Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0231807 (exertional dyspnea)
 3,402 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The development of neuromotor patterns in relation to birth weight was studied in the rabbit, a perinatal brain developer. In order to induce intrauterine growth retardation and to increase the number of low birth weight rabbits, experimental ischemia to half the fetuses in each doe was achieved by total ligation of approximately 30% of spiral vessels to the placenta, during the last trimester of gestation. Following natural delivery, the rabbit pups were periodically observed for the appearance of eye-opening and righting reflex, and for the cessations of falling, circling and dragging of hind limbs. An index of neuromotor development was assigned to each rabbit by summing up the age (in days) of appearance of each of the neuromotor milestones. An association was found between low birth weight and delayed neuromotor development at 2 weeks of age. The most significant correlation was found between low birth weight and delayed disappearance of falling. The latter may represent incoordination as an expression of cerebellar dysfunction.
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PMID:Neuromotor development in relation to birth weight in rabbits. 56 25

The development of biochemical parameters (cellular DNA and protein) in relation to birth weight was studied in the rabbit, a perinatal brain developer. To induce intrauterine growth retardation and to increase the number of low-birth-weight rabbits, experimental ischemia, in half the fetuses of each doe, was achieved by total ligation of approximately 30% of uteroplacental vessels during the last third of gestation. Following natural delivery, the rabbit pups were raised until 60 days of age, at which time the brains were removed and dissected into cerebral hemispheres, cerebellum and brain stem. The amount of DNA (representing cell number) and protein (suggesting cell size) was estimated in each brain region. A significant correlation was found between low birth weight and reduced DNA in the cerebellum and reduced protein in the cerebral hemispheres. These persistent deficiencies could be related to some lasting handicaps, especially motor incoordination, as an expression of cerebellar dysfunction.
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PMID:Vascular-induced intrauterine growth retardation: relations between birth weight and the development of biochemical parameters in young rabbits. 407 72

The Hanford Nuclear Reservation is one of the U.S. Department of Energy's largest nuclear weapons sites. The enormous changes experienced by Hanford over the last several years, as its mission has shifted from weapons production to cleanup, has profoundly affected its occupational health and safety services. Innovative programs and new initiatives hold promise for a safer workplace for the thousands of workers at Hanford and other DOE sites. However, occupational health and safety professionals continue to face multiple organizational, economic, and cultural challenges. A major problem identified during this review was the lack of coordination of onsite services. Because each health and safety program operates independently (albeit with the guidance of the Richland field operations office), many services are duplicative and the health and safety system is fragmented. The fragmentation is compounded by the lack of centralized data repositories for demographic and exposure data. Innovative measures such as a questionnaire-driven Employee Job Task Analysis linked to medical examinations has allowed the site to move from the inefficient and potentially dangerous administrative medical monitoring assignment to defensible risk-based assignments and could serve as a framework for improving centralized data management and service delivery.
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PMID:Barriers and solutions in implementing occupational health and safety services at a large nuclear weapons facility. 1118 38