Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0205700 (
ash
)
15,125
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Characteristic echocardiographic features of hypertrophic obstructive cardiomyopathy were recorded in 24 patients, all of whom had
asymmetric septal hypertrophy
and systolic anterior motion of the mitral valve (SAM) at rest or after pharmacodynamic stimulation. The relationship between outflow tract obstruction and SAM was assessed by comparison with data obtained at cardiac catheterisation and external mechanography: SAM seems to be a non-specific phenomenon and may be recorded in cases of hypertrophic cardiomyopathy without obstruction during pharmacodynamic stimulation. In forms with obstruction, SAM and the severity of obstruction increase with the degree of spetal hypertrophy. The increased contractility of the left ventricular posterior wall appears to be an important factor in the mechanism of SAM which can be prevented by betablockade in moderate or labile forms. When SAM is permanent, whatever the gradient recorded, it is a sign of anatomical deformation of the left ventricle and may be an additional indication for cardiac surgery.
Arch
Mal
Coeur Vaiss 1979 Apr
PMID:[Echocardiographic diagnosis of obstructive myocardiopathies: study of the systolic anterior motion of the mitral valve and septal hypertrophy as compared with the hemodynamic and mechanographic findings. Evolution under medical treatment]. 3 61
Three cases of symptomatic
asymmetric septal hypertrophy
are reported. The echocardiogram allows a reliable diagnosis; it entails no risk to the patient and it may be repeated during the course of the disease. Associated with biventricular angiocardiography, the echocardiogram represents the method of choice in detecting these lesions.
Arch
Mal
Coeur Vaiss 1977 Jun
PMID:[Asymmetric septal hypertrophy. Echocardiographic and angiographic diagnosis]. 14 55
Measurement of the bone trabicular volume (BTV) of 60 iliac crests obtained at necropsy, was done by morphometry on decalcified bone preparation. Changes in the site and the techniques of biopsy introduce variations which may reach 50% for sites which are one or two centimeters apart. The iliac bone is not especially imprecise and should be replaced by the transfixing horizontal biopsy. For a given zone, one observes a good correlation between the BTV and the
ash
weight per cubic centimeter of psongious bone, a point which justifies the interest in morphometry for the evaluation of the body bone mass.
Rev Rhum
Mal
Osteoartic 1978 May
PMID:[Critical study of variations in bone mass measurement by iliac biopsy]. 67 20
The aim of this study was to validate an echocardiographic method of evaluating LV mass by assessing the reproducibility and comparing the results with those of angiography. 20 patients without abnormal regional wall motions or
asymmetric septal hypertrophy
underwent left ventriculography in the RAO plane and three successive M mode and 2D echocardiograms. Three 2D echo methods of measuring volumes and mass were used: the monoplane ellipsoid model obtained from apical views, the biplane ellipsoid model from an apical and a short axis parasternal view and the hemi-ellipsoid-cylinder model (HEC). The M mode evaluations showed good reproducibility with respect to volume (variation coefficient (VC): inter observer 9.8 p. 100 and intra patient 15.6 p. 100). The reproducibility of 2D echo measurements was much poorer (intra patient volume: VC = 34 to 45 p. 100; mass 29 to 46 p. 100). A close correlation was observed between the results of M mode echo and angiography; volume r = 0.85, SD = 60 g. With respect to the 2D method, the best results were obtained with the HEC model; volume r = 0.90, SD = 31 ml; mass r = 0.82, SD = 41 g. We suggest a method combining the M mode and 2D techniques, using a HEC model in which the long axis is obtained by 2D echocardiography and the short axis and wall thickness by M mode recordings. The following correlations with the angiographic method were obtained: volume r = 0.91, SD = 36 ml; mass r = 0.89, SD = 27 g.(ABSTRACT TRUNCATED AT 250 WORDS)
Arch
Mal
Coeur Vaiss 1985 Jun
PMID:[Evaluation of left ventricular mass by M-mode and bidimensional echocardiography]. 293 Oct 58
