Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0220723 (PCA)
 4,687 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

The authors studied changes of LV dP/dt during transcutaneous coronary angioplasty (TCA). The aim of the study was to detect the alterations of LV function during coronary occlusion and to evaluate the immediate effects of PCA on myocardial function. Six patients with incapacitating angina and isolated left anterior descending disease were successfully treated by TCA using Gruntzig's technique. The study protocol included several recording sequences per patient during the phases of balloon inflation at progressively increasing pressures from 2 to 10 hours. Each sequence comprised a recording under basal conditions and every 5 seconds during inflation (20 seconds) and deflation (45 seconds) of the following parameters: heart rate, aortic and LV pressures, positive and negative peaks of LV dP/dt, and the intracoronary pressure gradient at the beginning and the end of each sequence. The first part of the results based on 27 recorded sequences analysed the bad effects of myocardial ischaemia; coronary occlusion induced a significant fall (p less than 0.01) in the positive and negative peak dP/dt values and on elevation (p less than 0.01) in LV end diastolic pressure, without affecting LV systolic pressure or heart rate. These changes have the following characteristics: they are early, occurring within seconds of coronary occlusion; they affect LV contraction and relaxation simultaneously, but the effects are more marked on LV relaxation; the severity is proportional to the duration of occlusion; they are totally reversible; the disturbances of relaxation return to normal more quickly than those of contraction.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:[Changes in left ventricular dP/dt during transluminal coronary angioplasty]. 315 68

Metabolomic profiling is ideally suited for the analysis of cardiac metabolism in healthy and diseased states. Here, we show that systematic discovery of biomarkers of ischemic preconditioning using metabolomics can be translated to potential nanotheranostics. Thirty-three patients underwent percutaneous coronary intervention (PCI) after myocardial infarction. Blood was sampled from catheters in the coronary sinus, aorta and femoral vein before coronary occlusion and 20 minutes after one minute of coronary occlusion. Plasma was analysed using GC-MS metabolomics and iTRAQ LC-MS/MS proteomics. Proteins and metabolites were mapped into the Metacore network database (GeneGo, MI, USA) to establish functional relevance. Expression of 13 proteins was significantly different (p<0.05) as a result of PCI. Included amongst these was CD44, a cell surface marker of reperfusion injury. Thirty-eight metabolites were identified using a targeted approach. Using PCA, 42% of their variance was accounted for by 21 metabolites. Multiple metabolic pathways and potential biomarkers of cardiac ischemia, reperfusion and preconditioning were identified. CD44, a marker of reperfusion injury, and myristic acid, a potential preconditioning agent, were incorporated into a nanotheranostic that may be useful for cardiovascular applications. Integrating biomarker discovery techniques into rationally designed nanoconstructs may lead to improvements in disease-specific diagnosis and treatment.
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PMID:Bioengineering silicon quantum dot theranostics using a network analysis of metabolomic and proteomic data in cardiac ischemia. 2401 56