Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0184567 (acute pain)
 3,962 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Sep 253
opioid receptor 84
COX-2 53
Mol 51
cyclooxygenase-2 42
She 38
substance P 36
cyclooxygenase 35
TRPV1 34
MRI 33
hemoglobin 28
PCA 24
GABA 24
NMDA receptor 22
cytokine 22
COX-1 22
calcitonin 22
TRPA1 18
TNF 17
bradykinin 16
beta-endorphin 16
ATP 16
transient receptor potential vanilloid 1 15
cannabinoid receptor 15
ASA 13
reserved 13
CB1 12
nitric oxide synthase 11
axonal 11
CFA 11
calcium channel 11
COX 10
APS 10
arrestin 9
IL-6 9
mu opioid receptor 9
sodium channel 9
TLR4 9
phosphodiesterase 9
ankylosing spondylitis 9
OFQ 8
CSF 8
P2X 8
collagen 8
ankyrin 1 8
corticotropin-releasing factor 8
SNS 8
lipopolysaccharide 8
brain-derived neurotrophic factor 8
neurotensin 8
p38 7
IL-1 7
CB2 7
SII 7
delta opioid receptor 7
rat) 7
insulin 7
Pol 7
IL-10 7
DRG 7
cyclooxygenase 2 7
proenkephalin 6
ERK 6
c-fos 6
ANOVA 6
P2X4 6
TRPM8 6
5-hydroxytryptamine 6
NNT 6
interleukin-6 6
Nav1.7 6
tumor necrosis factor 6
somatostatin 6
olfactory 6
interferon 6
short form 5
gut 5
C-reactive protein 5
B12 5
cage 5
inducible nitric oxide synthase 5
Hip 5
HBB 5
NHS 5
WIN 5
CD4 5
adenosine receptor 5
L-type calcium channel 5
LPS 5
nicotinic acetylcholine receptor 5
anonymous 5
proton pump 5
chemokine 5
TRP 5
GHRP 4
ghrelin 4
T12 4
FPS 4
CD8 4
APA 4
KOR 4
asymmetrical 4
orexin 4
COX2 4
prodynorphin 4
aspartate aminotransferase 4
CCL2 4
Rec 4
metabotropic glutamate receptor 4
NK1 4
parvalbumin 4
ARC 4
nerve growth factor 4
polypeptide 4
Mal 4
P2X3 4
KCC2 4
ACS 4
urocortin 4
glial fibrillary acidic protein 4
Itch 4
mTOR 4
ionotropic 4
membrane-bound 4
kappa opioid receptor 4
Mil 4
dilute 4
mast cell 4
GPI 3
muscarinic receptor 3
chronic renal failure 3
COX1 3
dynorphin 3
creatine kinase 3
Ghrelin 3
Gen 3
vasopressin 3
AMP 3
mouse) 3
mitogen-activated protein 3
glucagon 3
MAPK 3
oxytocin 3
ionized calcium-binding adapter molecule 3
Met 3
fatty acid amide hydrolase 3
methyltransferase 3
CGRP 3
adenylyl cyclase 3
microsomal 3
TCS 3
AKT 3
lymphoid 3
MIF 3
haptoglobin 3
NTR 3
Mot 3
HEK 3
white cell 3
calcineurin 3
more...