Sixty four children with isolated congenital aortic stenosis (39 valvular, 16 fixed subvalvular, 4 supravalvular and 5 multiple) were operated at a mean age of 11,5 years. Valve repair was possible in all but three patients who had to undergo valvular replacement. Myotomy was associated in 18 cases (28 p. 100). The mean systolic pressure gradient was 79,9 mmHg (+/- 17,8); there was associated aortic regurgitation in 21 patients but this was minimal except in one case. Twenty children (31 p. 100) had symptoms on effort and the basal ECG showed ST-T wave changes in the left precordial leads in 30 cases (47 p. 100). Several preoperative exercise ECGs were performed in 29 patients without ST-T changes on the resting ECG. The exercise ECG was positive in 15 patients, providing one of the arguments for surgery; a poor blood pressure response to exercise was observed in 12 patients with a negative test. Out of the 28 patients with a positive preoperative exercise ECG, 7 (25 p. 100) went on having a positive result after surgery (p less than 0,05). The maximal heart rate was not significantly higher after surgery but the total work was significantly greater (p less than 0,01) and the increase in systolic blood pressure was even more significant (p less than 0,001). Out of 14 patients undergoing repeat catheterisation for a continuing positive exercise ECG or for ST-T wave changes on the resting ECG, there were 6 residual severe stenoses, 3 severe aortic regurgitations, 3 hypertrophic cardiomyopathies which were obstructive in 2 cases. The exercise ECG is a means of appreciating the consequences of the stenosis which are the cause of the complications (myocardial ischemia and poor blood pressure adaptation). This justifies its use in assessing the surgical indications and for the follow-up of the surgical result. A persistantly positive exercise ECG and continuing ST-T wave changes on the resting ECG are signs of a poor surgical result and hemodynamic revaluation should be considered; besides severe postoperative aortic regurgitation, residual or recurrent stenosis and, above all,
asymmetric septal hypertrophy
, obstructive or not, are the main causes of poor postoperative results.
Arch
Mal
Coeur Vaiss 1983 Jul
PMID:[Importance of the exercise test in the follow-up of surgically treated congenital aortic stenoses]. 641 51
The aortic subvalvular region is difficult to approach. The results after resection through a pure transaortic approach are often unsatisfactory. An aorto-septal approach derived from the Konno-Rastan aortoventriculoplasty was experimented in animals. This technique involves opening the ascending aorta and the pulmonary infundibulum, section of the aortic annulus at the left anterior commissure and incising the muscular interventricular septum. The results of this aorto-septal approach show: - that the whole left ventricular ejection tract can be exposed; - that the incision can be closed without damage to the heart, i.e. creation of atrioventricular block, and with reconstruction of an intact interventricular septum and a normally functioning aortic valve. This approach could therefore be used for the treatment of diffuse subvalvular aortic stenosis: - subaortic fibromuscular tunnel without hypoplasia of the aortic ring (one personal case has already been reported); - severe forms of hypertrophic obstructive cardiomyopathy with
asymmetric septal hypertrophy
.
Arch
Mal
Coeur Vaiss 1984 Mar
PMID:[Surgical treatment of aortic subvalvular obstruction. Experimental study of a new approach]. 642 16
The association of
asymmetric septal hypertrophy
and Fallot's tetralogy is very rare. The authors describe a case in an infant documented by angiography and 2D echocardiography. The prevalence of complex forms of Fallot's tetralogy and the diagnostic and therapeutic problems which they pose, are discussed.
Arch
Mal
Coeur Vaiss 1984 May
PMID:[A rare pathological association: Fallot's tetralogy and asymmetric septal hypertrophy]. 642 56
The interventricular septum was studied by biventricular angiography in 52 patients divided into 4 groups: the first group consisted of 14 normal subjects; the second of 10 patients with hypertension (9 cases) or aortic stenosis (1 case); the third, of 19 patients with echocardiographic
asymmetric septal hypertrophy
, and the fourth, of 9 cases of cardiomyopathy with dilatation. The following parameters were measured: septal thickness at 4 different points and mean septal thickness, the height (long axis) and surface of the septum in diastole and systole. The percentage variation was calculated. There were no significant differences between Group I and II; there was a significant difference (p less than 0,01) in the variations of septal thickness of the upper segments between Group I and III. This difference remained significant (p less than 0,05) for the variations of mean thickness between Group I (-38%) and Group III (-18%). There was also a significant difference (p less than 0,05) in the variation of height between Group I (23%) and Group IV (9%). None of the variations of septal surface reached the threshold of statistical significance between the four groups. Biventricular angiography can therefore demonstrate certain abnormalities of septal motion. In
asymmetric septal hypertrophy
, the variations in thickness are significantly less pronounced than in normal subjects but the motion in the longitudinal axis does not differ significantly. In cardiomyopathy with dilatation, however, the variation in septal height is the most affected parameter.
Arch
Mal
Coeur Vaiss 1984 Jun
PMID:[Angiographic study of the dynamics of the interventricular septum]. 643 30