Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0231528 (myalgia)
 6,565 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Adult onset Still's disease is a disorder characterized by spiking fevers, rash, arthritis, serositis and myalgia. Erosive arthritis is a well recognized feature, however, myositis is not. We describe a patient with adult onset Still's disease, polymyositis (PM) and rhabdomyolysis successfully treated with methotrexate (MTX) and corticosteroids. This occurrence has previously been reported, however without the presence of rhabdomyolysis or treatment with MTX. Suppression of disease activity was followed by marked radiographic improvement of the arthritis. MTX and corticosteroids in combination may be indicated for the treatment of adult onset Still's disease when PM and erosive arthritis occur.
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PMID:Coexistence of adult onset Still's disease and polymyositis with rhabdomyolysis successfully treated with methotrexate and corticosteroids. 266 59

A 71 year-old man with adult onset Still's disease was admitted to our hospital because of fever, sore throat, myalgia and macular nonpruritic salmon pink eruption. He was treated with prednisolone, 40 mg daily and these symptoms disappeared. When the dose of prednisolone was reduced to 30 mg daily, he began to notice fever. 5 days later he developed adult respiratory distress syndrome (ARDS). The dose of prednisolone was increased to 50 mg daily and oxygen administration was started. All symptoms began to improve immediately and the dose of prednisolone was decreased to 40 mg daily. 10 days later he noticed fever and skin rash. Laboratory investigation showed platelet counts of 69,000/mm3, a ferritin of 37,000 ng/ml, and increased fibrinogen degradation product, indicating increased activity of adult onset Still's disease associated with disseminated intravascular coagulation (DIC). The dose of prednisolone was again increased to 60 mg daily, and 100 mg of nafamostat mesilate was administrated intravenously. All above symptoms associated with adult onset Still's disease and DIC disappeared. The dose of prednisolone was gradually decreased and the clinical course was uneventful with daily administration of 10 mg of prednisolone. Although there are a couple of case report which described the association of adult onset Still's disease with either ARDS or DIC, the association of adult onset Still's disease with both ARDS and DIC have not been reported yet.
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PMID:[A case of adult onset Still's disease complicated with adult respiratory distress syndrome and disseminated intravascular coagulation]. 755 55

The 17-year-old was admitted for investigation of a fever persisting for three weeks in spite of antibiotic treatment. Based on the clinical picture presenting with fugitive exanthema during febrile episodes, myalgia, polyserositis, leucocytosis with toxic granulations and-- after an antibiotic window--negative cultures of all investigated fluids (blood, pleural and peritoneal fluid), adult-type Still's disease was diagnosed. Treatment with steroids and indomethacine was only temporarily successful. Therapeutic stabilization first occurred under administration of phenylbutazone. The course was complicated by three surgical abdominal interventions because of an unclear acute abdomen, a strangulation ileus and a small-bowel perforation.
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PMID:[A 17-year-old female patient with recurring fever, chills, exanthema, myalgia and polyserositis]. 864 95

This retrospective descriptive study aims to characterise and compare the clinical manifestations, course and outcome of 16 Oriental patients with adult-onset Still's disease diagnosed in the last 4 years with published data based on Western populations and another Oriental (Japanese) series. Like the Japanese, we found a female preponderance, an older age at onset, and fewer patients with abdominal pain, myalgia, sore throat and serositis compared to the Western series. A longer delay in diagnosis occurred in patients lacking either arthritis or rash at presentation. Most patients had mild hyponatraemia and 2 patients had overt syndrome of inappropriate anti-diuretic hormone secretion. All patients showed a dissociation of elevated aldolase with normal to low creatine kinase levels. Over 50% relapsed within a year from diagnosis and needed slow-acting anti-rheumatic drugs as steroid-sparing agents. Two were given intravenous pulse cyclophosphamide therapy for progressive pneumonitis. Outcome was generally good with minimal functional impairment and no mortality.
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PMID:Adult-onset Still's disease in an oriental population: manifestations, course and outcome in 16 patients. 958 68

We describe a 21-year old man who was diagnosed as having adult onset Still's disease (AOSD) in association with isotretinoin treatment for acne conglobata. The patient was febrile, with a macular salmon pink rash, arthritis, hepatosplenomegaly, and axial lymphadenopathy. Laboratory results showed leukocytosis, mild liver dysfunction and negative rheumatoid factor and antinuclear antibodies. Isotretinoin, an orally active derivative of vitamin A, has been associated with various rheumatologic conditions such as arthralgia, myalgia, vasculitis and arthritis. The etiology of rheumatic disorders associated with retinoids is still obscure; however, it is presumed that immunomodulation by several mechanisms (such as an alteration of the cytokine balance) is probably ascribable to this interesting association.
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PMID:Isotretinoin-induced adult onset Still's disease. 1107 5

We report the case of a woman with a characteristic transient skin rash, fever, severe polyarthritis, hepatosplenomegaly, lymphadenopathy and myalgia. The clinical and laboratory data led to a diagnosis of adult-onset Still's disease. The elevated levels of serum ferritin and caeruloplasmin could be important as diagnostic indicators.
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PMID:Elevated serum caeruloplasmin level in a patient with adult Still's disease. 1195 55

