Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0221002 (primary hyperparathyroidism)
 4,921 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
SPCS2 11.7
SEC11C 11.7
CDC73 11.2
RANGRF 11.1
beta3Gal-T2 11.1
parafibromin 11.0
AP17 10.9
GCMB 10.6
Wermer syndrome 10.5
HPT 10.1
EXOC8 10.1
parathormone 9.9
CACYBP 9.9
PTHRP 9.8
FHH 9.7
MEN1 9.7
nitric oxide synthase 2A 9.7
PTHR2 9.5
calcium sensing receptor 9.3
TROVE2 9.2
PTH 9.2
parathyroid hormone 9.1
SEC61G 9.1
KIF1Bbeta 9.1
microsomal signal peptidase 9.1
Parafibromin 9.1
MEN2A 9.0
KCNJ16 9.0
ZES 8.9
cyclin-dependent kinase inhibitor p27kip1 8.9
calcium-sensing receptor 8.7
PRUNE2 8.7
menin 8.6
GPR64 8.6
Cartilage acidic protein 1 8.6
CDKN1B 8.5
RPL23 8.4
TET2 protein 8.3
CaSR 8.3
Parathyroid hormone 8.3
THRAP3 8.2
MOG1 8.2
CCND1 protein 8.1
parathyroid hormone-like peptide 8.1
ILBP 8.1
SP-I 8.0
p27(KIP1) 8.0
ASXL3 8.0
regulator of G-protein signaling 5 7.9
OAF 7.9
RPS25 7.9
BONE 7.9
RPN1 7.9
RET proto-oncogene 7.8
FMTC 7.7
BGP 7.7
RPL26 7.5
extracellular calcium-sensing receptor 7.5
parathyroid hormone-related protein 7.4
HPT1 7.3
claudin-19 7.3
HPTP 7.1
HHM 7.1
HIC1 7.1
ALX1 7.1
Menin 7.0
SLC12A1 7.0
PAX1 6.9
SLC34A1 6.9
GCM1 6.8
UCHL5 6.8
RET 6.7
PHP 6.6
PTH1 6.6
CDKN2C 6.6
TMEM127 6.6
glutaredoxin 2 6.5
Melanoma inhibitory activity 6.5
PTH1R 6.4
cyclin-dependent kinase inhibitor 1B 6.4
PTH/PTHrP 6.4
guanine nucleotide binding protein 6.4
RIZ1 6.4
TNXB 6.4
renal) 6.4
TPX 6.2
RET protein 6.2
Osteocalcin 6.2
PFK-1 6.1
Claudin-16 6.1
PolB 6.0
PRKAG2 6.0
NPS 6.0
MTC 6.0
CgA 6.0
chronic renal failure 6.0
PRKAR1A 6.0
3B3 5.9
TSL 5.9
ret proto-oncogene 5.9
SGD 5.8
ret 5.8
HUMAN 5.7
calcitonin 5.7
BMD 5.7
VIT 5.6
Calcitonin 5.6
type I procollagen 5.6
FGF23 5.6
osteocalcin 5.6
sclerostin 5.6
KCNJ5 5.6
CYP24A1 5.5
SFRP1 5.5
HLA B 5.4
multidrug resistance-related protein 5.4
PYGM 5.4
dentin matrix protein 1 5.4
TB10 5.4
synaptotagmin 1 5.3
vitamin D-binding protein 5.3
ZFX 5.3
CCND1 5.2
HCE 5.1
Transforming growth factor-alpha 5.1
Oestrogen receptor 5.0
GFR 5.0
AIP 5.0
gastrin 5.0
Klotho 5.0
klotho 5.0
TBX1 5.0
TGC 4.9
SDHB 4.9
VDR mRNA 4.9
TTF1 4.9
ENPP1 4.9
mGluR8 4.8
BEN 4.8
LRP5 4.8
chromogranin A 4.8
alkaline phosphatase 4.8
dysbindin 4.8
histamine H2 receptor 4.8
VDR 4.8
RAD54 4.8
BMPR1A 4.8
BRI 4.8
ARD 4.7
vitamin D receptor 4.7
secretin 4.7
GLA 4.7
IL-17RA 4.7
DBM 4.6
AXIN2 4.6
AMG 4.6
Adenylyl cyclase 4.6
DMR 4.6
SYN 4.6
RSS 4.6
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Disease
primary hyperparathyroidism 12.7
Endocrine myopathy 12.7
localized parathyroid carcinoma 12.7
