Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0221002 (primary hyperparathyroidism)
 4,921 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Functioning parathyroid lipoadenoma (hamartoma) composed of abundant adipose or myxomatous stroma and epithelial cell nests is an unusual cause of primary hyperparathyroidism. We report herein four new cases. None of them belongs in the category of multiple endocrine neoplasia or familial hyperparathyroidism. The clinical manifestations and the laboratory findings are indistinguishable from those of the usual forms of primary hyperparathyroidism. Ultrasonography of the neck demonstrated an enlarged parathyroid gland as a hyperechoic mass in the two patients tested. At operation in each case, a single enlarged gland was found and resected, the weight being 3, 0.3, 0.45 and 1 g, respectively. The patients are normocalcemic 1 to 10 years after surgery. Pathological examination disclosed that the lesions were consistent with lipoadenoma or its variants. On reviewing 20 cases of functioning lipoadenoma which were reported in the literature, including the present cases, we found that the size of the tumors varied and a functioning lipoadenoma is hence by no means unusually large as previously reported. Without knowledge of this specific clinicopathologic entity, the lesion may be overlooked at the preoperative localization study and misdiagnosed as a normal or hyperplastic parathyroid.
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PMID:Functioning parathyroid lipoadenoma--report of four cases: clinicopathological and ultrasonographic features. 265 9

Lipoadenoma of the parathyroid gland is an unusual cause of primary hyperparathyroidism. Inasmuch as they may grossly resemble lipoma more than parathyroid adenoma, these tumors may be missed by surgeons and surgical pathologists alike. In this case, the diagnosis was made during surgery utilizing touch preparations because frozen sections were technically difficult to perform due to the fat content of the tumor. Examination of multiple sections disclosed a neoplastic proliferation of parathyroid cells, thus supporting the premise that this entity represented an adenoma rather than a hamartoma.
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PMID:Functioning parathyroid lipoadenoma. Report of a case diagnosed by intraoperative touch preparations. 375 27

Adenolipoma--or parathyroid hamartoma--has been described s a very rare lesion of the parathyroid gland, often unassociated with clinical hyperparathyroidism. A few reported cases in which the diagnosis was discovered pathologically following parathyroid resection for hyperparathyroidism have been called unique. In a 2-year period the diagnosis of parathyroid adenolipoma was made in three instances, with each clinical presentation consistent with primary hyperparathyroidism. In the first patient, a 64-year old man reporting to an emergency department for treatment of migraine headache, a prolonged history of unrecognized hypercalcemia was discovered, and he underwent cervical exploration. At operation, a 105 by 2.0 cm tumor weighing 17.5 gm was encountered. The other two patients were middle-aged women who had hypercalcemia (one requiring preoperative calcitonin treatment). The diagnosis of adenolipoma was made morphologically, although the clinical course was otherwise indistinguishable from other forms of primary hyperparathyroidism. Each of the three patients were cured following adenolipoma resection. This small series of patients in the experience of a single surgeon in a brief period might indicate that this diagnosis is by no means rare, and the functional nature of these tumors was the characteristic that brought them to diagnosis. The hypercalcemia was somewhat more severe in these cases--but the hyperparathyroidism was otherwise unremarkable. The morphologic features of these tumors include unusual size, proliferating fat content, and a fibrillar stroma. Adenolipoma of the parathyroid can cause primary hyperparathyroidism and should be considered in the differential diagnosis of the morphologic lesions of the parathyroid glands that can produce a hypercalcemic syndrome.
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PMID:Parathyroid adenolipoma: clinical and morphologic features. 713 1