Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0220723 (PCA)
 4,687 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Disodium cromoglycate (DSCG) and RS 7540 both inhibited the rat PCA reaction mediated by mouse IgE; RS 7540 was more potent. RS 7540 showed self- and cross-tachyphylaxis with DSCG and failed to protect rat mast cells against desensitization induced by antigen. In the guinea pig ileum test, DSCG reduced stimulation by various spasmogens, whereas RS 7540 even at high doses was inactive. These differences suggest that RS 7540 has major deficiencies as a potential alternative to DSCG in the treatment of bronchial asthma.
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PMID:Antiallergic action of disodium cromoglycate and xanthone RS 7540. 613 6

Ro 21-7634 was examined for oral antiallergic activity in two in vivo models commonly used to evaluate antiallergics. In the rat PCA test, this drug had an oral ID50 of 1.14 mg/kg and was found to be more potent than several other antiallergics including Disodium Cromoglycate (cromoglycate), Oxatomide, Doxanthrazole, Xanoxate, 2,6-bis (ethyoxyoxalylamino) pyridine, PRD-92-EA and M + B 22,948. In contrast to cromoglycate, Ro 21-7634 was found to be an orally active inhibitor of antigen-induced broncho-constriction in passively sensitized rats (ID50 = 0.2 mg/kg). In addition, Ro 21-7634 inhibited antigen-induced histamine release in an in vivo passive peritoneal anaphylaxis test system, following intraperitoneal administration. Ro 21-7634 demonstrated no end organ antagonism toward histamine, metacholine or serotonin in the guinea pig.
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PMID:Ro 21-7634, a new antiallergic agent with potent oral activity. 702 96