Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0231749 (knee pain)
 2,815 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

In 21 patients with "spontaneous" knee pain, 99mTc-MDP bone scan was found to be more sensitive than clinical and radiographic examination in detecting alterations of the joint components. These alterations were shown by increased radionuclide uptake in the compartments where pain was present, which was most commonly the medial femorotibial compartment, although the femoropatellar compartment was also frequently affected. The authors conclude that bone scan should be the first imaging study performed on the knee in order to establish if further tests are necessary.
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PMID:Bone scan features in spontaneous knee pain. 128 87

Three-phase scintimetry with 99mTc MDP was analyzed in 40 patients with a clinical history of spontaneous onset of knee pain and a focal static isotope uptake in the femoral condyle indicating osteonecrosis. A strong correlation was found between pool-phase ratios and the static ratios. The pool-phase study did not add to the information obtained from the flow phase and static studies. There was a characteristic change of the pattern of the early flow-phase curves with the duration since the onset of symptoms indicating hyperemia early in the disease. A persistent high flow-phase and static-uptake ratio 6-12 months after the onset of symptoms correlated positively with a poor clinical and radiographic outcome. The 10 patients with a good prognosis had, as a group, a more rapid decrease in isotope uptake after 6 months. There was a positive correlation between a high static uptake ratio and the size of the lesion, and subsequently with the clinical and radiographic outcome. 30 patients developed arthrosis and/or severe clinical symptoms. Five of the 10 patients who did not develop arthrosis never developed radiographic evidence of osteonecrosis.
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PMID:Three-phase scintimetry in osteonecrosis of the knee. 236 Apr 27

A 64-year-old man with right knee pain had uptake of Tc-99m MDP in the area as well as in the greater trochanter. Both sites were shown to contain osteogenic sarcoma. There was resection of the bone. Eight months later, radiogallium uptake was avid in the nearby soft tissue, indicating tumor spread.
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PMID:Multifocal osteogenic sarcoma in the seventh decade. 345 63

Erdheim-Chester disease (E-C D) is a rare clinicopathologic entity with nearly pathognomonic radiographic features. About half of the affected exhibit extraskeletal manifestations, including involvement of the hypothalamus-pituitary axis, lung, heart, retroperitoneum, skin, liver, kidneys, spleen and orbit. This disease usually affects individuals in their fifties to their seventies and has a male preponderance. The lesions of E-C D consist of lipid-storing CD68 (+) and CD1a (-) non-Langerhans cell histiocytes, either localized to the bone or involving multiple systems of the body as well. Skeletal involvement is characteristically bilateral and symmetric, exhibiting an osteosclerotic pattern in the metaphysis and diaphysis of the long bones, usually sparing epiphysis. We recently had a 68 years old male patient with E-C D, with a mild and persistent knee pain, who was subjected to a 3-phase technetium-99m methylene diphosphonate ((99m)Tc-MDP) bone-scan and subsequently to gallium-67 citrate ((67)Ga-C) whole body scan. The characteristic symmetric pattern of these scans raised the question of E-CD disease. The patient showed an excellent symptomatic response to high-dose steroids. However, the symptoms recurred after discontinuation of treatment.
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PMID:Erdheim-Chester disease: symmetric uptake in the (99m)Tc-MDP bone scan. 2041 Nov 79