Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0205700 (ash)
 15,125 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Various aspects of the effect of estradiol benzoate (EB, Agofollin Depot, Czechoslovakia, usually in a s.c. dose of 5 mg/kg body weight once a week), on the local circulation (the uptake of 85Sr-microspheres), the incorporation of 45Ca and 3H-proline, bone density and ash weight related to bone volume were studied in six experiments in the tibia and distal femur of 224 rats. 1. The dose-response. In rats treated four weeks with doses of 0.5, 1.0, 1.5 and 2.0 mg EB per rat once a week, a significant correlation with the uptake of 85Sr-microspheres (r = -0.56), the blood flow (r = -0.56), the incorporations of 45Ca (r = -0.89) and 3H-proline (r = -0.35) and body weight (r = -0.71) was demonstrated. 2. The time course of changes after 1, 2, 4 and 8 weeks administration of EB. Circulatory values were not significantly lowered until after four weeks, 45Ca incorporation and body weight were significantly lower after only one week and 3H-proline incorporation did not fall until after eight weeks. The course of the uptake of 85Sr-microspheres and the incorporation of 45Ca were very similar. 3. Comparison of males and females. EB reduced circulatory values and 45Ca and 3H-proline incorporation and increased bone density and bone ash weight in both males and females. Conclusions. The decrease in the local bone blood flow after EB showed a significant dose-effect correlation; the decrease in circulatory values, on using the given administration method, is significant after four weeks. The inhibitory effect of EB on the bone blood flow is not sex-specific.(ABSTRACT TRUNCATED AT 250 WORDS)
 ...
PMID:Further findings on the inhibitory effect of estradiol benzoate on the circulation and on 45Ca and 3H-proline incorporation in rat bones. 130 65

The authors submit the results of investigations of the action of oestrogens on the blood flow in bones and other tissues of female rats (by means of 85Sr microparticles) on the incorporation of 3H-proline and 45Ca into bone marrow and on bone density and weight of the ashes. Daily s.c. injections of oestradiol dipropionate (Agofollin Spofa, CSFR, 0.1 mg per 100 g) reduce the blood flow in the tibia already on the first days and significantly on the 9th day of administration. After four injections of oestradiol benzoate with protracted action (Agofollin Depot Spofa, 1 mg.s.c. once a week) the retention of 85Sr microparticles is significantly reduced in the distal epiphysis of the femur, in both terminal portions of the tibia and in vertebrae; the blood flow is significantly reduced in the distal epiphysis of the femur and in the proximal end of the tibia. Among various soft tissues where measurements were made only in the kidneys a significant drop of the local circulation was recorded. Twenty-four hour incorporation of 3H-proline and 45Ca into the tibia is significantly reduced after depot oestradiol benzoate. Under the same conditions an inconstant significant rise of bone density or weight of the ash per volume of bone was found. Oestrogen administration to female rats thus causes a drop of the local circulation in bones, in particular in trabecular tissue (among soft parts only in the kidneys) and at the same time a reduced formation of bone matrix and the process of mineralization. So far we are unable to explain the mechanism and impact of the observed reactions.
 ...
PMID:[Reduced blood flow in bones in female rats after administration of estrogen]. 204 38

We studied changes in the local circulation and mineralization of the rat tibia under different experimental conditions. Four experiments were performed on a total of 155 female and male rats: after oophorectomy (OOX) or orchidectomy (ORX), after the administration of estradiol benzoate (EB, Agofollin Depot, 1 mg/rat once a week or 5 mg/kg body weight once every 5 days for 4 weeks), or after the administration of testosterone (T, Agovirin Depot, 25 mg/kg body weight once every 5 days for 4 weeks). We estimated 85Sr-microsphere uptake and blood flow in the tibia, density of the tibia, and ash weight per bone volume unit. The scheme of the experiments was uniform: experiment A--females--controls, OOX, EB, OOX + EB; experiment B--males--controls, ORX, EB, ORX + EB; experiment C--females--controls, OOX, T, OOX + T; experiment D--males--controls, ORX, T, ORX + T. A sham operation was performed on the animals in the uncastrated groups. The results showed that OOX and ORX stimulated the uptake of 85Sr-microspheres and bone blood flow and reduced both bone density and ash weight, whereas T inconstantly and EB constantly reduced 85Sr-microsphere uptake and bone blood flow and increased bone density and ash weight in both sham-operated and castrated animals. The described changes in the bone blood flow and mineral content under the given experimental conditions suggest a relation in the regulations of both processes, a possible association with resorption of bone, and the importance of the circulation of blood in the metabolism of bone tissue.
 ...
PMID:Blood flow and mineral content of the tibia of female and male rats: changes following castration and/or administration of estradiol or testosterone. 774 86

