Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0220723 (
PCA
)
4,687
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Piceatannol
(3,3',4,5'-tetrahydroxy-trans-stilbene;
PCA
) is a naturally occurring metabolite of resveratrol (3,4',5-trihydroxy-trans-stilbene; RV). In this study, we identified additional biochemical targets of
PCA
in human HL-60 promyelocytic leukemia cells. Incubation with
PCA
led to a significant proportion of apoptotic cells and caused an arrest in the G2-M phase of the cell cycle.
PCA
depleted intracellular dCTP and dGTP pools, and inhibited the incorporation of 14C-labeled cytidine into DNA.
PCA
significantly abolished all NTP pools, and sequential treatment with
PCA
and Ara-C yielded synergistic growth inhibitory effects because of remarkably increased Ara-CTP formation after
PCA
preincubation. Due to these promising results,
PCA
may support conventional chemotherapy of human malignancies and therefore, deserves further preclinical and in vivo testing.
...
PMID:Biochemical effects of piceatannol in human HL-60 promyelocytic leukemia cells--synergism with Ara-C. 1881 4
