Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0231807 (exertional dyspnea)
 3,402 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Twelve weeks after repeated spontaneous mating between a Bentheimer Landschaf ram and a West African dwarf doe was observed, the doe aborted a dead fetus. The aim of this study was to verify the parentage and the species of the supposed parents and the hybrid status of the fetus, using cytogenetic and molecular genetic methods. For this purpose, karyotypes were prepared using fresh blood samples from the ram and the doe, and genomic DNA was extracted from blood of the suspected parents and tissue of the aborted fetus. Fragments of the nuclear DNA-encoded interleukin-2 gene and the mitochondrial DNA-encoded 16S ribosomal RNA were sequenced and 19 microsatellites were genotyped in all 3 animals. The karyotypes and DNA sequences of the ram and the doe corresponded to domestic sheep and goat, respectively. The interleukin-2 sequence of the fetus was heterozygous at all positions where sheep and goat have different nucleotides. None of the 19 microsatellites excluded the ram and the dwarf doe as parents of the fetus. Taken together, we can conclude that the ram and the dwarf doe were from the species Ovis aries and Capra hircus, respectively, and that they were most likely the parents of the aborted fetus, which itself proved to be a hybrid of these 2 species.
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PMID:Genetic characterization of a sheep-dwarf goat hybrid. 1972 20

A 68-year-old woman, suffering from dyspnea on exertion, was admitted to our hospital. She had noticed her nails become yellow 8 years previously. She had mild bilateral effusion. Examination of the pleural fluid revealed exudates which were lymphocyte-rich, a high concentration of adenosine deaminase (ADA) and elevated serum levels of soluble interleukin-2 receptors. These confirmed the diagnosis of yellow nail syndrome.
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PMID:[A case of yellow nail syndrome with bilateral pleural effusion]. 2060 92

We describe the case of a 49-year-old woman with metastatic renal carcinoma receiving treatment with high-dose interleukin-2 (IL-2) who developed acutely progressive dyspnea on exertion and an elevated troponin level. Cardiac magnetic resonance imaging (CMR) was used to establish the diagnosis of IL-2-associated cardiotoxicity, differentiating myocarditis from acute coronary syndrome (ACS) and preventing an unnecessary invasive coronary angiogram. <Learning objective: ACS and myocarditis can present with similar symptoms and elevation in troponin levels. For individuals that lack significant risk factors for coronary artery disease, cardiac CMR may be used to differentiate ACS from myocarditis and avoid unnecessary invasive testing.>.
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PMID:Acute myocarditis following high-dose interleukin-2 treatment. 3052 78