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Target Concepts:
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Query: UMLS:C0184567 (
acute pain
)
3,962
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Endothelin-1
(
ET-1
) is a known algogen that causes
acute pain
and sensitization in humans and spontaneous nociceptive behaviors when injected into the periphery in rats. This study sought to examine the effect of
ET-1
exposure in the neonatal period on subsequent contralateral capsaicin-induced secondary mechanical hyperalgesia.
ET-1
or saline was injected into the left plantar hindpaw on postnatal day 7 (P7). On postnatal day 11 (P11), capsaicin cream or control lotion was applied to the right dorsum hind paw and mechanical paw withdrawal thresholds were measured in the plantar hind paw. In saline control males, P11 administration of capsaicin produced a secondary mechanical hyperalgesia that was still present at 2h. Neonatal priming with
ET-1
did not alter the magnitude or the duration of secondary mechanical hyperalgesia in males. In contrast, in control females, P11 administration of capsaicin produced less than 40 min of mechanical hyperalgesia. Neonatal priming with
ET-1
prolonged the duration of secondary mechanical hyperalgesia in females. Priming with
ET-1
on P7 led to a significant increase in capsaicin-induced Fos expression in the dorsal horn of the spinal cord in both males and females compared to controls (p<0.001). These findings further suggest that pain in early life may alter future responses to painful stimuli at both the behavioral and neuronal level.
...
PMID:Endothelin-1-induced priming to capsaicin in young animals. 2467 71
Endothelin-1
(
ET-1
) is a known algogen that causes
acute pain
and sensitization in humans and spontaneous nociceptive behaviors when injected into the periphery in rats, and is elevated during vaso-occlusive episodes (VOEs) in sickle cell disease (SCD) patients. Previously, our lab has shown that a priming dose of
ET-1
produces sensitization to capsaicin-induce secondary hyperalgesia. The goal of this study was to determine if the sensitization induced by
ET-1
priming is occurring at the level of the primary afferent neuron. Calcium imaging in cultured dorsal root ganglion (DRG) neurons was utilized to examine the effects of
ET-1
on primary afferent neurons.
ET-1
induces [Ca(2+)]i transients in unprimed cells.
ET-1
induced [Ca(2+)]i transients are attenuated by priming with
ET-1
. This priming effect occurs whether the priming dose is given 0-4 days prior to the challenge dose. Similarly,
ET-1
priming decreases capsaicin-induced [Ca(2+)]i transients. At the level of the primary afferent neuron,
ET-1
priming has a desensitizing effect on challenge exposures to
ET-1
and capsaicin.
...
PMID:Endothelin-1 induced desensitization in primary afferent neurons. 2522 Jul 3
