Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0178874 (tumor progression)
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Human Gene/Protein
mitochondrial ubiquitin ligase activator of NFKB 1 9.6
Prostate transmembrane protein, androgen induced 1 9.6
ankyrin repeat domain 52 9.6
SLC35C2 9.6
Transmembrane protein 170B 9.6
LOC150622 9.6
splicing factor 3B subunit 2 9.6
associated transcript 7 9.6
Gamma-glutamyltransferase 5 9.6
ATP8A1 protein 9.6
FAD-dependent oxidoreductase domain containing 1 9.6
FBXL8 9.6
CK2A2 9.6
Rh family, C glycoprotein 9.6
ZNF233 9.6
Ubiquitin carboxyl-terminal hydrolase 47 9.6
LAMB1 protein 9.6
ZNF365 protein 9.6
WD repeat and FYVE domain containing 2 9.6
NADH-ubiquinone oxidoreductase flavoprotein 3 9.6
ubiquitin protein ligase E3 component n-recognin 2 9.6
RUN and FYVE domain containing 1 9.6
QSCN6 9.6
RBP7 protein 9.6
chromosome 6 open reading frame 106 9.6
Diffuse panbronchiolitis critical region 1 9.6
EDIL3 protein 9.6
DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 9.6
SPC18 protein 9.6
ST6GALNAC4 9.6
TMEM78 9.6
PTRH1 9.6
DEFB105A 9.6
FLJ23594 9.6
zinc finger protein 207 9.6
DXS1179E 9.6
WNT10B protein 9.6
TMPRSS13 protein 9.6
N4BP2L1 9.6
abhydrolase domain containing 14B 9.6
PLA2G16 protein 9.6
MYL9 protein 9.6
RNA-binding motif protein 43 9.6
Protease, serine, 3 9.6
Ribonuclease/angiogenin inhibitor 9.6
SEC14L1 protein 9.6
son of sevenless homolog 2 9.6
ZNF813 9.6
AKAP12 protein 9.6
CHRDL2 9.6
Family with sequence similarity 129, member A 9.6
MS4A15 9.6
RRP1B 8.9
HSPC111 8.9
RNFT1 8.6
Werner helicase interacting protein 8.6
ORC4L 8.6
RNA binding motif protein 47 8.6
zinc finger protein 441 8.6
GTP binding protein 1 8.6
FLOT2 protein 8.6
zinc finger and BTB domain containing 2 8.6
MS4A8 8.6
DENN/MADD domain containing 2D 8.6
SIGMA1B 8.6
HNRNPCL1 8.6
2'-5'-oligoadenylate synthetase 3 8.6
ING2b 8.6
MRPL52 8.6
Chromobox homolog 7 8.6
CD82 molecule 8.6
SH3GL2 protein 8.6
Sjogren syndrome antigen B 8.6
MS4A6 8.6
ZNF454 8.6
CD49C 8.6
MIF4G domain containing 8.6
MRPL28 8.6
SLITRK4 8.6
FBXO46 8.6
more...
