Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0221002 (primary hyperparathyroidism)
4,921 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
parathyroid hormone 1388
PTH 611
Sep 313
parathormone 271
alkaline phosphatase 206
calcitonin 139
chronic renal failure 131
She 121
HPT 90
osteocalcin 82
calcium-sensing receptor 79
MEN1 75
Parathyroid hormone 74
AMP 71
insulin 70
parathyroid hormone-related protein 68
albumin 63
MRI 60
parafibromin 55
RET 53
gastrin 48
thymus 44
CDC73 41
collagen 39
Pol 36
renin 34
Mol 34
FHH 33
menin 30
type I collagen 29
CaSR 27
calcium sensing receptor 27
cyclin D1 26
BMD 26
MEN2A 25
CDKN1B 22
reserved 22
RET proto-oncogene 22
GFR 21
prolactin 21
vitamin D receptor 20
glucagon 20
secretin 20
Calcitonin 18
growth hormone 17
serum albumin 16
p27(KIP1) 16
Osteocalcin 16
somatostatin 16
BGP 16
ZES 13
chromogranin A 13
ALP 13
Mal 12
thyroid hormone 12
AP17 11
acid phosphatase 11
pancreatic polypeptide 11
p53 11
proto-oncogene 10
neurofibromatosis 10
type I procollagen 10
tumour suppressor 10
JAMA 9
CCND1 9
ACTH 9
nodal 9
sclerostin 9
catenin 9
glycoprotein 9
guanine nucleotide binding protein 9
PTH/PTHrP 9
FDG 9
tartrate-resistant acid phosphatase 9
gut 8
CO2 8
Alkaline phosphatase 8
cytokine 8
p27 8
GCMB 8
more...
Disease
primary hyperparathyroidism 4921
hypercalcemia 1638
adenoma 1457
hyperparathyroidism 1412
tumor 575
cancer 456
carcinoma 416
multiple endocrine neoplasia 353
osteoporosis 298
hypoparathyroidism 216
bone disease 200
Parathyroid 196
nephrolithiasis 194
hypertension 192
hypercalciuria 172
Parathyroid carcinoma 157
chronic renal failure 141
parathyroid hyperplasia 122
MEN1 122
diabetes 114
metastases 113
renal failure 111
medullary thyroid carcinoma 104
vitamin D deficiency 104
osteitis 98
hyperthyroidism 93
pheochromocytoma 87
PDB 82
osteomalacia 80
urolithiasis 78
endocrine disorder 78
pancreatitis 74
renal disease 73
multiple myeloma 67
nephrocalcinosis 67
depression 58
acute pancreatitis 53
goiter 52
renal insufficiency 51
sarcoidosis 51
hypercalcemia of malignancy 45
Best 44
peptic ulcer 43
HRPT2 42
MEN 2 40
cardiovascular disease 39
thyroid cancer 38
acromegaly 37
tumorigenesis 37
bone metastases 37
uremia 37
breast cancer 35
thyroid nodule 35
Parathyroid adenoma 33
thyrotoxicosis 33
renal osteodystrophy 33
pseudohypoparathyroidism 31
hypothyroidism 30
renal tubular acidosis 30
Brown 30
Brown tumor 30
tetany 28
SEM 28
rare disease 27
BMD 26
renal impairment 26
dehydration 26
rickets 25
Cushing's syndrome 24
lymphoma 24
Zollinger-Ellison syndrome 24
gastrinoma 24
anemia 24
Familial hypocalciuric hypercalcemia 22
pathological fracture 22
insulinoma 22
carcinoid 21
malabsorption 21
aldosteronism 21
multinodular goiter 21
more...
Symptom
weakness 101
fatigue 77
pain 75
anesthesia 75
bone pain 52
polyuria 51
nausea 45
vomiting 40
constipation 37
abdominal pain 35
anorexia 31
polydipsia 30
lethargy 26
arthralgia 17
diarrhea 16
nausea and vomiting 14
headache 13
Ill 13
back pain 13
renal colic 12
seizures 11
asthenia 10
dyspnea 9
discomfort 9
discomfort 9
myalgia 9
respiratory distress 9
hypotonia 9
memory loss 8
epigastric pain 8
hoarseness 7
knee pain 6
thinning 6
paresthesia 5
low back pain 5
hepatosplenomegaly 5
acute abdomen 4
hunger 4
ENT 4
neck pain 4
colic 4
chest pain 4
agitation 4
hip pain 4
cough 3
angina 3
dizziness 3
hyperemesis 3
sleepiness 3
heartburn 3
exhaustion 3
Psychiatric symptoms 3
flank pain 3
apathy 3
Gastrointestinal symptoms 3
Stiffness 2
cyanosis 2
numbness 2
dysarthria 2
consciousness disturbance 2
dysuria 2
hyperemesis gravidarum 2
leg pain 2
sore throat 2
ataxia 2
analgesia 2
tingling 2
phosphatemia 2
shortness of breath 2
paraparesis 2
splenomegaly 2
pallor 2
chronic constipation 1
lassitude 1
paresis 1
stridor 1
clubbing 1
syncope 1
lump in the neck 1
trigeminy 1
more...
