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Target Concepts:
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Query: UMLS:C0221002 (
primary hyperparathyroidism
)
4,921
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
To explain the incidence and significance of mitral and aortic valve calcification and calcific deposits in the myocardium, a prospective echocardiographic study was performed with 21 consecutive patients who had
primary hyperparathyroidism
(
PHP
) and with 21 age- and sex-matched control subjects with normocalcemia. Calcific deposits in the myocardium were seen in 13 patients (62%) with
PHP
, mainly in the interventicular septum, and in one control subject.
Aortic valve calcification
was observed in 12 patients (57%) with
PHP
and in one control subject. Calcification of the mitral valve was found in seven patients with
PHP
(33%) and three controls (14%). Calcification led to mild or moderate stenosis of the aortic valve in three patients with
PHP
and of the mitral valve in two patients with
PHP
. No stenosis was found in the subjects in the control group. Both calcification of the aortic and mitral valves and calcific deposits in the myocardium are common in patients with
PHP
and can be detected noninvasively by echocardiography. Because of the potential relationship of elevated calcium, calcification, and valvular heart disease, clinical evaluation of
PHP
should include echocardiographic studies before surgery is performed and during follow-up examination.
...
PMID:Cardiac calcific deposits in patients with primary hyperparathyroidism: preliminary results of a prospective echocardiographic study. 224 30
