Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0184567 (acute pain)
 3,962 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Major rim pathology is a precursor of osteoarthritis of the hip secondary to residual acetabular dysplasia. The symptoms are acute pain in the groin and impaired function; the anatomopathologic lesions consist in avulsions of the labrum from the bony rim, and separated bone fragments or "Os acetabuli", as well. A detailed radiographic, comparative inquiry to assess the preoperative morphology of 178 dysplastic hips which underwent a multiplanar periacetabular osteotomy was undertaken. The study showed that the 37 hips with a labral avulsion had a less pronounced anterior and lateral insufficiency of the acetabulum and a less pronounced lateral subluxation than dysplastic hips without these lesions. No specific radiologic features could be found in the 23 hips with bony fragments of the acetabular rim. The instability of the joint exerts abnormal stress on the acetabular rim which tends to tear it. This condition leads to rapid arthrotic degeneration of the hip; early diagnosis increases our ability to preserve the integrity of the joint through reliable reconstructive surgery.
 ...
PMID:Acetabular rim pathology secondary to congenital hip dysplasia in the adult. A radiographic study. 870 42

(1) The first-line drugs for mild to moderate pain are non opiate analgesics, namely paracetamol and nonsteroidal antiinflammatory drugs (NSAIDs). (2) Codeine, dextropropoxyphene and tramadol are weak opiates; they are often used with paracetamol in fixed-dose combinations, in order to reinforce the analgesic effect of paracetamol. (3) These analgesic combinations have only been evaluated in a few situations associated with chronic and acute pain. And the endpoints used in clinical trials are designed more to show statistically significant differences than clear clinical differences. (4) In acute pain, available meta-analyses confirm that the first-line drug is paracetamol, or, if necessary, ibuprofen, a NSAID. (5) The paracetamol + codeine combination slightly increases the analgesic effect of paracetamol, but causes more adverse effects. Combinations of paracetamol + dextropropoxyphene and paracetamol + tramadol are even less useful. (6) The few available clinical trials fail to demonstrate that combining paracetamol with a NSAID is any more effective than either drug given alone, while adverse effects are increased. (7) Paracetamol is also the first-line treatment for chronic non cancer pain, such as low back pain or pain due to osteoarthritis of the hip. NSAIDs have no advantages over paracetamol in these settings. We found no trials of paracetamol + NSAID combinations. Combinations of paracetamol and weak opiates have been inadequately studied in this situation, and are only second-line options.
 ...
PMID:Weak opiate analgesics: modest practical merits. 1505 24