Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0231530 (twitching)
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Human Gene/Protein
tfp 12.2
Chp 11.7
APSS 10.2
ZC4H2 10.2
mut-7 10.2
TFP 9.8
radial spoke protein 3 9.5
contactin-associated protein 2 9.4
BBS8 9.3
skeletal myosin light chain kinase 9.2
PAO-1 9.2
Wah 9.0
putative ATPases 8.8
Hensin 8.7
gravin 8.6
DMAT 8.5
HuB 8.5
alpha myosin heavy chain 8.4
KCNC3 8.3
galactocerebrosidase 8.3
EDL 8.3
SYNGAP1 8.2
D-3-phosphoglycerate dehydrogenase 8.1
voltage gated potassium channel 8.1
DMBT1 8.1
jerky 7.9
A-kinase anchor protein 12 7.8
choline-phosphate cytidylyltransferase 7.8
MLC2 7.8
CRV 7.7
3alpha-HSD 7.7
EVL 7.6
myosin light chain-2 7.6
5-HT-2 7.6
5-HT-1A 7.6
GALC 7.6
AKAP12 7.5
PCM1 7.5
Kv3.3 7.5
MyHC-2b 7.4
voltage-gated potassium channel 7.4
LGI1 7.3
liver glycogen synthase 7.3
secreted frizzled-related protein 1 7.2
KCNMA1 7.2
PRRT2 7.1
SPO 7.0
P41 7.0
PAO 6.9
TTD 6.9
nucleotide-binding protein 6.9
actin-like protein 6.8
myotilin 6.8
Calsequestrin 6.8
GGN 6.8
MHC IIa 6.7
PP7 6.7
ACHE 6.7
Caspr2 6.7
GLD 6.7
O11 6.7
MYOD 6.6
MLC1 6.5
CLCN1 6.5
REC 6.5
ATPase mRNA 6.4
CNTF receptor 6.4
WFS1 6.3
OUT 6.3
MERRF 6.3
SCN4A 6.2
succinic semialdehyde dehydrogenase 6.2
DSP-4 6.2
TPT 6.2
phosphomannomutase 6.2
PKH 6.2
preprodynorphin 6.2
calcium-activated potassium channel 6.1
JMJD2A 6.1
HuC 6.1
more...
Disease
Abomasal rupture 13.9
Miles-Carpenter syndrome 12.3
blepharoclonus 11.8
Glycogen storage disease type 0 11.3
nutmeg liver 11.1
Reading epilepsy 11.0
APSS 10.6
Jacksonian epilepsy 10.3
WM1 10.3
Glottis 10.2
Acute respiratory acidosis 10.1
atonic seizure 10.0
Epilepsia partialis continua 9.7
Sleep attacks 9.7
Renal tubular dysfunction 9.3
BBS8 9.3
Psychogenic polydipsia 9.3
Transient hypertension 9.3
Progressive dementia 9.1
Aspiration pneumonitis 9.0
neuromyotonia 8.9
Molybdenum cofactor deficiency 8.7
Morvan 8.7
CRV 8.6
Lennox syndrome 8.6
Cortical blindness 8.5
Meige 8.4
Water intoxication 8.4
Pel 8.4
REM sleep behavior disorder 8.3
Lederer 8.3
sleep terrors 8.2
Hyperkalemic periodic paralysis 8.2
Twiddler's syndrome 8.1
Opioid Withdrawal 8.0
Diabetic polyneuropathy 8.0
psychomotor epilepsy 8.0
Facial palsy 7.9
early onset schizophrenia 7.8
Cerebellar atrophy 7.8
tetany 7.8
bronchorrhea 7.6
large cell lung cancer 7.6
polioencephalomyelitis 7.6
Diaphragm 7.5
parasomnia 7.5
Nonconvulsive status epilepticus 7.3
olivopontocerebellar atrophy 7.3
Limbic encephalitis 7.3
generalized seizure 7.2
non-gonococcal urethritis (NGU) 7.1
Krabbe disease 7.1
Pseudomonas infection 7.1
parasympathomimetic 7.0
CHARGE association 7.0
Neuromuscular blockade 6.8
anarthria 6.8
Fukuyama congenital muscular dystrophy 6.8
FA2 6.7
Stereotypy 6.6
invasive thymoma 6.6
Neuromuscular blockade 6.6
omphalitis 6.5
reflex epilepsy 6.5
hyperchloremia 6.5
sleepwalking 6.4
Leydig cell hyperplasia 6.4
choreoathetosis 6.3
paramyotonia 6.3
MERRF 6.2
petit mal 6.2
tardive dyskinesia 6.2
tetanus 6.1
BCM 6.1
physical disorders 6.0
behavior disorder 6.0
dyskinesia 6.0
chronic cystitis 6.0
hallucinosis 6.0
Tension 6.0
more...
