Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0221002 (primary hyperparathyroidism)
 4,921 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
parathyroid hormone 1388
PTH 611
Sep 313
parathormone 271
alkaline phosphatase 206
calcitonin 139
chronic renal failure 131
She 121
HPT 90
osteocalcin 82
calcium-sensing receptor 79
MEN1 75
Parathyroid hormone 74
AMP 71
insulin 70
parathyroid hormone-related protein 68
albumin 63
MRI 60
parafibromin 55
RET 53
gastrin 48
thymus 44
CDC73 41
collagen 39
Pol 36
Mol 34
renin 34
FHH 33
menin 30
type I collagen 29
CaSR 27
calcium sensing receptor 27
BMD 26
cyclin D1 26
MEN2A 25
CDKN1B 22
reserved 22
RET proto-oncogene 22
prolactin 21
GFR 21
secretin 20
glucagon 20
vitamin D receptor 20
Calcitonin 18
growth hormone 17
serum albumin 16
somatostatin 16
p27(KIP1) 16
Osteocalcin 16
BGP 16
ZES 13
chromogranin A 13
ALP 13
thyroid hormone 12
Mal 12
p53 11
AP17 11
pancreatic polypeptide 11
acid phosphatase 11
tumour suppressor 10
proto-oncogene 10
type I procollagen 10
neurofibromatosis 10
FDG 9
PTH/PTHrP 9
catenin 9
sclerostin 9
glycoprotein 9
tartrate-resistant acid phosphatase 9
JAMA 9
ACTH 9
guanine nucleotide binding protein 9
CCND1 9
nodal 9
Alkaline phosphatase 8
Ki-67 8
CO2 8
cytokine 8
gut 8
p27 8
FGF23 8
PRL 8
GCMB 8
thyroglobulin 8
Parafibromin 8
PHP 8
CTX 7
ANOVA 7
MDP 7
adenylate cyclase 7
G protein-coupled receptor 7
RANKL 7
osteoprotegerin 7
hemoglobin 7
MRC 6
CYP24A1 6
Klotho 6
VDR 6
polypeptide 6
endoplasmic reticulum 6
EZH2 6
Wermer syndrome 6
kit 6
lymphoid 6
renal) 6
cage 6
NPS 6
lectin 6
osteosarcoma 6
neurofibromatosis type 1 5
MIP 5
amylase 5
TRH 5
ICD 5
CgA 5
angiotensin II 5
proximal tubule 5
RANK 5
Cyclin D1 5
calcium channel 5
serum protein 5
IL-6 5
ret 5
interleukin-6 5
phosphatase 5
synaptophysin 5
MTC 5
PTH1R 5
APC 4
atrial natriuretic peptide 4
ATPase 4
IgA 4
ENT 4
AMG 4
SMA 4
Menin 4
extracellular calcium-sensing receptor 4
IGF-I 4
osteonectin 4
VHL 4
vasopressin 4
Albumin 4
hemochromatosis 4
bone) 4
proton pump 4
PKA 4
Ang II 4
NF1 3
DBP 3
SBP 3
erythropoietin 3
LRP5 3
PRA 3
HLA 3
P-glycoprotein 3
Mil 3
beta-catenin 3
receptor tyrosine kinase 3
tumor suppressor protein 3
tumor necrosis factor 3
more...
