Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0231807 (exertional dyspnea)
 3,402 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The placental transfer of indomethacin was studied in the rabbit at 30 days of gestation and in the sheep between 120 and 135 days of gestation. Plasma concentrations of indomethacin reached a maximum of 13.7 +/- 1.6 and 10.9 +/- 1.5 microgram/mL in the doe and fetuses, respectively, at 1 h following a maternal subcutaneous injection of 10.0 mg/kg. The maternal plasma concentration of drug decreased rapidly but the fetal plasma concentration of drug remained elevated and exceeded that of the doe before decreasing. Indomethacin became detectable in the amniotic fluid after 2 h, reached a maximum of 3.2 +/- 0.8 microgram/mL at 4 h, and the gradually decreased. The intravenous infusion of 10.0 mg of indomethacin per kilogram over 30 min into a pregnant ewe resulted in a maximal plasma concentration of 13.5 +/- 0.7 microgram/mL in the ewe and 0.6 +/- 0.1 microgram/mL in the fetus at the termination of the infusion. The concentration of indomethacin in the amniotic fluid increased to a maximum of 3.5 +/- 0.5 microgram/mL 150 min after the infusion stopped. There was an increase in the percentage of drug bound by the fetal plasma proteins as gestation advanced. Thus, there exists the possibility that the fetus would be exposed to increasing amounts of indomethacin as term approached.
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PMID:Placental transfer of indomethacin in the rabbit and sheep. 723 50

This study has examined the effects of prostaglandins E2 and F2a (PGE2 and PGF2a) and indomethacin on cellular inflammation in fetal rabbits. Fetuses heal differently from adults: incisions heal with no scar or inflammation; excisional wounds exposed to amniotic fluid (AF) do not heal or become inflamed, and have high tissue levels of PGE2 and PGF2a; excisional wounds protected from AF do heal and become inflamed, and have low tissue PG levels. The authors inserted slow-release pellets [control, PGE2 (10 micrograms), PGF2a (10 micrograms), indomethacin (10 micrograms)] into subcutaneous pockets in fetal rabbits on day 25 of gestation (one per fetus). Pellets were also placed in subcutaneous pockets in the does. Fetuses and doe tissues were recovered 72 h after surgery. Control pellets in fetuses had a slight inflammatory response, with some cells present. Fetal PGE2 pellets had a layer 5-10 cells thick surrounding the pellet, and fetal PGF2a pellets had a 10-15-cell layer. Fetal indomethacin pellets had no response, with no inflammatory cells present. All pellets placed in does elicited a slight cellular inflammatory response, equal to that seen with control pellet in fetuses. These results show that PGE2 and PGF2a are potent in-vivo promoters of cellular inflammation in fetal rabbits, but not in adult rabbits. Indomethacin suppresses the foreign-body response in fetal rabbits, but not in adult rabbits.
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PMID:Effects of prostaglandins and indomethacin on the cellular inflammatory response following surgical trauma in fetal rabbits. 818 54