Hypercalcemic nephropathy 12.7
arthritis of the lumbar spine 12.7
Ectopic parathormone production 12.7
Neonatal hyperparathyroidism 11.9
Familial hyperparathyroidism 11.9
Parathyroid adenoma 11.8
parathyroid neoplasm 11.8
parathyroid chief cell adenoma 11.7
recurrent parathyroid carcinoma 11.7
Parathyroid carcinoma 11.5
FIHP 11.4
metastatic parathyroid carcinoma 11.2
HRPT2 11.2
Hungry bone syndrome 11.2
hypercalcaemia due to parathyroid adenoma 11.1
Struma nodosa 11.1
Brown tumor of hyperparathyroidism 11.1
Familial hypocalciuric hypercalcemia 11.1
Brown tumor 11.0
FBH1 10.8
Secondary carcinoma 10.7
parathyroid hyperplasia 10.5
Parathyroid 10.5
Neonatal hypocalcemia 10.4
Parathyromatosis 10.4
Hypocalcemic tetany 10.3
Slipped capital femoral epiphyses 10.3
Multiple renal cysts 10.1
hypercalcemia 10.0
hyperparathyroidism 10.0
Parathyroid gland 9.9
Parathyroid gland 9.9
Parathyroid gland 9.9
NHPT 9.9
MEN1 9.7
Proximal myopathy 9.7
Transient hypoparathyroidism 9.7
TKC 9.7
disorders of calcium metabolism 9.6
Ectopic parathyroid adenoma 9.5
Adenolipoma 9.5
hypercalcemia of malignancy 9.4
Islet cell tumor 9.3
JPD 9.3
Medullary nephrocalcinosis 9.2
Uremic encephalopathy 9.2
Tertiary hyperparathyroidism 9.1
sponge kidney 9.1
benign giant cell tumor of bone 9.1
hypoparathyroidism 9.0
multiple endocrine neoplasia 9.0
nephrolithiasis 8.9
Hepatic osteodystrophy 8.9
hypercalciuria 8.8
adenoma 8.8
Idiopathic hypercalciuria 8.7
Primary osteoporosis 8.6
endocrine disorder 8.6
Idiopathic osteoporosis 8.6
Burnett 8.6
MEN 2 8.5
Dialysis dementia 8.5
Proximal renal tubular acidosis 8.5
Papillary Thyroid Carcinoma 8.5
Hypocalciuria 8.5
osteitis 8.4
Enteric hyperoxaluria 8.3
Pulmonary calcification 8.3
Milwaukee shoulder 8.3
nephrocalcinosis 8.2
Milwaukee shoulder 8.2
pituitary hyperfunction 8.1
Medullary Thyroid Carcinoma 8.1
Adynamic bone disease 8.1
Peripheral giant cell granuloma 8.1
Renal tubular dysfunction 8.1
thyroid adenoma 8.1
G cell hyperplasia 8.0
pseudogout 7.9
tetany 7.9
cafe au lait spots 7.9
Calciphylaxis 7.8
pseudohypoparathyroidism 7.8
ganglioneuromatosis 7.7
thymic neoplasm 7.7
MEN 2B 7.6
gastrinoma 7.6
Secondary hyperparathyroidism 7.6
medullary thyroid carcinoma 7.6
chondrocalcinosis 7.6
Malignant pheochromocytoma 7.5
multinodular goiter 7.5
bone disease 7.4
Distal renal tubular acidosis 7.4
Papillary adenocarcinoma 7.4
osteomalacia 7.4
demineralization of bone 7.3
renal osteodystrophy 7.3
hypophosphaturia 7.3
Adenoma 7.3
Adenoma 7.3
pancreatic gastrinoma 7.3
thyroid nodule 7.3
Azotemia 7.2
fibroblastic osteosarcoma 7.2