Disease
Canine oral papillomatosis 9.6
Intrapelvic lymph nodes 9.6
tumor progression 9.6
Secondary autoimmune haemolytic anaemia 8.6
Gastric Adenocarcinoma 8.6
ENO4 8.0
monosomy 1p 8.0
SCN3 8.0
Oligoastrocytoma 8.0
Oligoastrocytoma 8.0
Hepatic vein occlusion 8.0
cancer seeding 8.0
Extrahepatic bile duct carcinoma 8.0
localized resectable neuroblastoma 8.0
Ovarian adenocarcinoma 7.8
Necrotic tumor 7.7
stage A prostate cancer 7.6
malignant nevus 7.6
Disseminated carcinoma 7.6
DIN 2 7.3
Acquired dysfibrinogenemia 7.3
Adrenocortical Tumor 7.3
RMD1 7.3
PanIN-1A 7.0
Atypical meningioma 7.0
Tuberculous epididymitis 7.0
In situ cancer 7.0
lower urinary tract cancer 6.8
recurrent Wilms tumor 6.8
Urothelial carcinoma in situ 6.8
CCA2 6.8
Horn cancer 6.8
Raccoonpox 6.8
tumor initiation 6.8
type C thymoma 6.6
monosomy 7p 6.6
FHL4 6.6
ear cancer 6.6
Pleomorphic malignant fibrous histiocytoma 6.6
Trisomy 17 6.6
Scirrhous gastric carcinoma 6.6
tumor angiogenesis 6.5
dVIN 6.4
ovarian mixed germ cell tumor 6.4
Primary cutaneous marginal zone B-cell lymphoma 6.4
Pancreatic intraepithelial neoplasia (PanIN) 6.4
metastatic follicular thyroid cancer 6.4
PanIN-1B 6.4
cancer regression 6.4
Secretory meningioma 6.3
Intraepithelial Neoplasia 6.3
Progression of prostate cancer 6.3
Coombs negative hemolytic anemia 6.3
CACP 6.3
Colorectal adenocarcinoma 6.3
melanoma stage 6.3
cancer angiogenesis 6.2
Omental metastasis 6.1
DIPNECH 6.1
stage IIB cervical cancer 6.1
Periodontal infection 6.1
Squamous cell carcinoma of the oral cavity 6.1
EMT 6.0
malignant giant cell tumor of bone 6.0
internal lesion 6.0
unresectable gallbladder cancer 6.0
Chemical cystitis 6.0
neuroblastoma stage 6.0
Clonal evolution 6.0
STHE 5.9
ADLTE 5.9
Preleukemia 5.9
prostate cancer stage 5.9
tumor growth 5.9
PanIN-1 5.9
tumorigenesis 5.8
Prostate tumor 5.8
tumor vasculature 5.8
MRX34 5.8
Melanoma-associated retinopathy 5.8
more...
Symptom
Perianal pain 8.6
Tissue anoxia 7.3
painful erections 4.4
Reticulocytosis 4.0
Pain symptoms 3.8
cachexia 3.2
Scratch 3.0
generalized rash 2.4
bone pain 2.4
Fluctuation 2.4
No adverse effect 2.3
cancer pain 2.2
adipsia 2.1
Stiffness 2.0
starvation 1.9
leg edema 1.8
disturbed balance 1.8
exhaustion 1.6
prostatism 1.4
hyperemesis 1.4
splenomegaly 1.2
anorexia 1.2
nausea 1.1
prostration 1.1
Tenderness 1.1
asthenia 1.0
nausea and vomiting 1.0
mastalgia 1.0
intestinal bleeding 1.0
abdominal fullness 0.9
breakthrough pain 0.9
clubbing 0.8
loss of balance 0.8
stomach pain 0.6
skin damage 0.6
lightheadedness 0.6
abdominal cramps 0.6
hot flashes 0.6
swollen joints 0.5
vomiting 0.5
acidity 0.5
Postoperative pain 0.5
Anoxia 0.5
Gastrointestinal symptoms 0.4
facial pain 0.4
pleuritic chest pain 0.4
HSA 0.4
dysuria 0.3
hot flushes 0.3
rales 0.3
fasciculation 0.3
partial seizure 0.2
CSR 0.2
fatigue 0.1
chills 0.1
diarrhea 0.1
hyperoxia 0.1
consciousness disturbance -0.1
collapse -0.1
exertional dyspnea -0.1
abdominal discomfort -0.1
neuralgia -0.2
hip pain -0.2
oliguria -0.2
DNA marker -0.3
tinnitus -0.3
dysesthesia -0.3
dry skin -0.4
Ill -0.4
hemoptysis -0.4
numbness -0.4
abdominal pain -0.4
fever of unknown origin -0.4
shortness of breath -0.4
joint stiffness -0.4
flank pain -0.5
hepatosplenomegaly -0.5
urinary frequency -0.5
productive cough -0.5
dyspnea -0.6
more...
