Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0184567 (acute pain)
 3,962 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

At the end of her menstruation a 25 years old woman develops acute pain in her right lower and upper abdomen radiating into the right shoulder. There are pains during breathing, coughing, and changing of position, vomitus, and local signs of peritonitis in the right lower and upper abdomen, subicterus and leucocytosis. Gonococci in the cervical smear are demonstrated by Grams stain and by culture. Two days after treatment with 3,5 millions IU of penicillin G sodium and 500.000 IU procaine penicillin per day the complaints disappeared. The demonstrated signs and symptoms are characteristic for acute perihepatitis gonorrhoica which seems to occur more often as a complication of gonococcal adnexitis than is suspected. The symptoms are so typical that the diagnosis can be made also without confirmation by laparascopy.
 ...
PMID:[Clinical diagnosis of acute gonorrhic perihepatitis]. 65 2

This article discusses the etiology, epidemiology, diagnosis, and treatment of pelvic inflammatory disease (PID). PID, which affects at least 1 million women in the US each year, has serious consequences: about 15% of cases become sterile after 1 infection, 15% develop chronic pain requiring surgery, and the ectopic pregnancy rate among women who do become pregnant is 10 times that among women without infection. The goal is to prevent PID by identifying cervicitis and endometritis before salpingitis develops and by advocating contraceptive methods that will reduce attack rates. Also important are prompt, accurate diagnosis and effective therapy. Sexually transmitted organisms are responsible for 50-75% of acute primary spontaneous salpingitis. Epidemiologic factors influence the rate of cervicitis and the development of salpingitis from cervicitis. These factors include age, number of sexual partners, frequency of sexual intercourse, and OC use. OC users have 1/2-1/4 the expected rate of both gonococcal and chlamydial salpingitis. The tremendous range of clinical signs and symptoms makes the diagnosis of salpingitis difficult, implying a need for physical and laboratory determinations. It is suggested that laparoscopy be more widely used to diagnose acute pain. Adequate treatment includes both antibiotic administration and close follow up to assess the clinical response and antibiotic compliance.
 ...
PMID:Pelvic inflammatory disease. 1228 Jan 52

Some 250 million cases of sexually transmitted disease (STD) occur each year, and in some countries 1 or even 2 women in every 10 are infected with an STD. STDs are likely to reach an advanced stage before women notice them. The consequences of STDs are devastating, according to a report by the Population Information Program of the Johns Hopkins School of Public Health, and they include stillbirths, blinding eye infections in the newborn, chronic female abdominal pain, ectopic pregnancy, and infertility. There are social consequences for women such as divorce, and husbands may abandon infertile wives. Gonorrhea and chlamydia can cause both severe inflammation of the pelvis with acute pain and possible infertility. Pelvic inflammatory disease can permanently scar the fallopian tubes, increasing the risk of ectopic pregnancy, which can be fatal when the fallopian tube ruptures. Babies born to mothers with gonorrhea and chlamydia are likely to develop eye infections that may make them blind. Chlamydia infection in pregnant women may also cause premature rupture of the membranes, sepsis, and the death of premature neonate. Infection may spread to the lungs of newborns, leading to chlamydial pneumonia. Syphilis can cause spontaneous abortion, stillbirth, neonatal death, or congenital syphilis in the infant. Trichomoniasis and herpes can also be transmitted from mother to fetus. And infection with an STD increases the risk of infection with the human immunodeficiency virus (HIV). The World Health Organization (WHO) recommends that prenatal care should always include checks for STDs. A WHO Technical Working Group on Care of Mother and Baby has stressed the importance of detecting and treating STDs in pregnant women. The working group urged training of health workers to distinguish between STDs and other infections. The group, which met July 5-9, 1993, outlined health center strategies for prevention and treatment.
 ...
PMID:STDs infect 250 million a year. 1234

Neisseria gonorrhoeae is an uncommon present-day cause of septic arthritis. It is generally seen in the younger patient population and is often difficult to isolate in the lab. Blood cultures performed as routine work are usually negative, and when positive tend to be seen in the classic form of disseminated gonococcal infection. Here we report a case of acute septic monoarthritis, associated with N. gonorrhoea bacteraemia, in a 67-year-old male patient with multiple chronic comorbidities, who presented with acute pain and swelling at his left elbow, and no associated skin changes. Arthrocentesis findings were consistent with septic arthritis. Blood cultures drawn on admission grew N. gonorrhoeae. Synovial fluid culture was sterile but did exhibit Gram-negative cocci on Gram stain. The patient was started on IV antibiotics, and later underwent incision and drainage with subsequent improvement in symptoms. We thus present an unusual form of disseminated gonococcal infection in the setting of: epidemiology, physical presentation, as well as microbiologic findings. Although less common, DGI should be considered in the differential for septic join in the older adult population, and a sexual history should be obtained in all patients. This patient ultimately had an excellent outcome given his prompt presentation after symptom onset and immediate initiation of medical therapy.
 ...
PMID:Acute septic elbow monoarthritis with associated Neisseria gonorrhoeae bacteraemia: an uncommon presentation of an old disease. 3248 91