiated newborns. 193 11

Although respiratory distress is common among African newborn infants in special care, respiratory distress syndrome, which is the commonest cause of respiratory distress in other races, has been reported as uncommon among African infants. A prospective study of 312 consecutive newborn Nigerian infants admitted to a special care unit revealed 103 (33%) with respiratory distress. In 100 cases studied there was transient tachypnoea of the newborn ( TTN ) in 40% while specific diseases such as pneumonia and septicaemia, severe aspiration syndromes and respiratory distress syndrome (RDS) accounted for 25%, 19% and 12%, respectively. TTN and RDS occurred mostly among preterm infants with moderate perinatal asphyxia while severe aspiration syndrome was found among term infants with severe birth asphyxia. The study suggests that prevention and/or improved management of perinatal asphyxia and infections should reduce the incidence and mortality associated with neonatal respiratory distress.
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PMID:Respiratory distress in a special care baby unit in Nigeria. 620 67

Childhood asthma usually begins early in life. Neonatal characteristics are reportedly predictive of symptom onset. This investigation utilized data from a provincial health organization to evaluate the effect of several birth characteristics on asthma incidence and hospitalization for asthma during age 0-4. Using logistic regression, the odds ratios (OR) for the following variables indicate a significant (p < 0.05) association with physician-diagnosed preschool asthma: male gender (OR = 1.72), birthweight < 1500 g (OR = 2.11), prematurity (OR = 1.34), respiratory distress syndrome (RDS) in the presence (OR = 2.95) or absence (OR = 1.61) of bronchopulmonary dysplasia (BPD), and transient tachypnea of the newborn (TTN; OR = 1.36). Male gender (OR = 1.91), birthweight < 1500 g (OR = 2.56), RDS with and without BPD (OR = 3.35 and 2.50, respectively), TTN (OR = 2.08), and severe birth asphyxia (OR = 1.94) showed an important association with hospitalization due to asthma. Neonatal characteristics are important determinants for the risk of preschool asthma, even after mutual adjustment.
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PMID:Neonatal characteristics as risk factors for preschool asthma. 870 80