Disease
chronic pain 973
cancer 184
depression 173
sickle cell disease 113
cold 112
osteoarthritis 91
addiction 84
herpes zoster 76
postherpetic neuralgia 70
arthritis 69
rheumatoid arthritis 61
tumor 55
migraine 48
pruritus 45
rash 41
osteoporosis 33
ischemia 32
stroke 32
fibromyalgia 29
diabetes 27
Frey 26
hypertension 25
PCA 24
varicella 23
peripheral neuropathy 23
neuropathy 21
cognitive impairment 21
Best 19
hernia 18
breast cancer 17
multiple sclerosis 16
fits 15
acute chest syndrome 15
emotional distress 14
trigeminal neuralgia 14
physical dependence 14
renal failure 13
gout 12
deep vein thrombosis 12
confusion 12
NAME 12
diabetic neuropathy 12
delirium 12
phantom limb pain 12
appendicitis 11
acute appendicitis 11
pneumonia 11
anemia 11
posttraumatic stress disorder 11
PGA 11
aggression 11
asthma 10
obesity 10
HIV 10
drug addiction 10
haemophilia 10
tendinitis 10
myocardial infarction 9
gallstones 9
synovitis 9
West 9
ankylosing spondylitis 9
substance abuse 9
Alzheimer's disease 9
carcinoma 9
mental illness 9
Infection 9
infectious diseases 8
Toxic epidermal necrolysis 8
scrotum 8
psychological distress 8
inguinal hernia 8
genetic disorder 8
psychological stress 8
thalassemia 8
arthropathy 8
rheumatism 8
acute cholecystitis 7
radiculopathy 7
compartment syndrome 7
AIDS 7
ureter 7
emotional stress 7
metastases 7
suicide 7
anxiety disorders 7
sepsis 7
hydronephrosis 7
epilepsy 7
dementia 7
Haemophilia 7
infertility 7
peritonitis 7
heart failure 7
irritable bowel syndrome 6
bowel obstruction 6
tension headache 6
inflammatory bowel disease 6
pancreatitis 6
immunodeficiency 6
pulmonary embolism 6
renal impairment 6
cholecystitis 6
liver disease 6
sleep disturbances 6
monoarthritis 6
hemolytic anemia 6
Thoracic 6
endometriosis 6
cardiovascular disease 6
periarthritis 6
regional pain syndrome 6
osteomyelitis 6
renal disease 6
abortion 6
cornea 6
psychogenic pain 6
chronic renal failure 6
Anterior 5
dysphoria 5
neuroticism 5
Opiates 5
neuritis 5
sickle cell crisis 5
myocardial ischemia 5
alcohol abuse 5
diverticulitis 5
incontinence 5
drug abuse 5
septic arthritis 5
mononeuropathy 5
fasciitis 5
pulmonary hypertension 5
sepsis 5
peptic ulcer 5
cancer recurrence 5
HBB 5
HBB 5
celiac disease 5
HBB 5
bursitis 5
ileus 5
NHS 5
ectopic pregnancy 5
bone metastases 5
gangrene 5
reflex sympathetic dystrophy 5
Cannabis 5
Crohn's disease 5
trismus 5
Gaucher disease 5
proteinuria 4
rare disease 4
head and neck cancer 4
vasculitis 4
substance use disorders 4
influenza 4
Still 4
optic neuritis 4
urinary tract infection 4
more...
Symptom
acute pain 3962
pain 2978
analgesia 727
anesthesia 254
headache 105
cancer pain 92
nausea 71
low back pain 69
back pain 64
vomiting 63
Postoperative pain 46
dental pain 44
discomfort 41
abdominal pain 41
discomfort 38
nausea and vomiting 36
constipation 32
myalgia 29
orofacial pain 29
Neuropathic pain 27
weakness 24
distraction 24
dizziness 23
fatigue 22
facial pain 19
breakthrough pain 18
neuralgia 18
arthralgia 18
sleepiness 16
erythema 15
cough 15
chronic back pain 14
seizures 14
acute abdominal pain 13
neck pain 13
dyspnea 13
diarrhea 12
chest pain 12
paresthesia 11
spasm 10
PAIN 10
collapse 10
pelvic pain 10
renal colic 10
acute stress 10
agitation 9
knee pain 9
bone pain 9
functional recovery 8
acute low back pain 8
numbness 8
shoulder pain 8
angina 7
acute abdomen 7
hypothermia 7
colic 6
Severe pain 6
sciatica 6
hip pain 6
Sedation 6
insomnia 5
tingling 5
Inflammatory pain 5
limb pain 5
Grimace 5
splenomegaly 5
pallor 4
paresis 4
stigma 4
tremor 4
Postoperative nausea and vomiting 4
leg pain 4
Ill 3
enuresis 3
spasticity 3
anorexia 3
ataxia 3
sore throat 3
stump pain 3
overweight 3
dry skin 2
lethargy 2
respiratory distress 2
Wind 2
heartburn 2
flank pain 2
syncope 2
Pain symptoms 2
ankle pain 2
Labor pain 2
myoclonus 2
muscle rigidity 2
elbow pain 2
hypocapnia 2
hepatomegaly 2
catatonia 2
muscle cramps 2
apathy 2
Pain at rest 2
epigastric pain 2
tense 2
incoordination 2
cyanosis 2
postpartum pain 2
abdominal discomfort 2
jaw pain 2
shortness of breath 2
Central pain 2
hunger 2
loss of taste 1
alexithymia 1
right upper quadrant pain 1
Activity intolerance 1
excessive sweating 1
dysesthesia 1
body pain 1
memory loss 1
Cutaneous hyperalgesia 1
right lower quadrant pain 1
scaly skin 1
loss of balance 1
flushing 1
belching 1
musculoskeletal chest pain 1
blurred vision 1
swollen scrotum 1
tinnitus 1
glossodynia 1
Idiopathic scrotal edema 1
hematocolpos 1
hemoptysis 1
tachypnea 1
Thoracic pain 1
skin pain 1
chest tightness 1
Procedural pain 1
joint stiffness 1
twitching 1
pneumaturia 1
dry eye 1
athetosis 1
Neurogenic pain 1
vertigo 1
livedo 1
Postoperative nausea 1
Sympathetically maintained pain 1
wheezing 1
lightheadedness 1
hemiplegia 1
chills 1
thigh pain 1
heel pain 1
ENT 1
night sweats 1
orthopnea 1
paraparesis 1
Welt 1
exhaustion 1
Signs and Symptoms 1
stomach pain 1
more...
