Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0221002 (primary hyperparathyroidism)
 4,921 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The significance of PTH-radioimmunoassay was assessed in 63 surgically proven cases of primary hyperparathyroidism. To detect hyperparathyroidism, an increase in the free serum Ca index, [1-(8 X Alb + 2 X Glb + 3)/100] X Ca, has the highest predictive value (100%) for a positive test but a low predictive value (11.8%) for a negative test. It was necessary to improve the criteria to rule out the diagnosis of hyperparathyroidism. We therefore carried out a PTH radioimmunoassay employing kits made by CIS. The criteria for ruling out the diagnosis of hyperparathyroidism were that free serum Ca index was lower than 3 and PTH was lower than 4 mU/ml. The predictive value of these criteria for ruling out the diagnosis was 83.3%, significantly greater than the previously described criteria. Furthermore, the PTH concentration was significantly correlated to the weight of pathological parathyroid tissue surgically excised and to the free serum Ca index, although to a lesser extent than the latter. Thus, PTH-RIA is of value in improving diagnostic accuracy and in determining the severity of the disease.
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PMID:Significance of parathyroid hormone (PTH) radioimmunoassay in the diagnosis of primary hyperparathyroidism: an experience based on 63 surgically proven cases. 362 92

Cowden's disease is a well-described clinical syndrome, the primary symptoms of which are orocutaneous hamartomas and disseminated gastrointestinal polyposis. In general, the gastrointestinal polyps are benign, and the incidence of malignant transformation is believed to be low. Other associated manifestations of Cowden's disease include breast cancer and thyroid disease (benign and malignant). A patient with previously unrecognized Cowden's disease underwent upper gastrointestinal endoscopy for surveillance of hyperplastic gastric polyps, and a gastric carcinoma in situ was detected. During the course of follow-up the patient was found to have primary hyperparathyroidism resulting from a parathyroid adenoma. Although several benign proliferative and malignant conditions are associated with Cowden's disease, neither parathyroid adenoma nor gastric carcinoma has been reported previously.
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PMID:Parathyroid adenoma and gastric carcinoma as manifestations of Cowden's disease. 760 72