Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0221002 (primary hyperparathyroidism)
 4,921 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Nineteen patients with histologically confirmed parathyroid adenomas were studied immediately before and 12 months after operation. The concentrations of 37 amino acids were estimated by chromatography in plasma and urine. In addition, proximal tubular function was studied by measuring the excretion of beta 2-microglobulin. No general aminoaciduria was registered either before or after operation but there were variations between preoperative and postoperative values in the plasma and urinary concentrations of a few amino acids. There were no correlations between preoperative and postoperative concentrations of calcium, parathyroid hormone or the various amino acids in plasma or urine. Nor was there any between the fall in serum calcium and the concentrations of the amino acids. There was no correlation between glomerular filtration rate and the amount of the different amino acids filtered. beta 2-Microglobulin excretion was normal both before and after operation in all but one patient. Aminoaciduria does not seem to be present in primary hyper-parathyroidism. Plasma and urinary concentrations of amino acids were unchanged after parathyroidectomy and proximal tubular function, assessed by measuring concentrations of amino acids in plasma and urine and urinary excretion of beta 2-microglobulin does not seem to be affected in primary hyperparathyroidism.
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PMID:Plasma and urinary amino acids as indicators of proximal tubular function in primary hyperparathyroidism. 168 72

We measured calcium, phosphate, chloride, albumin, C-terminal parathyrin, and beta 2-microglobulin in serum from 102 hypercalcemic patients: 42 with primary hyperparathyroidism and 60 with neoplasia. The calcium concentrations and the discriminant function index of Johnson et al. (Clin Chem 28, 333-338, 1982) were higher in malignant hypercalcemia than in primary hyperparathyroidism. The diagnostic efficiency of the index and of parathyrin concentration was 82% and 78%, respectively. Using the ratio of parathyrin to beta 2-microglobulin increased the diagnostic efficiency to 98%; the ratio of the discriminant index to parathyrin concentration had a diagnostic efficiency of 100%. We conclude that C-terminal assay by itself is no better than the discriminant function index.
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PMID:Value of measuring C-terminal parathyrin in differential diagnosis of hypercalcemia. 390 87

Parathormone has been shown to increase the secretion and production of lysosomal enzymes including tartrate-resistant acid phosphatase. All our 68 patients with proven primary hyperparathyroidism had signs of hyperparathyroid bone disease. Tartrate-resistant acid phosphatase and bone alkaline phosphatase activities are raised as a result of enhanced bone remodelling. Serum beta 2-microglobulin concentration in patients with primary hyperparathyroidism was normal 1.6 (1.4-1.8) mg/l versus 1.8 (1.7-2.2) mg/l in 51 control subjects. In hyperparathyroid patients, serum beta 2-microglobulin concentration does not correlate with plasma tartrate-resistant acid phosphatase activity which is known to be a sensitive biological marker of bone remodelling (r = 0.088). Our findings indicate that serum beta 2-microglobulin does not behave as a biological marker of remodelling in patients with enhanced remodelling in primary hyperparathyroidism.
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PMID:Beta 2-microglobulin does not behave as a biological marker of bone remodeling in patients with primary hyperparathyroidism. 987 25