Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0220723 (
PCA
)
4,687
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
In the process of biological knowledge discovery,
PCA
is commonly used to complement the clustering analysis, but
PCA
typically gives the poor visualizations for most gene expression data sets. Here, we propose a
PCCF
measure, and use
PCA
-F to display clusters of
PCCF
, where
PCCF
and
PCA
-F are modeled from the modified cumulative probabilities of genes. From the analysis of simulated and experimental data sets, we demonstrate that
PCCF
is more appropriate and reliable for analyzing gene expression data compared to other commonly used distances or similarity measures, and
PCA
-F is a good visualization technique for identifying clusters of
PCCF
, where we aim at such data sets that the expression values of genes are collected at different time points.
...
PMID:The biological knowledge discovery by PCCF measure and PCA-F projection. 2839 80
