Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0220723 (PCA)
 4,687 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

When a group of 104 aged subjects was screened for autoimmune reactions, positive reactions for the rheumatoid factor and/or autoantibodies (ANA, anti-thyroid, PCA, anti-smooth muscle, anti-mitochondria) were recorded in 40.4%. Immunological functions were studied in 32 positive aged subjects, 32 age- and sex-matched negative controls, and 32 young subjects. Some differences attributable to the process of aging were quite evident, such as a depression in the percentage of E rosette forming peripheral lymphocytes and in their response to PHA, and an increase in the percentage of IgG-bearing peripheral lymphocytes and in the serum levels of IgA and three complement fractions (C'3, C'4, and C'3-PA). No clear-cut picture was noted when autoimmunity-positive and -negative, aged subjects were compared. However, some differences between sexes suggest that autoimmune reactions are linked to a depressed T cell function mainly in males, whereas the reverse is true for females.
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PMID:Immunological status of aged subjects with reference to serological evidence of autoimmunity. 30 69

Immunological properties of isepamicin (HAPA-B), a new semisynthetic aminoglycoside, were compared with those of gentamicin (GM). The results are summarized as follows. Rabbits were immunized by HAPA-B or GM with a strong adjuvant, Freund's complete adjuvant, and specific IgG antibodies were found in sera when assayed using PHA and PCA reactions. In sera from guinea pigs and mice immunized by HAPA-B or GM with aluminum hydroxide gel, no specific IgG nor IgE antibody was detected when assayed using PCA reactions. Specific antibodies (IgG, IgE) produced against HAPA-B and GM were confirmed in different animals immunized by chemically introduced antigens of HAPA-B-carrier protein conjugate and GM-carrier protein conjugate, respectively. Guinea pigs immunized by HAPA-B or HAPA-B-carrier protein conjugate with aluminum hydroxide gel did not exhibit typical systemic anaphylactic reactions when elicited with HAPA-B alone. HAPA-B had some immunocross-reactivity with GM. These results suggested that the antibody-producing activity of HAPA-B was similar to that of GM.
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PMID:[Immunological properties of isepamicin (HAPA-B)]. 356 Apr 42

The antigenicity of rokitamycin (TMS-19-Q, TMS) was studied. Rabbits and mice were repeatedly challenged with TMS emulsified with adjuvant to be strongly immunized. Neither IgG nor IgE antibodies were, however, detected in serum from these animals when assayed by PCA and PHA reactions. Furthermore, guinea pigs immunized with TMS together with Freund's complete adjuvant did not exhibit any systemic anaphylactic reactions when elicited with TMS alone. In contrast, specific antibody production against TMS was confirmed in animals immunized with chemically introduced antigen of TMS-carrier protein conjugate, where TMS had antigenic nature as hapten.
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PMID:[Antigenicity study of rokitamycin]. 361 81

Distinct populations of human B lymphocytes can be identified by their expression and/or co-expression of the B cell-restricted antigens B1 and B2. Dual fluorochrome staining and flow cytometric cell sorting permitted the isolation of the B1+B2+ and B1+B2- cells to homogeneity. In contrast, very few B1-B2+ cells were obtainable from normal lymphoid organs. Virtually all B1+B2+ cells expressed IgM and IgD, but lacked IgG and the plasma cell antigens PCA-1 and PC-1, whereas the B1+B2- cells more frequently expressed IgG, PCA-1 and PC-1. Both populations were noncycling and were composed of similar percentages of small and large cells. The B1+B2+ cells proliferate to anti-mu or to anti-mu + PHA-LCM, but not to PHA-LCM alone. They require both T cells and PWM to produce Ig. In contrast, B1+B2-cells do not significantly proliferate to anti-mu, PHA-LCM, or anti-mu and PHA-LCM. They produce Ig in response to T cells alone without PWM. These phenotypic and functional observations provide preliminary evidence that these populations are distinct and that the B1+B2+ cell may be a "resting" B cell, whereas the B1+B2- cell appears to be more "differentiated." The present studies further suggest that they will also be helpful in characterizing B cells in some human disease states. We believe that the identification and isolation of these and similar subsets of B cells defined by differing cell surface phenotype should aid our understanding both of normal B cell differentiation and of B cell disease states.
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PMID:Isolation and functional analysis of human B cell populations. I. Characterization of the B1+B2+ and B1+B2- subsets. 391 76

