Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0184567 (acute pain)
 3,962 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Sickle cell syndrome (SCS) includes a group of congenital hemolytic anemias associated to the presence of hemoglobin S, which is characterized by acute pain episodes and progressive damage of different organs. Some patients with sickle cell syndrome have shown, when compared with healthy individuals, an increased risk of presenting stroke, pulmonary hypertension, avascular necrosis of joints, acute chest syndrome and pregnancy complications, associated to a hypercoagulable state induced by alterations in different components of hemostasis, such as changes that include activation of the endothelium, platelet activity, coagulation and fibrinolytic systems. This paper compiles hemostasis disorders, associated with thrombotic manifestations, reported until now in sickle cell syndrom. These patients have an increase in activation markers of the coagulation system, such as prothrombin fragment 1.2, thrombin-antithrombin complex, etc., depletion of natural anticoagulant proteins, abnormal activation of the fibrinolytic system and increased tissue factor expression. Similarly, abnormal expression of glycoproteins and increased adhesion and platelet aggregation have been reported. All these alterations produce a hypercoagulable state, which induces, among other things, the appearance of thrombotic complications. In view of the importance of controlling the different complications that can occur in patients with sickle cell syndrome, we recommend the implementation, in diagnosis and monitoring studies, of the evaluation of the different components of the hemostatic system, identifying alterations at an early stage and applying effective treatments to prevent thrombotic complications.
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PMID:[Hemostasis alterations in sickle cell syndrome]. 2497 33

Pregnancy is well-known risk factor for deep vein thrombosis (DVT), which usually occurs during the third trimester and in the left-sided lower extremity. We present a case of left subclavian and right femoral vein thrombosis in a pregnant woman with a gestational age of 10 weeks. A 39-year-old woman visited the emergency department complaining of acute pain and swelling of the left upper arm and right lower extremity. She showed swelling of the left upper arm and right lower extremity and a low antithrombin level of 40%. Ultrasound examination showed right femoral and left subclavian vein thrombosis. Her DVTs were treated with unfractionated heparin. Five months later, she received a cesarean delivery with intravenous unfractionated heparin and antithrombin replacement to prevent DVT, and she successfully gave birth. A genetic test for antithrombin deficiency confirmed hereditary antithrombin deficiency. DVT during pregnancy can occur in an upper extremity and at multiple sites. An undiagnosed coagulation disorder magnifies the risk of DVT in pregnant patients. We should examine all extremities for which there are complaints of pain and swelling with suspicion of DVT and consecutively search for an underlying coagulation disorder in pregnant patients with unusual clinical features of DVT. <Learning objective: Deep venous thrombosis (DVT) during pregnancy can occur in an upper extremity and at multiple sites. An undiagnosed coagulation disorder magnifies the risk of DVT in pregnant patients. We should examine all extremities for which there are complaints of pain and swelling with suspicion of DVT and consecutively search for an underlying coagulation disorder in pregnant patients with unusual clinical features of DVT.>.
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PMID:Left subclavian and right femoral vein thrombosis in a pregnant patient with antithrombin deficiency. 3027 35