Disease
primary hyperparathyroidism 4921
hypercalcemia 1638
adenoma 1457
hyperparathyroidism 1412
tumor 575
cancer 456
carcinoma 416
multiple endocrine neoplasia 353
osteoporosis 298
hypoparathyroidism 216
bone disease 200
Parathyroid 196
nephrolithiasis 194
hypertension 192
hypercalciuria 172
Parathyroid carcinoma 157
chronic renal failure 141
parathyroid hyperplasia 122
MEN1 122
diabetes 114
metastases 113
renal failure 111
vitamin D deficiency 104
medullary thyroid carcinoma 104
osteitis 98
hyperthyroidism 93
pheochromocytoma 87
PDB 82
osteomalacia 80
urolithiasis 78
endocrine disorder 78
pancreatitis 74
renal disease 73
multiple myeloma 67
nephrocalcinosis 67
depression 58
acute pancreatitis 53
goiter 52
renal insufficiency 51
sarcoidosis 51
hypercalcemia of malignancy 45
Best 44
peptic ulcer 43
HRPT2 42
MEN 2 40
cardiovascular disease 39
thyroid cancer 38
acromegaly 37
uremia 37
bone metastases 37
tumorigenesis 37
breast cancer 35
thyroid nodule 35
Parathyroid adenoma 33
renal osteodystrophy 33
thyrotoxicosis 33
pseudohypoparathyroidism 31
Brown tumor 30
hypothyroidism 30
renal tubular acidosis 30
Brown 30
tetany 28
SEM 28
rare disease 27
BMD 26
renal impairment 26
dehydration 26
rickets 25
lymphoma 24
Cushing's syndrome 24
anemia 24
Zollinger-Ellison syndrome 24
gastrinoma 24
Familial hypocalciuric hypercalcemia 22
pathological fracture 22
insulinoma 22
carcinoid 21
malabsorption 21
aldosteronism 21
multinodular goiter 21
neuroendocrine tumor 20
obesity 20
Graves' disease 20
prolactinoma 20
hyperoxaluria 19
chondrocalcinosis 19
pituitary adenoma 19
adenocarcinoma 18
hypogonadism 17
chronic pancreatitis 17
dysplasia 16
thyroid adenoma 16
glucose intolerance 16
essential hypertension 16
thyroiditis 16
chronic renal insufficiency 15
stroke 15
coma 15
pseudogout 14
gallstones 14
type 2 diabetes 14
confusion 14
MEN 2B 14
Conn 13
wasting 13
ventricular hypertrophy 13
pituitary tumor 13
fibroma 13
cystinuria 13
osteodystrophy 12
Burnett 12
sponge kidney 12
metabolic disorder 12
hypoglycemia 12
rheumatoid arthritis 12
myocardial infarction 12
hyperphosphatemia 12
parathyroid neoplasm 12
aggressiveness 12
OHD 11
Secondary hyperparathyroidism 11
Calciphylaxis 11
hypercortisolism 11
hyperprolactinemia 11
hypovitaminosis 11
heart failure 11
tuberculosis 11
myopathy 11
renal cell carcinoma 10
liver disease 10
duodenal ulcer 10
acute renal failure 10
dyspepsia 10
Nose 10
Cushing's disease 10
papillary thyroid cancer 10
arthritis 10
IRMA 10
azotemia 10
paraganglioma 10
metabolic alkalosis 10
Hippel 10
Familial hyperparathyroidism 10
dementia 9
Hyperplasia 9
epiphysis 9
neurofibromatosis type 1 9
psychosis 9
hyperlipidemia 9
disorders of calcium metabolism 9
hyperinsulinemia 9
Hashimoto's thyroiditis 9
Malignancy 9
genetic disorder 9
dysphagia 9
cold 9
cognitive impairment 9
gastritis 9
celiac disease 9
neurofibromatosis 9
more...
