Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0184567 (acute pain)
 3,962 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

We report on a 29-year old woman, gravida 1, para 0, who complained, after 6 weeks of amenorrhoea, of vaginal bleeding and acute pain in the lower left abdomen. A non-ruptured left ampullary tubal pregnancy was recognised at diagnostic laparoscopy and removed by tube-preserving surgery. Subsequently, serum human chorionic gonadotropin (hCG) was quantified every two days; a rising hCG concentration confirmed a persistent ectopic gestation in the patient. 12 days after conservative laparoscopic surgery, treatment with methotrexate (1 mg/kg intramuscularly a day) during 4 days was initiated. After another brief rise, the hCG concentration dropped continuously down and was no longer detectable after 2 months.
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PMID:[Successful drug therapy of persistent ectopic pregnancy after tube-saving operation]. 792 78

Choriocarcinoma is a malignant trophoblastic cancer, the incidence of primary choriocarcinoma (PCC) of the gastrointestinal tract (GIT) being extremely rare, with only 14 cases being reported in worldwide literature. Here we present an extremely rare case of PCCof the appendix in a 32-year-old male who presented with acute pain abdomen. Histopathological examination revealed PCC of the appendix. Examination of the testis was unremarkable. Further investigations revealed a very high serum beta-human chorionic gonadotropin (b-HCG) titer with a normal carcinoembryonic antigen (CEA). Radiological imaging showed multiple areas of liver metastasis. Chemotherapy-based treatment with bleomycin, etoposide, and cisplatin (BEP) regime was advised, however the patient failed to follow-up for further management.
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PMID:Primary choriocarcinoma of appendix mimicking acute appendicitis. 2688 17