Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0184567 (acute pain)
 3,962 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

When faced with subcutaneous calcifications the possibility of the Thibierge-Weissenbach syndrome, either in its initial stages or already evolutive, may be forgotten. In one typical case that was followed for 20 years, the calcifications had taken second place to the scleroderma and circulatory disorders that had rapidly dominated the picture : Raynaud's phenomenon, arteritis of the extremities with extremely acute pain that was lessened only by sympathetic infiltrations or intra-arterial injections.
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PMID:[Subcutaneous calcifications. A case of Thibierge-Weissenbach syndrome]. 122 40

Glomus tumors are rare, though not exceptional. They are considered by some authors as hyperplasia of a normal neuromyo-arterial glomus, by others as a benign tumoral proliferation. Most of them combine the three histological types initially described by Masson. i.e. solid, angiomatous and muco-hyaline. Subungual glomus tumors are more often seen in middle-aged subjects than in children. Although often belatedly diagnosed, they have characteristic symptoms, notably paroxysmal, acute pain provoked by cold or by minimal traumas: the Raynaud's phenomenon is inconstant and localized to the tip of the affected finger. When clinical and standard radiological examinations are normal, arteriography may be useful to confirm the diagnosis and locate the lesion. The main differential diagnoses before arteriography are post-traumatic neuroma and subungual melanoma. Surgical treatment is straightforward, but pain may recur post-operatively; it may be due to incomplete excision, development of a new tumor, presence of other tumors or cicatricial neuroma.
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PMID:[Subungual glomus tumor. Apropos of a case]. 298 96