Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
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Target Concepts:
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Query: UMLS:C0221002 (
primary hyperparathyroidism
)
4,921
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
The chronic effect of PTH on erythrocyte membrane Ca transport was examined. (Ca+Mg)ATPase activity and passive Sr influx were measured to assess the rate of passive Ca influx (total and inhibited by dihydropyridines [DHPs]), in erythrocytes from patients with
primary hyperparathyroidism
and normal controls. Erythrocyte Sr influx was lower in patients, due to a decreased
DHP
-sensitive Sr influx. Conversely, efflux activity of (Ca+Mg)ATPase was not different in patients and controls. We hypothesize that in
primary hyperparathyroidism
chronic PTH stimulation may induce a downregulation of the erythrocyte Ca influx mediated by
DHP
-sensitive Ca carrier.
...
PMID:Erythrocyte membrane calcium transport in patients with primary hyperparathyroidism. 806 Mar 33