Drug
Tapentadol 20
Dermatol 16
Ketorolac 15
Fentanyl 14
Lumiracoxib 13
Cardiovasc 9
Gabapentin 8
CSF 8
caffeine 7
Ketorolac tromethamine 7
lysine 6
Bupivacaine 6
Parecoxib 5
nitroglycerin 5
Monit 5
9-THC 4
Celebrex 4
Pregabalin 4
GHRP 4
Valdecoxib 4
Emodin 3
ENT 3
Clonidine 3
Vioxx 3
Award 2
Indomethacin 2
IL-1ra 2
Capsicum 2
Domperidone 2
Etodolac 2
Duloxetine 2
Mobic 2
Nimesulide 2
PCP 2
EE2 2
Codeine 2
Codeine 2
Indoprofen 2
Percocet 2
ICI 2
ROC 2
Heme 2
Acyclovir 2
Lornoxicam 2
Triad 2
MgSO4 2
lactose 2
FCV 2
VCR 1
Meclomen 1
Sodium alginate 1
Nephron 1
Zoledronic acid 1
BH4 1
pyridoxal phosphate 1
Rizatriptan 1
Sorafenib 1
BTC 1
PFA 1
Camp 1
BoNT/A 1
Proglumide 1
BOTOX 1
APM 1
MAP 1
L-tyrosine 1
DPA 1
DEX 1
OTC 1
Asthma 1
Vinpocetine 1
Propofol 1
Horizon 1
Tenoxicam 1
Maalox 1
Zomepirac sodium 1
Reboxetine 1
Ibandronate 1
Chymopapain 1
Cytidine 1
OTC 1
CAM 1
Gastro 1
Zoledronic acid 1
Pirprofen 1
Tiaprofenic acid 1
Diclofenac potassium 1
Oxycon 1
Rasagiline 1
Effexor 1
Ergometrine 1
Escitalopram 1
Portal 1
Arthrex 1
IFN-gamma 1
Salmon calcitonin 1
Hyaluronidase 1
SNL 1
Spectrum 1
Glycerol 1
THA 1
Atropine 1
Cimetidine 1
Cimetidine 1
Vivitrol 1
Gel 1
TMS 1
AMC 1
Medetomidine 1
Hyaluronidase 1
Enoximone 1
Prednisone 1
ascorbate 1
p75 1
Check 1
vitamin E 1
Oxaliplatin 1
Elmiron 1
Alvimopan 1
Keppra 1
Levocabastine 1
Meconium 1
Atipamezole 1
Ketalar 1
Nefopam hydrochloride 1
Zileuton 1
Nabumetone 1
Ginseng 1
ROS 1
Butorphanol 1
Arsenic trioxide 1
Estrogens 1
CTX 1
Dipyrone 1
Ketalar 1
Enzyme
protein kinase 17
protein kinase C 15
ERK 11
mitogen-activated protein kinase 9
phosphodiesterase 9
focal adhesion kinase 8
guanylate cyclase 5
creatine kinase 5
FPS 4
aspartate aminotransferase 4
phospholipase C 4
ACS 4
heme oxygenase 3
catalase 3
adenylate cyclase 3
peroxidase 3
PKG 3
NO synthase 3
lactate dehydrogenase 3
calcineurin 3
AMP-activated protein kinase 3
monoamine oxidase 2
botulinum neurotoxin 2
tyrosine hydroxylase 2
lipase 2
AMPK 2
glutaminase 2
lipoxygenase 2
caspase-3 2
transcriptase 2
beta-galactosidase 2
superoxide dismutase 2
thrombin 2
RNA polymerase 2
AMPK 2
MEK 2
PCP 2
CYP3A4 2
tryptophan hydroxylase 2
ATPase 2
tissue plasminogen activator 1
NADPH-diaphorase 1
aldehyde dehydrogenase 1
urokinase-type plasminogen activator 1
CPT 1
prostate-specific membrane antigen 1
prostate-specific antigen 1
ALDH 1
hyaluronidase 1
factor C 1
aldolase 1
D-aspartate oxidase 1
