Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0184567 (
acute pain
)
3,962
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
This study investigated whether (i) the 5:1 combination of standardized extracts of
Zingiber officinale
and
Acmella oleracea
is endowed with analgesic effects and (ii) the phospholipid-based formulation of
Zingiber officinale
and
Acmella oleracea
extracts (
ZAP
) potentiated the analgesic effects of the plain extract combination (PEC). To this end, rats were exposed to
acute pain
(Tail Flick test) and chronic, inflammatory pain [Von Frey monofilament test and Randall-Selitto paw pressure test in rats treated intraplantarily with complete Freund's adjuvant (CFA)]. The plain combination of
per se
ineffective doses of the two extracts produced analgesic effects in healthy rats.
ZAP
was more potent and effective than the corresponding doses of PEC.
ZAP
also produced analgesic effects in CFA-treated rats. Studies are now warranted to assess whether the analgesic properties of
ZAP
may generalize to humans.
...
PMID:Analgesic properties of a food grade lecithin delivery system of
Zingiber officinale
and
Acmella oleracea
standardized extracts in rats. 3165 Nov 94