A 29-year old women with adult onset Still's disease (AOSD) was presented. On addmision to hospital the patient was febrile, with sore throat, arthralgia/arthritis and myalgia. The patient had lymphadenopathy on the neck, and laboratory findings showed leukocytosis with neutrophilia, accelarated erythrocyte sedimation rate (ESR), increased reactants of acute inflammation and normocytic anemia. During the diagnostic process, infectious, hematologic and neoplastic diseases were ruled out and the diagnosis of AOSD was made. The therapy with metilprednisolone 1 mg/kg of body weight was started. One month latter, the clinical status of the patient improved as well as laboratory findings. The dose of steroids was tappered to 16 mg per day. After 6 months of therapy, steroids were stopped and patient was followed further one year and she was free of symptoms of disease.
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PMID:[Still's disease in adulthood--case report of a female patient and review of the literature]. 1247 51

In this study we aimed to investigate the findings in patients with adult-onset Still's disease (AOSD) admitted with fever of unknown origin (FUO) during the last 18 years in our unit, in order to discover the ratio of such patients to all patients with FUO during the same period, and to determine the clinical features of AOSD in FUO. The number and the aetiologies of the patients with FUO diagnosed between 1984 and 2001, and the clinical features of those with AOSD, were taken from the patient files. The diagnosis of AOSD was reanalysed according to the diagnostic criteria of Cush et al. [11]. The presumed diagnoses before a diagnosis of AOSD was established were also noted. The chi(2) and Fisher's exact tests were used for statistical analysis. We studied 130 patients with a diagnosis of FUO, 36 (28%) of whom had collagen vascular diseases. Of these 36 patients, 20 (56%, 12 female, 8 male, mean age 34 years, range 16-65) had AOSD. Clinical and laboratory findings were as follows: fever (100%), arthralgia (90%), rash (85%), sore throat (75%), arthritis (65%), myalgia (60%), splenomegaly (40%), hepatomegaly (25%), lymphadenopathy (15%), anaemia (65%), neutrophilic leukocytosis (90%), increased erythrocyte sedimentation rate (100%), elevated transaminase levels (65%), a negative RF (100%), and a negative FANA (80%). Antibiotics had been prescribed in 18 (90%) of cases. The presumed infectious diagnoses were streptococcal tonsillitis/pharyngitis (50%), infective endocarditis (four patients), sepsis (two patients) and acute bacterial meningitis (two patients). The presumed non-infectious diagnoses were acute rheumatic fever (three patients), seronegative rheumatoid arthritis (two patients) and polymyositis (two patients). Sixteen patients were followed for a mean duration of 30 months (range 2-59). A remission was obtained with indomethacin in three cases (19%), and with prednisolone in the remainder. Relapse was detected in three cases (19%). AOSD is one of the most frequent aetiologies of FUO. During the diagnostic course of a patient with FUO, a maculopapular rash and/or arthralgia and/or sore throat should raise the suspicion of AOSD. Because the disease has heterogeneous clinical findings, certain bacterial infections (e.g. streptococcal pharyngitis and sepsis) are generally considered and the prescribing of antibiotics is common.
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PMID:Fever of unknown origin: a review of 20 patients with adult-onset Still's disease. 1274 Jun 70

Adult-onset Still's disease is a multisystem inflammatory disorder of unknown etiology and is characterized by high, spiking fever, arthritis, evanescent maculopapular rash, myalgia, serositis, leukocytosis, and involvement of various organs including the eyes. The ocular manifestations have been described including orbital pseudotumor, ptosis, and diplopia with orbital pain but never Purtscher's-like retinopathy. We describe a 21-year-old male patient with adult-onset Still's disease who developed the Purtscher's-like retinopathy. To our knowledge, this is the first reported adult-onset Still's disease patient with Purtscher's-like retinopathy as the initial presentation.
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PMID:Purtscher's-like retinopathy as an initial presentation of adult-onset Still's disease: a case report and review of the literature. 1690 Mar 1

The clinical features of adult onset Still's disease (AOSD) have rarely been described in Thai patients. We report the clinical manifestations, laboratory findings, and outcome of 16 Thai patients with AOSD, and compare these findings with those of the western and other oriental series. Fourteen patients (87.5%) had the onset of their disease between 16-35 years of age. The most common features presented were fever (100%), arthralgia and myalgia (100%), significant weight loss (84.6%), arthritis (81.3%), skin rashes (68.8%), sore throat (62.5%), elevated erythrocyte sedimentation rate (100%), leukocytosis (93.8%), and liver dysfunction (75%). Pleuro-pericarditis and abdominal pain were uncommon. All but 2 patients required corticosteroids to control their systemic disease activity. The clinical course of 13 patients, who were followed for more than 12 months, was monocyclic systemic disease in four cases, polycyclic systemic disease in five, chronic articular monocyclic systemic in one, and chronic articular polycyclic systemic in three. When compared with western and other oriental series, the AOSD in Thai patients shared similar clinical features and laboratory findings, suggesting that mechanisms of pathogenesis may be similar in patients from widely different genetic backgrounds and geographic locations. Corticosteroids were frequently required and dramatically effective.
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PMID:Adult onset Still's disease: clinical features and outcome in 16 Thai patients. 1703 60


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