Drug
Tanomastat 9.6
Efipladib 7.6
Peretinoin 7.3
Masoprocol 7.0
Masoprocol 6.8
Propagermanium 6.6
Prinomastat 6.4
Batimastat 5.7
Batimastat 5.7
Gardenia fruit 5.4
Eulexin 5.4
Sunitinib malate 5.4
Parnate 5.4
Genasense 5.4
Thioproline 5.2
Ferric ammonium citrate 5.2
Tobi 5.2
Tanespimycin 5.1
Bindarit 5.1
Purvalanol 5.1
Temodal 5.1
Ferumoxides 5.0
uPA 4.9
Zotarolimus 4.9
Nexavar 4.9
Tykerb 4.8
Pegvisomant 4.8
Bevacizumab 4.8
Provenge 4.8
GEO 4.7
Pertuzumab 4.6
Zebularine 4.5
Tarceva 4.4
Marimastat 4.4
Cilengitide 4.4
Trabectedin 4.4
Vitamin-E 4.4
Sorafenib 4.3
Alimta 4.3
Amlexanox 4.1
Leukine 4.1
Wellferon 4.1
Rapamune 4.1
Vatalanib 4.1
Vandetanib 4.1
PNT 4.1
Terguride 4.1
Bosutinib 4.1
Cetuximab 4.0
Avandia 4.0
Venofer 4.0
Epoetin beta 4.0
Epalrestat 4.0
Erlotinib 4.0
Allegra 3.9
Allegra 3.9
Xeloda 3.9
Silodosin 3.9
Macugen 3.9
4-Hydroxytamoxifen 3.8
Hyaluronidase 3.8
Urokinase 3.8
Bexarotene 3.8
Everolimus 3.8
Fulvestrant 3.7
Pirfenidone 3.7
Estracyt 3.7
Gefitinib 3.7
Arava 3.7
NVP 3.7
ETS 3.7
Celebrex 3.7
Gemzar 3.6
Docetaxel 3.6
Nafamostat mesilate 3.6
R1881 3.6
Estracyt 3.6
Hyaluronidase 3.6
Gliadel 3.6
Imatinib 3.6
more...
Enzyme
kallikrein 14 7.8
matrilysin-2 7.3
stromelysin-3 7.1
alpha1,4-N-acetylglucosaminyltransferase 6.8
kallikrein 10 6.8
GalNAc4S-6ST 6.5
hepsin 6.4
hepsin 6.4
N-acetylglucosaminyltransferase V 6.4
matriptase 6.2
thioether S-methyltransferase 6.1
matriptase 6.1
inositol polyphosphate 4-phosphatase 6.0
carboxypeptidase 1 6.0
cathepsin O 6.0
lysophospholipase D 5.9
N-acetylglucosaminyltransferase III 5.8
cathepsin X 5.7
tRNA isopentenyltransferase 5.5
glutaminase II 5.5
EC 5.3.99.2 5.5
matrix metalloproteinase 10 5.5
Cypridina luciferase 5.4
cancer procoagulant 5.4
collagenase 3 5.2
STK4 5.2
chondroitin 4-sulfotransferase 5.1
glycerophosphocholine phosphodiesterase 5.0
phosphatidylinositol-4,5-bisphosphate 3-kinase 5.0
lysyl oxidase 4.9
acylglycerol kinase 4.9
ADP-dependent glucokinase 4.9
matrix metalloproteinase 2 4.9
ceramide kinase 4.8
matrix metalloproteinase 14 4.7
prostasin 4.7
ALDH 4.7
tubulin-tyrosine ligase 4.7
15-hydroxyprostaglandin dehydrogenase 4.6
MMP 4.6
legumain 4.6
HK2 4.6
GGTase-I 4.5
macrophage elastase 4.4
lysine acetyltransferase 4.4
N-acetylglucosaminyltransferase 4.4
MMP-3 4.4
matrix metalloproteinase 9 4.4
nepenthesin 4.4
TACE 4.4
inositol 3-kinase 4.3
histone demethylase 4.3
acyloxyacyl hydrolase 4.2
tubulin carboxypeptidase 4.2
urokinase-type plasminogen activator 4.2
phosphatidylethanolamine N-methyltransferase 4.1
O-GlcNAc transferase 4.1
polypeptide N-acetylgalactosaminyltransferase 4.1
nicotinamide phosphoribosyltransferase 4.1
ERK 4.1
nicotinamide N-methyltransferase 4.1
eEF2 kinase 4.0
coagulation factor VIIa 4.0
cathepsin B 4.0
focal adhesion kinase 3.9
TUT 3.9
proprotein convertase 3.9
interstitial collagenase 3.9
KLK13 3.9
sarcosine dehydrogenase 3.8
phosphoinositide 3-kinase 3.8
RGP 3.8
sialyltransferase 3.8
alpha-methylacyl-CoA racemase 3.8
thymidine phosphorylase 3.8
sialyltransferase 3.7
sialyltransferase 3.7
MEK 3.7
luciferase 3.7
glucosylceramide synthase 3.7
more...
