Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0231807 (exertional dyspnea)
 3,402 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A case was reported of bilateral coronary artery-pulmonary artery fistulas associated with mitral valve stenosis. A thirty seven year old female was admitted with the complaint of exertional dyspnea and palpitation, which had lasted for the 3 years previous to her admission to our hospital. Electrocardiogram showed sinus bradycardia and no ST-T changes, but exercise ECG showed significant ST depression after 6 min of exercise. The DDR (9 mm/sec) and mitral valve area (0.61 cm2) were shown by UCG examination to have decreased, and the pressure at half time (360 msec) was shown by Doppler UCG to be prolonged. On cardiac catheterization, coronary arteriography showed fistula from RCA to PA, and fistula from LCA to PA, but no occlusive lesions were demonstrated. P/S blood flow ratio was 1.09, and O2 saturation was stepped up 3% in PA. She was operated on and given open mitral commissurotomy and closure of the fistula opening, via the PA. After surgical repair, no abnormality was found by exercise ECG, and no fistulas were shown on coronary arteriography.
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PMID:[A case of bilateral coronary artery--pulmonary artery fistulas associated with mitral valve stenosis]. 230 31

A 41-year-old woman with no modifiable coronary risk factors presented with a progressive exertional dyspnea. Chest radiography showed an enlarged cardiac silhouette with reinforced pulmonary vasculature in bilateral lower lung fields and both pleural effusion. Echocardiography revealed a dilated, globally hypokinetic left ventricle with an ejection fraction of 40%. Multislice cardiac computed tomography revealed abnormal origin of LCA from the main pulmonary artery receiving collaterals from a normally originating dilated tortuous right coronary artery. Coronary angiography revealed a single, large, and tortuous RCA arising from the right sinus of Valsalva and giving off extensive collateral vessels coursing over the right ventricular wall, the interventricular septum, and the apex to the left coronary artery that was drained into the proximal main pulmonary. The diagnosis of anomalous origin of the left coronary artery from the pulmonary artery (ALCAPA) was confirmed. The patient underwent successful reimplantation of LCA to aorta after closure of the ostium (in the main pulmonary artery) of the anomalously originating LCA. After surgical and medical treatment, the patient's symptoms were relieved and both pleural effusions were improved on chest radiography. After then, the patient was discharged on medication.
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PMID:A rare case of anomalous left coronary artery from the pulmonary artery (ALCAPA) presenting congestive heart failure in an adult. 1709 50