Symptom
twitching 13.9
Subsultus tendinum 13.9
Facial grimacing 12.3
Myokymia 10.1
muscular incoordination 9.4
Fatigability 9.0
Mouth breathing 8.9
Palatal myoclonus 8.8
dry throat 8.5
carpopedal spasm 8.4
stomach cramps 8.3
clonus 8.3
giddiness 8.3
arm weakness 8.0
GI irritation 8.0
giddiness 7.9
staggering gait 7.8
lumbar back pain 7.5
stuffy nose 7.5
muscle cramps 7.4
tonic seizure 7.2
facial droop 7.0
myoclonus 6.8
retching 6.8
lassitude 6.8
muscle stiffness 6.7
fasciculation 6.6
blepharospasm 6.5
precordial pain 6.5
hyperesthesia 6.5
tonic-clonic seizure 6.4
impaired motor coordination 6.3
asterixis 6.2
labored breathing 6.2
partial seizure 6.1
ACHE 6.1
spasm 6.0
tingling 5.9
athetosis 5.9
excessive sweating 5.8
hypertonia 5.6
otalgia 5.5
incoordination 5.5
muscle rigidity 5.4
eye pain 5.4
fatigue 5.3
tachypnea 5.2
tremor 5.2
tenesmus 5.0
lightheadedness 4.9
dysarthria 4.9
Anoxia 4.8
polydipsia 4.8
breath holding 4.8
weakness 4.8
decreased appetite 4.7
seizures 4.7
ataxia 4.7
cyanosis 4.6
drooling 4.5
lethargy 4.5
spasticity 4.4
hypercapnia 4.4
agitation 4.4
insomnia 4.4
hemiplegia 4.3
torticollis 4.3
consciousness disturbance 4.2
tinnitus 4.2
numbness 4.2
dry eye 4.2
dizziness 4.1
dysesthesia 4.0
paresis 4.0
Stiffness 4.0
vomiting 3.9
blurred vision 3.9
emaciation 3.9
eds 3.9
sleepiness 3.9
more...
Drug
Dopram 10.6
Mivacron 10.5
Haloperidol decanoate 10.3
Minaxolone 10.1
Oxyphenbutazone 9.4
Oxyphenbutazone 9.3
Hypnomidate 9.1
H2SeO3 9.1
Medetomidine 8.3
Pertussis vaccine 8.2
Innovar 8.2
Ceruletide 7.8
Methohexitone 7.7
Valproic Acid 7.4
Sodium thiosulfate 7.3
Doxapram 7.3
Dantrolene sodium 7.1
Cinnarizine 7.1
Lisuride 6.9
Reserpine 6.6
Atipamezole 6.5
Dihydroergotamine 6.4
Camphor 6.3
Camphor 6.3
Cinacalcet 6.2
Ethylenediamine 6.2
Calcium chloride 6.1
Amrinone 6.1
Tubocurarine 6.0
Compound 9 6.0
Levosimendan 5.7
Sodium valproate 5.6
Pilocarpine 5.6
EDR 5.6
Artesunate 5.5
Limonene 5.4
Zonisamide 5.4
Dextrose 5.3
Diclofenac sodium 5.2
DFP 5.1
Clofibrate 4.8
TES 4.8
Metrizamide 4.7
caffeine 4.5
Propofol 4.5
Bupivacaine 4.3
Gabapentin 4.1
Aprotinin 4.1
PFA 3.9
Acyclovir 3.9
EPI 3.9
Clonidine 3.7
RFP 3.7
Ouabain 3.6
DPA 3.6
Fentanyl 3.6
Scopolamine 3.6
FeCl3 3.5
IPM 3.4
MgSO4 3.3
Ginseng 3.2
Atropine 3.2
TTC 3.1
Theophylline 2.9
CaCl2 2.8
DHT 2.8
PTH 2.8
DHT 2.8
Glycerol 2.8
CDP 2.7
CTX 2.5
CTX 2.4
CaCl2 2.3
CaCl2 2.3
ampicillin 2.2
NADH 1.8
Ethanol 1.7
CTX 1.6
ICI 1.5
Histamine 1.5
more...
