Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0206061 (
interstitial pneumonia
)
6,105
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
SRL
, an mTOR inhibitor that inhibits cell cycle progression, represents an important alternative to CNIs, which are still the cornerstones of pediatric solid organ tx. Because there are still limited data on
SRL
use among pediatric solid organ recipients, further studies are needed to verify the efficacy and safety of
SRL
. It has unique pharmacokinetic characteristics concerning dosing intervals and reduction of the dose in combination with other immunosuppressants.
SRL
also has antineoplastic, antiviral, and antiatherogenic advantages over other immunosuppressive agents. The adverse effects of
SRL
including thrombocytopenia, hyperlipidemia, proteinuria, impaired wound healing, mouth ulcers, edema, male hypogonadism, TMA, and
interstitial pneumonitis
must be considered carefully in pediatric population. This article reviews the most recent data on
SRL
application in the field of pediatric renal tx.
...
PMID:Sirolimus in pediatric renal transplantation. 2200 42
