Gene/Protein
Disease
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Drug
Enzyme
Compound
Pivot Concepts:
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Target Concepts:
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Query: UMLS:C0221002 (
primary hyperparathyroidism
)
4,921
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Forty-three cases of
primary hyperparathyroidism
were studied with the specific red cell adherence test (SRCA) to determine the presence or absence of
ABO
(H) cell surface antigens on abnormal parathyroid tissue. Of the 27 patients with the clinicopathologic diagnosis (CPD) of adenoma, 24 (89%) had lost the
ABO
(H) cell surface antigen of the abnormal gland. Among the 15 patients with the CPD of hyperplasia, the parathyroid tissue from three (20%) had lost its red cell antigen. In one patient, a metastasis from a parathyroid carcinoma had lost the
ABO
surface antigen. Several patients in whom conflicting SRCA and CPD were obtained had factors that raised doubts as to the validity of their CPD. The SRCA is a simple test that may aid in the difficult differentiation between parathyroid adenoma and hyperplasia.
...
PMID:ABO(H) cell surface antigens in parathyroid adenoma and hyperplasia. 701 89
This is an investigation into the finding that patients with
primary hyperparathyroidism
caused by Water Clear Cell Hyperplasia (WCCH) frequently belong to blood group O. Two control groups were defined from the same time period as 32 cases of WCCH treated at our clinic: one was a consecutive patient series with other forms of
primary hyperparathyroidism
(n = 864) and the other was the population in a geographically defined area in Sweden (n = 59,862). The blood group distribution of the patients with WCCH differed from the distribution of the patients with other forms of
primary hyperparathyroidism
with high significance (P = 0.00040). The blood group distribution did not differ between the two control groups. Strong associations between disease and HL-A type have previously been described, while associations found between disease and
ABO
blood groups were weaker. The association between WCCH and blood group O described here is by far the strongest association with the
ABO
system demonstrated to date. It is possible that the presence of an O-allele is a prerequisite for the development of WCCH.
...
PMID:Parathyroid water clear cell hyperplasia, an O-allele associated condition. 804 68