cystinuria 7.1
hyperoxaluria 7.1
Zollinger-Ellison syndrome 7.0
urolithiasis 7.0
pseudopseudohypoparathyroidism 7.0
Aortic valve calcification 7.0
osteodystrophy 6.9
IRMA 6.9
vitamin D deficiency 6.9
thyroid mass 6.9
endocrine neoplasm 6.9
Oncocytoma 6.8
hyperchloremia 6.8
Metabolic bone disease 6.7
hypervitaminosis 6.7
hypermagnesemia 6.7
tachycardia-bradycardia syndrome 6.7
PHP 6.6
prolactinoma 6.6
Vernet 6.6
renal tubular acidosis 6.6
familial periodic paralysis 6.6
OHD 6.6
Recklinghausen 6.5
Bone marrow edema 6.5
islet cell carcinoma 6.5
depressive psychosis 6.5
Bone fragility 6.5
Oropharyngeal dysphagia 6.5
Tauri 6.4
pathological fracture 6.4
MTC 6.4
PDB 6.3
capsulitis 6.3
acute arthritis 6.3
aminoaciduria 6.3
scleredema 6.3
metastatic pheochromocytoma 6.2
Hyperplasia 6.2
Central giant cell granuloma 6.2
Vocal cord paralysis 6.1
Jaccoud 6.1
Hajdu-Cheney syndrome 6.1
spindle cell thymoma 6.0
glucagonoma 6.0
Giant cell tumor of bone 6.0
thyroid disorder 6.0
Cardiovascular morbidity 6.0
myxedema 5.9
Malignant disease 5.9
thyrotoxicosis 5.9
Ossifying fibroma 5.9
more...
Symptom
Postoperative vomiting 7.8
lump in the neck 7.0
phosphatemia 6.9
polyuria 6.8
bone pain 6.8
painful swallowing 6.6
renal pain 6.6
renal colic 6.6
polydipsia 6.5
Lhermitte's sign 6.3
trigeminy 6.1
hyperemesis 6.0
Psychiatric symptoms 5.9
jaw pain 5.1
Gastrointestinal symptoms 5.1
generalized pain 5.0
lethargy 4.9
physical symptom 4.7
aphonia 4.7
asthenia 4.6
hyperemesis gravidarum 4.6
constipation 4.5
lassitude 4.5
loin pain 4.3
Physical findings 4.3
weakness 4.1
consciousness disturbance 4.0
hoarseness 3.9
arthralgia 3.9
epigastric pain 3.9
anorexia 3.9
hip pain 3.8
memory loss 3.8
knee pain 3.8
Stiffness 3.7
stomach pain 3.7
nausea 3.6
ankle pain 3.6
ketonuria 3.5
tingling 3.3
atypical chest pain 3.3
hypotonia 3.3
thigh pain 3.3
fatigue 3.3
nausea and vomiting 3.2
heartburn 3.2
myalgia 3.1
flank pain 3.1
acute abdomen 3.1
colic 3.0
vomiting 3.0
Ill 2.9
hepatosplenomegaly 2.9
abdominal pain 2.9
clubbing 2.9
muscle cramps 2.8
back pain 2.8
neck pain 2.7
paresthesia 2.7
leg pain 2.7
emaciation 2.6
catatonia 2.5
abnormal gait 2.5
decreased appetite 2.5
dysuria 2.4
pallor 2.4
chronic constipation 2.3
fasciculation 2.3
tonic-clonic seizure 2.3
ENT 2.3
apathy 2.2
paraparesis 2.2
sore throat 2.2
hunger 2.2
anesthesia 2.1
sciatica 2.1
abdominal discomfort 1.9
oliguria 1.8
thinning 1.8
cyanosis 1.8
dysarthria 1.8
low back pain 1.7
twitching 1.7
fever of unknown origin 1.6
respiratory distress 1.6
stridor 1.5
discomfort 1.4
masculinization 1.3