Force-molted White Leghorn laying hens were implanted with 0.25, 0.5, 1 and 3 Compudose 200 pellets (24 mg 17 beta estradiol/pellet). Plasma estradiol increased with increasing E2 dosages in a linear manner and decreased over time in a quadratic manner (P < 0.01). E2 treatment had a nonlinear effect on total plasma calcium. Oviduct weight, shell thickness and egg weight were not significantly affected by exogenous estradiol whereas tibial bone ash percentage was increased at only one dose (P < 0.05:0.5 pellet group). Physiological supplementation with estradiol does not improve shell quality.
 ...
PMID:Effect of estrogen on egg production, shell quality and calcium metabolism in molted hens. 774 4

Four experiments on 76 female and 79 male rats were performed in which we followed up the effect of four weeks' administration of estradiol benzoate (Agofollin Depot 1 mg per rat once a week or 5 mg per kg once every 5 days s. c.) and testosterone isobutyrate (Agovirin Depot 25 mg per kg once every 5 days s. c.) on the local circulation in the tibia and distal femur (by means of 85 Sr-microsphere uptake) and on bone density and ash weight related to bone volume. Local circulatory values increase in the bones after oophorectomy (OOX) and orchidectomy (ORX) and decrease after estradiol in sham-operated rats of both sexes; testosterone inconstantly reduces the 85Sr-microsphere uptake in the bones of sham-operated male rats. Estradiol decreases local circulatory values in OOX females and ORX males to the level observed in sham-operated animals. Testosterone has a similar inhibitory effect in ORX males as estradiol; less pronounced, but statistically significant lowering occurs also in the tibia of OOX females. Density of the tibia and ash weight related to bone volume unit falls after OOX and ORX and rises constantly after estradiol; after testosterone administration, it does not change in sham-operated rats and OOX females, but rises in ORX males. Probably the most important finding is that also testosterone reduces local circulation in the bones of rats, though less regularly and less markedly than estradiol (in the dosage used).
 ...
PMID:[Local blood circulation and bone mineral content in the bones of rats: the effect of castration, estradiol and testosterone in male and female rats]. 797 16

After six weeks' administration of estradiol benzoate (Agofollin Depot, 1 mg s.c. once a week) we determined in the first part of 70 days old female rats the uptake of 85Sr-microspheres and local blood flow in the tibia, in the second part 24 hours' incorporation of 45Ca and 3H-proline and in the third part 2 hours' uptake of 85Sr, bone density and ash weight related to 1 ml of bone volume. We observed the following statistically significant changes: decrease in the uptake of 85Sr-microspheres and local blood flow, decrease in the incorporation of 45Ca, 3H-proline and 85Sr, increase in the density and ash weight of the tibia. The rise of bone mineral content simultaneously with reduced indicators of bone formation and particularly of the mineralization seems to be in the connection with the suppression of bone resorption under the influence of estrogen. Qualitatively identical reactions of circulatory and metabolic indicators to the administration of estradiol may be a reflection of mutual physiological interconnections.
 ...
PMID:[Local blood circulation, uptake of 45Ca, 85Sr and 3H-proline and mineral levels in the tibia of female rats: comparison and changes after administration of estradiol]. 797 17