Symptom
weakness 101
fatigue 77
pain 75
anesthesia 75
bone pain 52
polyuria 51
nausea 45
vomiting 40
constipation 37
abdominal pain 35
anorexia 31
polydipsia 30
lethargy 26
arthralgia 17
diarrhea 16
nausea and vomiting 14
back pain 13
Ill 13
headache 13
renal colic 12
seizures 11
asthenia 10
dyspnea 9
myalgia 9
discomfort 9
discomfort 9
respiratory distress 9
hypotonia 9
epigastric pain 8
memory loss 8
hoarseness 7
knee pain 6
thinning 6
paresthesia 5
hepatosplenomegaly 5
low back pain 5
hip pain 4
ENT 4
neck pain 4
acute abdomen 4
hunger 4
colic 4
chest pain 4
agitation 4
cough 3
angina 3
dizziness 3
hyperemesis 3
flank pain 3
sleepiness 3
heartburn 3
exhaustion 3
Psychiatric symptoms 3
apathy 3
Gastrointestinal symptoms 3
Stiffness 2
cyanosis 2
numbness 2
dysarthria 2
consciousness disturbance 2
dysuria 2
sore throat 2
phosphatemia 2
ataxia 2
tingling 2
analgesia 2
hyperemesis gravidarum 2
shortness of breath 2
leg pain 2
paraparesis 2
splenomegaly 2
pallor 2
chronic constipation 1
lassitude 1
paresis 1
stridor 1
clubbing 1
syncope 1
lump in the neck 1
trigeminy 1
tonic-clonic seizure 1
aphonia 1
Physical findings 1
ketonuria 1
emaciation 1
tremor 1
fasciculation 1
abnormal gait 1
acidity 1
fever of unknown origin 1
renal pain 1
loin pain 1
Wind 1
oliguria 1
Postoperative vomiting 1
vertigo 1
collapse 1
masculinization 1
hepatomegaly 1
sciatica 1
Lhermitte's sign 1
atypical chest pain 1
acute pain 1
twitching 1
cachexia 1
shoulder pain 1
overweight 1
functional recovery 1
painful swallowing 1
ophthalmoplegia 1
thigh pain 1
jaw pain 1
catatonia 1
decreased appetite 1
abdominal discomfort 1
physical symptom 1
muscle cramps 1
ankle pain 1
generalized pain 1
stomach pain 1
Drug
PTH 621
Cinacalcet 45
APD 10
Nephron 10
Cardiovasc 10
Gel 9
Dial 9
CTX 7
CTX 7
Dermatol 7
Nephron 7
ENT 7
CTX 7
MRC 6
CaCl2 6
CaCl2 6
CaCl2 6
Cimetidine 5
Denosumab 5
MTC 5
Cimetidine 5
Albumin 4
Cinacalcet hydrochloride 4
EHDP 4
lysine 4
ROC 4
Leaf 3
Angiotensin II 3
Aredia 3
Estrogens 3
Clodronate 2
Spectrum 2
Ipriflavone 2
Methylene blue 2
Monit 2
Indocyanine green 2
Raloxifene 2
Zoledronic acid 2
Histamine 2
Dakar 2
Teriparatide 2
Growth hormone 2
Gallium nitrate 2
DPA 2
TAT 2
Growth hormone 2
IL-11 2
Calcifediol 1
Portal 1
TAC 1
Bonefos 1
ALA 1
Sandostatin 1
Rocaltrol 1
Hypaque 1
Fraction 1
CSF 1
G-CSF 1
PTC 1
nitroglycerin 1
Thyroglobulin 1
Prednisone 1
Indomethacin 1
DMSA 1
CAM 1
DDAVP 1
Serum albumin 1
Ammonium chloride 1
Chloramine T 1
Fluorescein 1
Ketoconazole 1
Sandostatin 1
Meditec 1
PCB 1
DM1 1
Calcium gluconate 1
DDAVP 1
Hypaque 1
ADM 1
Fluorescein 1
Zoledronic acid 1
HCG 1
Sorafenib 1
Ethanol 1
Diurnal 1
ETA 1
MEA 1
Enzyme
alkaline phosphatase 206
ERK 60
renin 34
acid phosphatase 11
protein kinase 10
adenylate cyclase 8
MDP 7
ATPase 5
MIP 5
APC 5
protein kinase C 4
PRA 3
peroxidase 3
P-glycoprotein 3
TAT 2
