Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
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Enzyme
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Query: UMLS:C0220723 (
PCA
)
4,687
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Serotonin lesioning studies were performed to determine the synaptic localization of the
5-HT1D
receptor. Four days following p-chloroamphetamine (
PCA
; 5 mg/kg x 4) [3H]paroxetine-labeled uptake sites (a marker for 5-HT terminals) were reduced to 18% of control values in the cortex and 29% of control values in the striatum, while the number of
5-HT1D
receptors remained unchanged. Fourteen days following
PCA
administration an up-regulation of cortical
5-HT1D
receptors was observed. These findings indicate that
5-HT1D
receptors are localized postsynaptically in the cortex and striatum, and that denervation of endogenous serotonergic input produces a compensatory up-regulation in the cortex.
...
PMID:Postsynaptic localization and up-regulation of serotonin 5-HT1D receptors in rat brain. 252 33