numbness 1.3
shortness of breath 1.3
Wind 1.3
discomfort 1.3
shoulder pain 1.2
agitation 1.1
dyspnea 1.1
dizziness 1.0
ophthalmoplegia 1.0
pain 0.9
diarrhea 0.8
acute pain 0.7
sleepiness 0.6
chest pain 0.6
headache 0.6
exhaustion 0.5
splenomegaly 0.4
cachexia 0.2
hepatomegaly 0.2
paresis 0.2
angina -0.1
vertigo -0.1
seizures -0.2
ataxia -0.3
cough -0.3
syncope -0.5
functional recovery -1.1
analgesia -1.1
acidity -1.2
tremor -1.5
overweight -2.0
collapse -2.1
Drug
Cinacalcet 10.5
Cinacalcet hydrochloride 9.7
PTH 9.2
Calcifediol 8.9
Aredia 8.6
Bonefos 8.6
Gallium nitrate 7.4
Rocaltrol 7.2
Calcium gluconate 7.1
Chloramine T 6.8
Ipriflavone 6.7
APD 6.2
MTC 6.0
Denosumab 5.9
EHDP 5.7
Clodronate 5.7
Meditec 5.5
Teriparatide 5.3
Ammonium chloride 4.8
Indocyanine green 4.5
Sandostatin 4.4
Sandostatin 4.4
Cimetidine 4.3
Cimetidine 4.3
Raloxifene 4.2
Zoledronic acid 4.0
MEA 3.9
Thyroglobulin 3.7
Zoledronic acid 3.7
IL-11 3.5
MRC 3.5
DPA 3.3
Methylene blue 3.3
DMSA 3.1
Estrogens 3.1
CTX 3.0
CTX 3.0
DDAVP 2.8
DDAVP 2.7
Prednisone 2.7
Ketoconazole 2.6
CaCl2 2.6
CaCl2 2.6
Dakar 2.6
CaCl2 2.6
Hypaque 2.5
TAT 2.4
Albumin 2.4
ENT 2.4
Hypaque 2.4
Serum albumin 2.4
CTX 2.2
Growth hormone 2.1
Sorafenib 2.1
Growth hormone 2.1
DM1 2.0
TAC 2.0
Gel 2.0
Angiotensin II 1.9
Diurnal 1.9
Nephron 1.9
PTC 1.9
Nephron 1.9
ROC 1.7
Fraction 1.3
HCG 1.3
Fluorescein 1.3
ETA 1.2
Histamine 1.2
ALA 1.2
ADM 1.0
Dial 0.9
Fluorescein 0.8
Spectrum 0.7
Portal 0.6
PCB 0.6
G-CSF 0.3
CAM 0.1
Indomethacin 0.0
Leaf -0.2
nitroglycerin -0.5
Ethanol -0.6
lysine -1.2
Monit -1.4
Cardiovasc -1.6
CSF -2.3
Dermatol -2.5
Enzyme
proline iminopeptidase 6.7
PHT 5.7
homogentisate 1,2-dioxygenase 5.1
alkaline phosphatase 4.8
MDP 4.1
calcium pump 3.7
TGT 3.7
PRA 3.5
1-hydroxylase 3.5
dihydropyrimidine dehydrogenase 3.4
E-2 3.2
isoamylase 3.1
ascorbate oxidase 3.1
phosphorylase kinase 2.9
cathepsin K 2.8
MIP 2.7
renin 2.6
acid phosphatase 2.5
TAT 2.4
thyroid peroxidase 2.1
ERK 2.0
prostaglandin synthetase 1.8
hormone-sensitive lipase 1.6
phosphoglycerate kinase 1.6
adenylate cyclase 1.4
asparaginase 1.3
diaphorase 1.2
APC 1.0
PDE 0.8
phosphofructokinase 0.8
glucose-6-phosphate dehydrogenase 0.7
NADPH-diaphorase 0.7
succinate dehydrogenase 0.7
alpha-glucosidase 0.6
P-glycoprotein 0.5
CPT 0.5
DNA methyltransferase 0.4
diaphorase 0.1
kallikrein 0.1
NQO1 0.1
CYP3A4 0.0
glyceraldehyde-3-phosphate dehydrogenase -0.0
ribonuclease -0.0
ribonuclease -0.0
GSK -0.1
prostate-specific antigen -0.1
urease -0.2
tyrosine hydroxylase -0.2
urease -0.2
protein kinase -0.3
guanylate cyclase -0.4
