Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0220723 (
PCA
)
4,687
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
IgG1, antibody-mediated homologous passive cutaneous anaphylaxis at 1.5 h (1.5-hour
PCA
) was elicited in the ears of mice and the effects of different drugs were studied. The reaction, as measured by the amount of extravasated dye, was inhibited by antihistamines, antiserotonins, cyclic AMP-elevating agents, tranilast and ketotifen, but not by an SRS-A antagonist (
FLP
55712), lipoxygenase inhibitors, cyclooxygenase inhibitors and disodium cromoglycate. These results suggest that the pharmacological profile of 1.5-hour
PCA
resembles that of 48-hour
PCA
mediated by IgE antibody in the mouse ear.
...
PMID:Effects of different drugs on passive cutaneous anaphylaxis elicited in the mouse ear at 1.5 hours. 245 88