histidine decarboxylase 1
hyaluronidase 1
soluble epoxide hydrolase 1
GRK2 1
MAP 1
GD3 synthase 1
alanine aminotransferase 1
alkaline phosphatase 1
urease 1
IOR 1
aldehyde dehydrogenase 1
GSK 1
aldehyde dehydrogenase 1
CD10 1
renin 1
CPN 1
dopamine beta-hydroxylase 1
SOR 1
chymotrypsin 1
PRE 1
MDP 1
caspase-1 1
luciferase 1
ornithine transcarbamylase 1
cathepsin S 1
transpeptidase 1
GRK5 1
SOR 1
TSA 1
P-glycoprotein 1
urease 1
alpha-galactosidase 1
ACE 1
catechol O-methyltransferase 1
trypsin 1
aldehyde dehydrogenase 1
CPT 1
CPS 1
lactase 1
CPT 1
PST 1
thromboplastin 1
DNA methyltransferase 1
PTA 1
aldehyde dehydrogenase 1
SRR 1
acid phosphatase 1
monoacylglycerol lipase 1
Compound
Clin 340
Dec 271
calcium 65
oxygen 60
sodium 59
water 46
glutamate 42
Morphine 40
APAP 32
acetic acid 29
NMDA 27
GABA 24
nitric oxide 24
GABA 24
potassium 24
Ketamine 21
Tramadol 21
ASA 19
arginine 17
TNF 17
ATP 16
noradrenaline 16
5-HT 15
Ketorolac 15
glucose 15
Ibuprofen 14
Celecoxib 14
cysteine 12
tyrosine 12
lysine 12
ethanol 11
DNA 11
Rofecoxib 11
Optimal 10
Naloxone 10
APS 10
COX 10
His 10
CO2 9
cGMP 9
methionine 9
Meloxicam 9
PGE2 9
Etoricoxib 9
iron 9
sulfate 8
Buprenorphine 8
HCl 8
caffeine 8
leucine 8
phosphate 8
PGE 8
Methadone 8
salt 7
Lidocaine 7
Paclitaxel 7
Gly 7
Oxycodone 7
6-12 7
Bupivacaine 6
AMPA 6
Diclofenac 6
Capsaicin 6
nitrogen 6
DAMGO 6
Meperidine 6
urea 6
cAMP 6
Glutamate 6
formaldehyde 6
NH2 6
Phe 6
glycerol 5
Neuronal 5
phenol 5
gamma-aminobutyric acid 5
PEG 5
Cardiol 5
HBB 5
propionic acid 5
tryptophan 5
Substance P 5
propionic acid 5
A 3 5
aspartic acid 5
Cortisol 5
Hemoglobin 5
hydroxide 5
acetate 5
glutamine 4
Bradykinin 4
Remifentanil 4
NOP 4
Ketoprofen 4
AMP 4
GMP 4
ACS 4
A 42 4
AEA 4
Mg2+ 4
benzamide 4
Hydromorphone 4
creatinine 4
ACS 4
Hydroxyurea 4
DMSO 4
vitamin D 4
AEA 4
serine 3
alanine 3
PEG 3
Ile 3
Melatonin 3
Nalbuphine 3
Carprofen 3
zinc 3
titanium 3
barium 3
pyridine 3
DSM 3
Dextromethorphan 3
manganese 3
Acyclovir 3
Amitriptyline 3
Pentazocine 3
Cereb 3
methanol 3
acetone 3
Carrageenan 3
TTS 3
Pentazocine 3
thymol 3
Asp 2
carbonate 2
glutamic acid 2
Adenosine 2
Kyotorphin 2
cyclohexanol 2
galactose 2
aldehyde 2
dichloromethane 2
Suprofen 2
hexane 2
FAP 2
Metformin 2
Resiniferatoxin 2
FAP 2
cyclohexanol 2
ICI 2
Sodium 2
piperidine 2
N2O 2
Metformin 2
Indomethacin 2
ethyl acetate 2
cobalt 2
butyric acid 2
tin 2
NBQX 2
PAG 2
more...