Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0206061 (interstitial pneumonia)
 6,105 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

A retrospective study was conducted of all feline necropsies over a 7-year period. Of a total of 1,472 necropsies, 37 cases of endomyocarditis (EMC) and 25 cases of left ventricular endocardial fibrosis (LVEF) (previously called restrictive or intermediate cardiomyopathy) were identified. There was a subset of four cats with EMC that had histologic features of both diseases. Interstitial pneumonia was seen in 25 of 35 cats (71%) with EMC but in only seven of 25 cats (28%) with LVEF. Thrombi or thromboemboli were seen in 14 of 25 cats (56%) with LVEF but in only six of 37 of cats (16%) with EMC. In both LVEF and EMC, thromboemboli were located in the abdominal aorta, left atrium and ventricle of the heart, femoral artery, cranial mesenteric artery, liver, pulmonary artery, jugular vein, or a meningeal vessel. Each cat had a single thrombus/thromboembolus, except for four cats with LVEF that had more than one. The histologic and clinical findings suggest that EMC and LVEF represent temporally different manifestations of a single disease entity.
 ...
PMID:Feline endomyocarditis and left ventricular endocardial fibrosis. 777 Oct 51

The aim of this study was to characterize the main vascular lesions seen in the saline controls in continuous infusion studies in monkeys. Data were collected from 17 studies over an 8-year period (ie, around 50 males and 50 females). The study was restricted to lesions at the injection site, in lungs and at the entry point. It showed that the level of the most severe procedure-related lesions (ie, necrosis with abscess formation at the injection site and at the entry point, thromboemboli and probable infarcts in lungs) was low (<10%). Minor changes such as endothelial hyperplasia and intimal thickening at the injection site, and low-graded interstitial pneumonitis in lungs were the most frequent changes (40 to 50% of the animals). Thrombi at the injection site were present in around 30% in males and 40% in females. The slightly higher incidence of thrombi in females was not explained by a difference of vessel size or by hematological differences. This study permitted an opportunity to harmonise terminology among pathologists and to define the main procedure-related changes and their incidence, which could help pathologists better interpret changes in future infusion studies.
 ...
PMID:Main vascular changes seen in the saline controls of continuous infusion studies in the cynomolgus monkey over an eight-year period. 1274 14