Studies on antigenicity of suloctidil were performed on ASA, Schultz-Dale reaction, PCA and PHA in guinea pigs. Two sensitizing procedures were enforced. One was performed by means of treatment of suloctidil (p. o. and i. p.) and the other was done by means of injection of suloctidil, suloctidil-BSA-mixture and suloctidil-BSA-conjugate emulsified with FCA. Guinea pigs treated with suloctidil by oral or intraperitoneal administration showed no ASA, Schultz-Dale reaction, PCA and PHA by the challenge of suloctidil. The animals treated with suloctidil-BSA-conjugate only evoked severe anaphylactic reaction to challenge of suloctidil-OVA-conjugate. Guinea pigs treated with suloctidil and suloctidil-BSA-mixture showed no anaphylactic reaction to challenge of suloctidil, suloctidil-OVA-mixture and suloctidil-OVA-conjugate. The animals sensitized with suloctidil-BSA-conjugate showed no anaphylactic reaction to challenge of suloctidil and suloctidil-OVA-mixture. Therefore, it is concluded that suloctidil does not have any antigenicity.
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PMID:[Antigenicity of suloctidil]. 631 26

The release of procoagulant material by connective tissue cells as a sequel to cell injury can initiate blood coagulation and may thus play a role in he pathogenesis of inflammatory lesions. Human foreskin fibroblasts were shown to synthesize high levels of the procoagulant TF in vitro. Generation of TF by fibroblasts was inhibited by addition of supernatants of PHA-stimulated human mononuclear cells to fibroblast cultures. The inhibition was independent of supernatant effects on cellular proliferation and was accompanied by up to a 20-fold increases in PGE2 synthesis in the fibroblast cultures. The inhibition of TF generation by MC-SNs was reversed by adding indomethacin to the fibroblast cultures, suggesting that mononuclear cells suppress fibroblast TF generation by stimulation of endogenous fibroblast synthesis of prostaglandin. Regulation of fibroblast PCA by products of immune cells may be important in the pathogenesis of inflammatory lesions.
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PMID:Mononuclear cell modulation of fibroblast procoagulant activity. 695 Sep 92

Lectins have been used to study populations and discrete differentiation stages of lymphocytes. Likewise, lectins have been of practical importance in promoting mitogenic stimulation of lymphocytes in numerous species. In this research project, we took advantage of these tools in an attempt to identify specific subsets of peripheral blood lymphocytes obtained from healthy nine-banded armadillos (Dasypus novemcinctus). The same cell source served to evaluate mitogenic stimulation. Twelve FITC-labeled lectins were used; 5 (ConA, LcH, RCA, WGA and UEA) reacted with almost 100% of the lymphocytes and 7 (PNA, DBA, SBA, PCA, PHA-L, PWM and VVA) recognized variable percentages (< 100% of these cells). This latter group of lectins may be useful in the identification of armadillo lymphocyte subsets, or may correlate with discrete stages of differentiation of these cells. The same lectins served to evaluate mitogenic stimulation in an aliquot of the same peripheral blood mononuclear cells. Of the 12 lectins studied, 5 (ConA, PHA-L, PWM, DBA and SBA) had the capacity to induce mitogenic stimulation in the whole mixture of mononuclear cells, giving rise to variable degrees in the corresponding mitogenic index obtained for each of the 5 lectins. Those lectins that gave an indication of selective identification of lymphocytes, that is, the percentages at or below 75%, may prove useful in the evaluation of the immune response of healthy armadillos as well as the evolution of progression stages of lepromatous leprosy in armadillos inoculated with the same strain of Mycobacterium leprae that affects humans.
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PMID:Immune response of armadillos (Dasypus novemcinctus). I. Use of lectins to identify lymphocyte subpopulations and to evaluate cell proliferation. 864 18