Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0206061 (
interstitial pneumonia
)
6,105
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Propylthiouracil
(
PTU
) is a drug used to treat hyperthyroidism. A number of adverse effects have been reported with this drug, including fever, agranulocytosis, skin rash, and vasculitis.
PTU
-induced
interstitial pneumonia
is rare--only three cases have been reported--and
PTU
-induced nonspecific
interstitial pneumonia
(NSIP) has not been reported. We report a patient who developed NSIP after taking
PTU
for 1 year. She developed dyspnea, cough, and mild fever lasting 1 month, and a chest CT scan showed multifocal patchy consolidation in both lungs. She underwent a surgical lung biopsy, and NSIP was confirmed pathologically. The symptoms and abnormalities seen in the chest radiograph improved after withdrawal of
PTU
. To our knowledge, this is the first documented case of pathologically proven
PTU
-induced NSIP.
...
PMID:Propylthiouracil-induced nonspecific interstitial pneumonia. 2136 56