cytochrome oxidase -0.4
gamma-glutamyl transpeptidase -0.5
ACE -0.5
collagenase -0.5
lipase -0.5
creatine kinase -0.5
transcriptase -0.6
lysozyme -0.7
protein kinase C -0.9
AMPK -0.9
cholinesterase -1.0
AMP-activated protein kinase -1.0
ATPase -1.0
neuraminidase -1.2
NO synthase -1.3
RNase -1.3
DNA polymerase -1.4
RNase -1.5
MEK -1.5
phospholipase C -1.5
endonuclease -1.5
phosphodiesterase -1.5
aspartate aminotransferase -1.7
peroxidase -1.8
focal adhesion kinase -1.8
alanine aminotransferase -2.0
catalase -2.1
acetylcholinesterase -2.1
RNA polymerase -2.4
caspase-3 -2.5
luciferase -2.6
ACS -2.6
trypsin -2.7
mitogen-activated protein kinase -2.9
Compound
C18H22O3 11.7
HPT 9.7
4 PA 8.5
Deoxypyridinoline 7.2
Mithramycin 6.5
Alendronate 6.4
Alendronate 6.3
Pyridinoline 6.2
Pamidronate 6.2
Risedronate 6.2
vitamin D 6.2
25-dihydroxycholecalciferol 6.1
D 3 6.1
25-hydroxycholecalciferol 6.0
MTC 6.0
EHDP 5.9
Norethisterone 5.9
25-Hydroxyvitamin D 5.9
Fludrocortisone 5.8
SP 1 5.8
PHT 5.7
Calcitonin 5.7
BMD 5.7
myo-inositol 1-phosphate 5.4
4-pentenoic acid 5.4
POP 5.4
calcium 5.3
Vitamin D 5.3
DBM 5.1
DBM 5.1
Thiazide 5.0
HNS 4.9
Geigy 4.8
oxalate 4.7
Octreotide 4.7
phosphorus 4.6
creatinine 4.5
Akron 4.4
Mepyramine 4.4
ALP 4.3
Raloxifene 4.3
Hydroxyproline 4.1
K19 4.0
AIR 4.0
TGT 3.9
MEA 3.8
Cortisone 3.8
TBS 3.8
Uric acid 3.8
G11 3.7
Protoporphyrin IX 3.6
AME 3.6
DPA 3.6
Thyroid 3.6
DPA 3.6
Lithium 3.5
AMP 3.5
phosphate 3.4
DPA 3.4
DPA 3.4
MHPG 3.4
DPA 3.3
TET 3.3
TET 3.3
aldosterone 3.2
Wellcome 3.2
DPA 3.2
TAR 3.2
DPA 3.1
Estrogen 3.1
Estrogen 3.1
Quinidine 3.1
DPA 3.1
DPA 3.1
DPA 3.1
DPA 3.1
DPA 3.1
cAMP 3.1
DPC 3.0
DPC 3.0
BAP 2.9
Norton 2.9
Vitamin D3 2.9
MIT 2.9
MIT 2.9
Choline 2.8
Nodular 2.8
Methylene blue 2.8
HNO3 2.8
NEM 2.7
A 42 2.7
TMP 2.7
EDTA 2.7
Ketoconazole 2.7
PPi 2.7
TMP 2.7
TMP 2.6
carbonate 2.6
TRH 2.6
Bromocriptine 2.6
EDTA 2.6
CaCl2 2.6
A 71 2.5
Alizarin 2.5
phosphoric acid 2.5
Hydroxyurea 2.5
Belt 2.5
Verapamil 2.4
Oil Red O 2.4
SEE 2.4
Verapamil 2.4
DBP 2.3
Hypaque 2.3
TTS 2.3
Propranolol 2.3
delta-aminolevulinic acid 2.2
TSH 2.2
Propranolol 2.2
6-12 2.2
HPP 2.2
TMP 2.2
CTX 2.2
DBP 2.1
5-HIAA 2.1
BUdR 2.1
Nifedipine 2.1
Thyroxine 2.1
AHA 2.1
GAL 2.0
Prednisone 2.0
Tetracycline 2.0
Valproic acid 1.9
oxalic acid 1.9
HVA 1.9
strontium 1.9
Norepinephrine 1.8
LPC 1.8
Clin 1.7
PPI 1.6
Adrenal 1.6
ACTH 1.6
Angiotensin II 1.5
SET 1.5
iodine 1.5
Isoproterenol 1.5
Glycogen 1.5
His 1.4
Parenteral 1.4
PNA 1.4
Warfarin 1.3
DIC 1.3
Cortisol 1.2
urea 1.2
Insulin 1.2
DDD 1.2
CIT 1.2
Histamine 1.2
PPD 1.2
PGE 1.1
ETA 1.1
more...