Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0221002 (primary hyperparathyroidism)
 4,921 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Altered immunological reactivity in primary hyperparathyroidism is suggested by the strong association between this disorder and malignancy. The present study was carried out to determine whether altered lymphocyte proliferation in response to common mitogens (PHA, Con-A, PWM) exists in primary hyperparathyroidism, and, if so, whether the abnormality resides in the lymphocytes or in humoral factors present in the plasma of patients with hyperparathyroidism. Ficoll-Hypaque purified lymphocytes from 6 patients with primary hyperparathyroidism and 4 normal volunteers were stimulated with PHA, Con-A and PWM in the presence of plasma from patients with primary hyperparathyroidism and normal AB+ plasma. The incorporation of [3H]thymidine in unstimulated (control) and stimulated cultures was determined. The results demonstrate that lymphocyte proliferation was significantly higher when both patients' and normal lymphocytes were stimulated with mitogens in the presence of patients' plasma. These findings suggest that plasma from patients with primary hyperparathyroidism contains a potentiator of lymphocyte mitogenesis, or, alternatively lacks an inhibitor of lymphocyte activation that is present in normal plasma.
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PMID:Immunological aberration in primary hyperparathyroidism. 698 7

1,25-Dihydroxycholecalciferol [1,25(OH)2D], besides its role in calcium and phosphorus homeostasis, is also an important immunoregulatory molecule. Plasma levels of this hormone may be normal or elevated in patients with primary hyperparathyroidism. 1,25(OH)2D has been reported to inhibit production of the cytokines interleukin-2 (IL-2) and IL-6. In the present study, we examined the effect of parathyroid adenoma excision on serum IL-2 receptor (IL-2R) levels and the release and production of IL-2R and IL-6 by peripheral blood lymphocytes (each measurement was performed twice). Ten patients (5 females and 5 males aged 45 to 78 years) with primary hyperparathyroidism were enrolled in the study. The diagnosis of primary hyperparathyroidism was based on the presence of asymptomatic hypercalcemia, hypophosphatemia, and elevated serum intact PTH levels. Three weeks after removal of the parathyroid adenoma, there was a significant increase in the serum level of IL-2R, as well as the PHA-stimulated peripheral blood lymphocyte production of IL-6 and release of IL-2R. The results indicate that the removal of a parathyroid adenoma in patients with primary hyperparathyroidism causes a significant increase in IL-2R and IL-6 levels. The mechanism by which hyperparathyroidism may affect these cytokines and how they seem related to the levels of vitamin D is discussed.
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PMID:Effect of parathyroid adenoma excision on interleukin-6 (IL-6) and IL-2 receptor levels. 1069 Sep 43