Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0221002 (primary hyperparathyroidism)
 4,921 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Three studies have been undertaken to evaluate the predictive value for new stone formation of urinary calcium excretion. In study 1, 24-hr calciuria was similar in 52 patients with benign stone disease (less than 3 new stones or 1 staghorn calculus in the 5 preceeding years) and in 46 patients with severe lithiasis (more than 3 stones or 1 staghorn calculus), based on a retrospective assessment of stone disease evolution. In study 2, urinary fasting Ca/Creat was identical in 43 non-hyperparathyroid stone formers (including 31 with severe lithiasis) and in 35 patients with proven or suspected primary hyperparathyroidism (including 19 with benign lithiasis, 8 with severe lithiasis and 8 with no stone). In study 3, stone recurrence, assessed prospectively, felt significantly in patients given a high fluid intake alone or associated with 50 mg/d of hydrochlorothiazide, independently of urinary calcium excretion. Urinary calcium determination therefore appears useless for stone recurrence prediction.
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PMID:[Predictive value of lithogenic risk in hypercalciuria: should 24-hour urine calcium be measured?]. 653 Oct 63