Compound
sulfuric acid compound with 9.6
sulfuric acid compound with 9.6
sulfuric acid compound with 9.6
2,4-diimino-1-methyl-1,3,5-triazepan-6-one 9.6
Aluminum ammonium sulfate 8.6
Avenanthramide A 8.6
Bilobol 8.0
Acetophenone oxime 7.6
Diethylstilbestrol diphosphate 7.6
C4H4N2O2 7.3
C4H4N2O2 7.0
Bromopyruvic acid 7.0
Pseurotin A 7.0
Vernolide 7.0
Galloflavin 7.0
5-Methoxytryptophan 7.0
K acid 7.0
nonanamide 6.8
5H-benzo[a]phenothiazine 6.8
N-ethylbenzamide 6.6
1-pyrrolidinecarbodithioic acid 6.6
4-pyrimidinol 6.6
hexaric acid 6.6
Convallatoxin 6.4
2,5-dimethoxybenzaldehyde 6.4
12H-benzo[a]phenothiazine 6.4
Propagermanium 6.4
o-Nitroanisole 6.4
Pyrvinium 6.4
Myrtenal 6.3
5-phenylisoxazole 6.3
2,5-dimethoxybenzaldehyde 6.3
2-hydroxy-5-methoxybenzaldehyde 6.3
Myrtenal 6.3
Triptonide 6.1
4-phenyl-3-butenoic acid 6.1
Bromoacetylcholine 6.1
Chebulagic acid 6.0
iodoacetonitrile 6.0
Chebulagic acid 6.0
Dicentrine 6.0
Pectolinarigenin 5.9
2,4-pyrimidinediamine 5.9
BVE 5.9
2-hydroxy-5-methoxybenzaldehyde 5.9
Polylactosamine 5.8
Poly-N-acetyllactosamine 5.8
Eupatorin 5.8
LLY 5.8
PDAP 5.7
cyclopentadecanone 5.7
Digitoxigenin 5.7
2-Nitroimidazole 5.6
Ammonium pyrrolidine dithiocarbamate 5.6
[6]-Shogaol 5.5
Sialyl Lewis a 5.5
EOC 5.5
Ver A 5.4
Granulin 5.4
27-Hydroxycholesterol 5.4
Oleandrin 5.4
Benzophenone-1 5.4
alpha-ketoglutaramate 5.4
TNM 5.3
Chebulinic acid 5.3
Agaritine 5.3
D-ribose-1-phosphate 5.3
2-Hydroxyglutarate 5.3
Vimentin 5.3
SLEX 5.2
Ailanthone 5.2
Azoxymethane 5.2
NIX 5.2
2-furylmethyl 5.1
Baccatin III 5.1
Baccatin III 5.1
Baccatin III 5.1
Procarbazine 5.1
NEU 5.1
Benzyl isothiocyanate 5.1
more...