Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0220723 (PCA)
 4,687 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

This airticle combines the principal component analysis with persistent homology for applications in biomolecular data analysis. We extend the technique of persistent homology to localized weighted persistent homology to fit the properties of molecules. We introduce this novel PCA in the study of the folding process of residues 1-28 of amyloid beta peptide in solution. We are able to determine 7 metastable states of amyloid beta 1-28 using homology of dimension 2, corresponding to 7 local minimums in the free energy landscape. We also give the transition information between the 7 types and the disconnectivity graph. Our result is very robust under change of parameters. Furthermore persistent homology of dimension 1 also give consistent results. This method can be applied to different peptides and molecules. This article is protected by copyright. All rights reserved.
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PMID:Persistent homology and application on residues 1-28 of amyloid beta peptide. 3324 77