Drug
PTH 621
Cinacalcet 45
Nephron 10
APD 10
Cardiovasc 10
Gel 9
Dial 9
CTX 7
Nephron 7
CTX 7
ENT 7
CTX 7
Dermatol 7
CaCl2 6
MRC 6
CaCl2 6
CaCl2 6
Denosumab 5
MTC 5
Cimetidine 5
Cimetidine 5
Cinacalcet hydrochloride 4
EHDP 4
ROC 4
Albumin 4
lysine 4
Angiotensin II 3
Aredia 3
Leaf 3
Estrogens 3
DPA 2
Ipriflavone 2
Monit 2
Histamine 2
Zoledronic acid 2
Raloxifene 2
Clodronate 2
Spectrum 2
Dakar 2
Teriparatide 2
Methylene blue 2
Indocyanine green 2
Gallium nitrate 2
TAT 2
Growth hormone 2
Growth hormone 2
IL-11 2
Calcifediol 1
Portal 1
TAC 1
Bonefos 1
ALA 1
Sandostatin 1
Rocaltrol 1
Hypaque 1
Fraction 1
CSF 1
G-CSF 1
PTC 1
nitroglycerin 1
PCB 1
Prednisone 1
Indomethacin 1
DDAVP 1
Serum albumin 1
Ammonium chloride 1
Chloramine T 1
CAM 1
Fluorescein 1
Ketoconazole 1
Sandostatin 1
Meditec 1
DM1 1
Calcium gluconate 1
DDAVP 1
Hypaque 1
ADM 1
Fluorescein 1
Zoledronic acid 1
HCG 1
more...
Enzyme
alkaline phosphatase 206
ERK 60
renin 34
acid phosphatase 11
protein kinase 10
adenylate cyclase 8
MDP 7
APC 5
ATPase 5
MIP 5
protein kinase C 4
peroxidase 3
P-glycoprotein 3
PRA 3
TAT 2
ACS 2
succinate dehydrogenase 2
glucose-6-phosphate dehydrogenase 2
focal adhesion kinase 2
thyroid peroxidase 2
lysozyme 2
lipase 2
tyrosine hydroxylase 2
dihydropyrimidine dehydrogenase 2
catalase 2
ACE 2
collagenase 2
proline iminopeptidase 2
cathepsin K 2
mitogen-activated protein kinase 2
creatine kinase 2
PHT 2
calcium pump 2
DNA methyltransferase 1
CYP3A4 1
cholinesterase 1
NO synthase 1
RNase 1
AMP-activated protein kinase 1
transcriptase 1
luciferase 1
NQO1 1
urease 1
ascorbate oxidase 1
phosphodiesterase 1
glyceraldehyde-3-phosphate dehydrogenase 1
RNA polymerase 1
phosphofructokinase 1
1-hydroxylase 1
asparaginase 1
guanylate cyclase 1
isoamylase 1
TGT 1
AMPK 1
aspartate aminotransferase 1
neuraminidase 1
PDE 1
alpha-glucosidase 1
cytochrome oxidase 1
caspase-3 1
endonuclease 1
acetylcholinesterase 1
diaphorase 1
gamma-glutamyl transpeptidase 1
E-2 1
ribonuclease 1
prostaglandin synthetase 1
alanine aminotransferase 1
MEK 1
urease 1
ribonuclease 1
phosphorylase kinase 1
phospholipase C 1
CPT 1
RNase 1
homogentisate 1,2-dioxygenase 1
DNA polymerase 1
trypsin 1
hormone-sensitive lipase 1
prostate-specific antigen 1
more...
Compound
calcium 2092
Clin 792
Dec 374
vitamin D 310
phosphate 296
creatinine 210
phosphorus 176
HPT 90
cAMP 77
DNA 74
AMP 71
sodium 58
glucose 57
oxalate 42
Vitamin D 40
water 37
aldosterone 36
His 33
potassium 29
carbonate 28
Thyroid 28
EDTA 27
BMD 26
25-dihydroxycholecalciferol 25
EDTA 25
urea 23
iodine 22
ethanol 19
Calcitonin 18
salt 17
Estrogen 14
arginine 14
ALP 13
Estrogen 13
nitrogen 12
TSH 11
methionine 11
CO2 10
Insulin 10
ACTH 9
phosphoric acid 9
Dial 9
POP 8
Lithium 8
Mg2+ 8
25-hydroxycholecalciferol 8
tyrosine 7
CTX 7
Alendronate 7
HCl 7
Alendronate 7
Cardiol 6
TRH 6
leucine 6
CaCl2 6
lysine 6
MTC 5
ammonium 5
6-12 5
tryptophan 5
NH2 4
barium 4
Adrenal 4
Octreotide 4
nitric oxide 4
Angiotensin II 4
noradrenaline 4
EHDP 4
iron 4
cGMP 4
oxygen 4
proline 4
Propranolol 3
GAL 3
strontium 3
nitrate 3
Uric acid 3
TAR 3
Propranolol 3
DBP 3
more...