proline iminopeptidase 2
ACS 2
catalase 2
succinate dehydrogenase 2
focal adhesion kinase 2
creatine kinase 2
thyroid peroxidase 2
lysozyme 2
lipase 2
tyrosine hydroxylase 2
dihydropyrimidine dehydrogenase 2
ACE 2
collagenase 2
glucose-6-phosphate dehydrogenase 2
cathepsin K 2
mitogen-activated protein kinase 2
PHT 2
calcium pump 2
DNA methyltransferase 1
CYP3A4 1
cholinesterase 1
NO synthase 1
RNase 1
AMP-activated protein kinase 1
transcriptase 1
luciferase 1
NQO1 1
urease 1
ascorbate oxidase 1
phosphodiesterase 1
glyceraldehyde-3-phosphate dehydrogenase 1
RNA polymerase 1
kallikrein 1
phosphofructokinase 1
NADPH-diaphorase 1
diaphorase 1
asparaginase 1
phosphoglycerate kinase 1
guanylate cyclase 1
isoamylase 1
TGT 1
AMPK 1
aspartate aminotransferase 1
neuraminidase 1
cytochrome oxidase 1
caspase-3 1
endonuclease 1
E-2 1
ribonuclease 1
PDE 1
alpha-glucosidase 1
prostaglandin synthetase 1
alanine aminotransferase 1
MEK 1
urease 1
acetylcholinesterase 1
diaphorase 1
gamma-glutamyl transpeptidase 1
ribonuclease 1
phosphorylase kinase 1
1-hydroxylase 1
phospholipase C 1
CPT 1
RNase 1
homogentisate 1,2-dioxygenase 1
DNA polymerase 1
trypsin 1
hormone-sensitive lipase 1
prostate-specific antigen 1
GSK 1
Compound
calcium 2092
Clin 792
Dec 374
vitamin D 310
phosphate 296
creatinine 210
phosphorus 176
HPT 90
cAMP 77
DNA 74
AMP 71
sodium 58
glucose 57
oxalate 42
Vitamin D 40
water 37
aldosterone 36
His 33
potassium 29
Thyroid 28
carbonate 28
EDTA 27
BMD 26
25-dihydroxycholecalciferol 25
EDTA 25
urea 23
iodine 22
ethanol 19
Calcitonin 18
salt 17
arginine 14
Estrogen 14
ALP 13
Estrogen 13
nitrogen 12
methionine 11
TSH 11
Insulin 10
CO2 10
Dial 9
ACTH 9
phosphoric acid 9
POP 8
25-hydroxycholecalciferol 8
Lithium 8
Mg2+ 8
CTX 7
Alendronate 7
tyrosine 7
Alendronate 7
HCl 7
CaCl2 6
lysine 6
leucine 6
TRH 6
Cardiol 6
MTC 5
ammonium 5
6-12 5
tryptophan 5
oxygen 4
cGMP 4
Octreotide 4
Angiotensin II 4
EHDP 4
iron 4
noradrenaline 4
Adrenal 4
barium 4
proline 4
nitric oxide 4
NH2 4
Norepinephrine 3
TAR 3
Verapamil 3
acetic acid 3
Mithramycin 3
GAL 3
Isoproterenol 3
PGE 3
Propranolol 3
strontium 3
TEM 3
cysteine 3
Hydroxyproline 3
DBP 3
DBP 3
alanine 3
A 42 3
glutamine 3
Uric acid 3
Propranolol 3
Wellcome 3
nitrate 3
Verapamil 3
serine 3
silver 3
retinoic acid 3
Pamidronate 3
THP 2
Raloxifene 2
PPi 2
Choline 2
DPA 2
Norethisterone 2
isopropanol 2
CAT 2
DPA 2
methanol 2
DPA 2
TMP 2
MIT 2
TMP 2
PHT 2
DPA 2
Deoxypyridinoline 2
PGE2 2
Methylene blue 2
chlorine 2
oxalic acid 2
copper 2
Diabetol 2
tryptophan 2
TMP 2
A 71 2
zinc 2
Valproic acid 2
DPA 2
Ang II 2
DPA 2
ATP 2
ACS 2
TMP 2
L-DOPA 2
DPA 2
HNO3 2
aluminum 2
DPA 2
DBM 2
DPA 2
hydrogen 2
SEE 2
Thiazide 2
PAS 2
Asp 2
glutamate 2
acetate 2
DBM 2
Histamine 2
Cortisol 2
Nifedipine 2
Risedronate 2
tryptophan 2
aspartic acid 2
CAT 2
ACS 2
CAT 2
hydroxide 2
GTP 2
MIT 2
more...