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Query: UMLS:C0221002 (
primary hyperparathyroidism
)
4,921
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Two cases of
primary hyperparathyroidism
due to single parathyroid adenomas presented with the additional feature of hyperchloremic acidosis. The defect in urinary acidification responsible was not of the distal or gradient-limited type since both patients could lower urine pH adequately. However, there was a defect of bicarbonate reabsorption, an abnormality referred to as the proximal or rate-limited type of renal tubular acidosis. It is suggested that this defect represents an exaggeration of the physiological effect of parathormone on bicarbonate reabsorption and may be responsible for the frequent finding of
hyperchloremia
in association with
primary hyperparathyroidism
as well as for the urinary bicarbonate-wasting associated with a variety of causes of secondary hyperparathyroidism.
...
PMID:Primary hyperparathyroidism and proximal renal tubular acidosis: report of two cases. 501 29
Primary hyperparathyroidism
manifests biochemically as a disturbance in serum calcium homeostasis. The kidney appears to be the central organ that sets the serum calcium level.
Hyperchloraemia
, defective urinary acidification and renal tubular acidosis have been reported to be associated with
primary hyperparathyroidism
. Distal renal tubular acidosis due to
primary hyperparathyroidism
is rarely reported. Renal tubular dysfunction due to significant hypercalciuria appears to be one of the proposed mechanisms. This case report will highlight a case of
primary hyperparathyroidism
in a 26-year old Filipino man due to a solitary functioning parathyroid adenoma presenting with recurrent nephrolithiasis leading to distal renal tubular acidosis manifesting with hypokalaemia and hypomagnesaemia. The patient underwent a minimally invasive selective parathyroidectomy that resulted in full reversal of hypercalcaemia and hyperparathyroidism together with the features of distal renal tubular acidosis. He is currently on frequent follow-up for monitoring of electrolyte abnormalities and gradual resolution of nephrocalcinosis.
...
PMID:Distal renal tubular acidosis in primary hyperparathyroidism. 2563 59
Primary hyperparathyroidism
(PHPT) usually presents with hypercalcemia related symptoms and signs. Kidneys play an important role in calcium homeostasis. PHPT has been reported to be associated with
hyperchloremia
, defective urinary acidification, and renal tubular acidosis (RTA). The dysfunction of distal renal tubules is proposed to be secondary to calcium deposition in distal tubules. This case report highlights an initial presentation of parathyroid adenoma as hypokalemia due to distal RTA secondary to medullary nephrocalcinosis.
...
PMID:An initial evaluation of hypokalemia turned out distal renal tubular acidosis secondary to parathyroid adenoma. 3038 23