Enzyme
MsrB 9.9
prepilin peptidase 9.8
galactocerebrosidase 8.0
AiiA 7.9
LipA 7.7
PHB depolymerase 7.1
LasR 6.7
prephenate dehydratase 6.7
pseudouridine synthase 6.6
3alpha-hydroxysteroid dehydrogenase 6.4
triose-phosphate isomerase 6.4
Lod 6.3
phosphocholine cytidylyltransferase 6.2
phosphomannomutase 6.0
succinic semialdehyde dehydrogenase 5.7
hormone-sensitive lipase 5.7
phosphoglycerate dehydrogenase 5.6
tryptophanase 5.5
restriction-modification system 5.5
anthranilate synthase 5.5
aequorin 5.4
pullulanase 5.4
histidine kinase 5.3
elastase 5.2
sulfite oxidase 5.1
chorismate mutase 5.1
sulfite oxidase 5.0
isocitrate lyase 5.0
malate synthase 4.9
carbonyl reductase 4.9
myosin ATPase 4.8
pectate lyase 4.7
3-hydroxyacyl-CoA dehydrogenase 4.5
myosin light chain kinase 4.5
AMP deaminase 4.5
fatty acid desaturase 4.5
polynucleotide phosphorylase 4.4
tryptophan 2,3-dioxygenase 4.2
phosphorylase kinase 4.1
BIS 4.0
diacylglycerol kinase 4.0
SPC 3.6
phosphoglucomutase 3.5
dopamine beta-hydroxylase 3.5
cholinesterase 3.5
ATPase 3.4
deoxyribonuclease 3.4
triphosphatase 3.3
acetylcholinesterase 3.3
pyruvate dehydrogenase 3.2
pyruvate dehydrogenase 3.2
glycerol-3-phosphate dehydrogenase 3.1
glycerol-3-phosphate dehydrogenase 3.1
prolyl hydroxylase 3.1
urease 3.1
urease 3.1
botulinum neurotoxin 3.0
NADPH-diaphorase 3.0
adenylate kinase 3.0
BAL 3.0
succinate dehydrogenase 2.9
chitinase 2.9
malate dehydrogenase 2.8
phosphodiesterase 2.7
carbonic anhydrase 2.6
DNase 2.6
MDP 2.5
adenylate cyclase 2.5
pyruvate dehydrogenase 2.5
diaphorase 2.5
phosphorylase 2.5
isocitrate dehydrogenase 2.3
creatine kinase 2.3
sulfatase 2.3
cellulase 2.2
isocitrate dehydrogenase 2.2
S1 nuclease 2.1
enolase 2.1
phosphofructokinase 2.0
neutrophil elastase 1.9
more...
Compound
2-chloro-6-(1-piperazinyl)pyrazine 12.9
Ethamivan 11.6
3-butenenitrile 11.4
octyl hexanoate 11.3
2-butenenitrile 10.8
Dopram 10.6
Yohimbine hydrochloride 10.1
Guanidinoethane sulfonic acid 9.8
Dihydrotachysterol 9.7
DPTH 9.7
U 50488 9.7
SQ 20009 9.5
Bemegride 9.4
TPTA 8.9
Pyrantel 8.8
Trimethadione 8.7
ST-37 8.7
Diphenyl diselenide 8.6
Iproniazid 8.5
1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline 8.5
1-(3-chlorophenyl)piperazine 8.4
Nitrofen 8.0
L-cysteine sulfinic acid 8.0
Relax 7.9
PAPP 7.8
octyl acetate 7.8
4-hydroxy-3-methoxybenzaldehyde 7.8
4-hydroxy-3-methoxybenzaldehyde 7.8
TFF 7.7
Methomyl 7.7
Zingerone 7.7
PAPP 7.6
Mivacurium 7.6
IDPN 7.6
3,4-DAP 7.4
Dantrolene sodium 7.4
Hydroxocobalamin 7.4
cycloheptane 7.3
Dihydroergotamine 7.3
4-hydroxy-3-methoxybenzaldehyde 7.3
S-sulfocysteine 7.2
Pancuronium 7.2
Edrophonium 7.1
ACPC 7.1
Betaxolol 7.1
Tetrabenazine 7.1
Phosphoserine 7.0
cyclooctane 7.0
Picrotoxin 7.0
Picrotoxin 7.0
Dimethoate 6.8
Cromakalim 6.8
Droperidol 6.7
MCPP 6.7
Succinylcholine 6.6
IEA 6.5
OMPA 6.4
homoserine 6.4
homoserine 6.4
homoserine 6.4
Atracurium 6.4
Ondansetron 6.4
Dantrolene 6.3
Zonisamide 6.3
Riluzole 6.3
Lincomycin 6.2
Rivastigmine 6.2
Camphor 6.2
Lincomycin 6.2
Farnesol 6.2
Foscarnet 6.1
Tubocurarine 6.1
DTP 6.1
Hexamethonium 6.1
BCM 6.1
cyclohexanecarboxamide 6.0
Ropivacaine 6.0
Leucovorin 6.0
Soman 6.0
Methoxamine 6.0
more...