Gene/Protein Disease Symptom Drug Enzyme Compound
Pivot Concepts:   Target Concepts:
Query: UMLS:C0178874 (tumor progression)
 40,807 document(s) hit in 31,850,051 MEDLINE articles (0.03 seconds) .

Concepts found in the documents ranked by [ Frequency | Pointwise Mutual Information | Symmetric Conditional Probability ] .
Human Gene/Protein
Mol 3394
Sep 2359
p53 2141
E-cadherin 1090
cytokine 1025
vascular endothelial growth factor 929
AKT 804
cage 771
catenin 752
PI3K 689
epidermal growth factor receptor 641
collagen 627
ERK 595
tyrosine kinase 537
mTOR 531
matrix metalloproteinase 526
VEGF 525
MAPK 501
CD8 500
histone 474
CD44 467
estrogen receptor 447
p21 434
vimentin 432
IL-6 431
EGFR 428
cyclin D1 425
chemokine 422
STAT3 413
TNM 404
MMP-9 364
ERK1 358
Bcl-2 358
CD4 354
HER2 350
fibronectin 342
Ki-67 342
MMP-2 328
osteosarcoma 306
PTEN 304
glycoprotein 300
caspase-3 295
IFN 295
IL-8 289
TNF 285
p38 279
N-cadherin 278
ras 269
c-Myc 267
lymphoid 267
receptor tyrosine kinase 266
beta-catenin 266
ATP 265
epidermal growth factor 262
Rho 262
androgen receptor 254
tumor necrosis factor 253
insulin 250
UTR 247
ubiquitin 244
EMT 243
BRAF 242
nodal 238
MEK 232
hepatocyte growth factor 230
p16 230
EGF 230
IL-10 229
TGF-beta 226
interferon 224
MRI 221
urokinase-type plasminogen activator 220
CXCR4 216
endoplasmic reticulum 215
proteasome 209
colon carcinoma 204
c-myc 201
KRAS 200
MMP9 199
proto-oncogene 197
p27 194
JNK 191
PD-L1 188
osteopontin 187
metalloproteinase 185
ZEB1 178
PD-1 173
PC-3 172
mutant p53 171
RhoA 170
FAK 168
MET 167
CXCL12 165
p65 165
focal adhesion kinase 165
Slug 163
cyclooxygenase-2 162
interleukin-6 161
COX-2 159
phosphatase 159
extracellular signal-regulated kinase 158
MYC 157
survivin 156
lectin 156
GTPase 151
mucin 151
ROS 150
cadherin 149
VEGFR2 148
phosphatidylinositol 3-kinase 148
galectin-3 147
cell adhesion molecule 147
APC 145
histone deacetylase 145
membrane-bound 145
insulin-like growth factor 144
PC3 143
proliferating cell nuclear antigen 142
CD133 141
progesterone receptor 140
c-Jun 140
threonine 139
CD31 137
AP-1 136
Fas 135
CD11b 133
adhesion molecule 132
PARP 132
c-Met 130
signal transducer and activator of transcription 3 129
gut 129
ECM 126
transforming growth factor-beta 126
STAT 126
Vimentin 125
Vascular endothelial growth factor 124
BRCA1 124
CCL2 123
CD34 122
telomeric 119
Cytokine 117
inducible nitric oxide synthase 117
serine protease 116
IFN-gamma 115
erbB-2 114
prostate-specific antigen 114
smooth muscle actin 112
MDM2 112
matrix metalloproteinase 2 110
cyclin E 110
MMP2 109
cyclin 109
fused 109
Met 109
IL-2 109
AS1 109
histone H3 108
Smad2 107
bcl-2 107
EGF receptor 107
more...
Disease
tumor progression 40807
cancer 24351
tumor 24176
tumor growth 4431
breast cancer 4330
tumorigenesis 4162
metastases 3138
carcinoma 3023
carcinogenesis 2891
prostate cancer 1876
melanoma 1817
adenocarcinoma 1778
colorectal cancer 1720
hepatocellular carcinoma 1609
lung cancer 1524
squamous cell carcinoma 1233
primary tumor 935
gastric cancer 925
glioma 912
colon cancer 908
ovarian cancer 841
pancreatic cancer 772
aggressiveness 752
non-small cell lung cancer 729
tumor angiogenesis 709
glioblastoma 660
MCF 541
bladder cancer 537
renal cell carcinoma 525
tumor initiation 491
lung carcinoma 458
lymphoma 438
leukemia 407
dysplasia 390
cervical cancer 379
epithelial ovarian cancer 358
liver cancer 353
glioblastoma multiforme 343
osteosarcoma 337
brain tumor 324
adenoma 303
neuroblastoma 301
multiple myeloma 295
mammary tumor 283
obesity 273
liver cancer 266
solid tumor 265
sarcoma 261
neoplastic transformation 247
EMT 243
Hepatocellular carcinoma 239
metastatic melanoma 222
metastatic breast cancer 218
esophageal cancer 210
Barrett's esophagus 201
retinoblastoma 200
thyroid cancer 197
endometrial cancer 195
esophageal cancer 194
diabetes 194
lung metastases 178
liver metastases 178
Melanoma 177
skin cancer 175
aggression 174
SCID 172
tumor vasculature 172
B-cell lymphoma 159
oral cancer 155
astrocytoma 152
APC 147
acute myeloid leukemia 145
invasive cancer 143
mole 140
fibrosarcoma 140
bone metastases 136
cirrhosis 135
ductal carcinoma in situ 135
carcinoma in situ 135
head and neck cancer 126
ductal carcinoma 126
anemia 125
renal cancer 123
residual disease 121
Hippel 118
Glioblastoma 117
Hodgkin's disease 117
Epstein 110
AS1 109
Blocking 106
lymphatic vessels 106
hepatitis B 105
chronic myeloid leukemia 102
HGF 99
atherosclerosis 98
colitis 95
epithelial tumor 93
ATM 90
brain metastases 90
small cell lung cancer 89
transitional cell carcinoma 88
virus infection 88
meningioma 88
papillary thyroid cancer 86
cutaneous melanoma 86
mesothelioma 84
PSA 83
medulloblastoma 81
PIN 81
HCC 80
Osteosarcoma 79
thrombocytopenia 79
Osteosarcoma 79
cold 74
NOD 74
neutropenia 73
cancer recurrence 72
depression 71
papilloma 71
WT1 71
chronic lymphocytic leukemia 70
mimicry 70
rhabdomyosarcoma 68
infectious diseases 67
acute lymphoblastic leukemia 67
cardiovascular disease 66
Neuroblastoma 65
Neuroblastoma 65
familial adenomatous polyposis 65
brain cancer 64
HIV 64
Leukemia 64
hypertension 63
anaplastic astrocytoma 63
hepatitis C 62
hematologic malignancies 62
Kaposi's sarcoma 61
uterus 61
GSH 61
stromal tumors 60
Prostate Cancer 60
non-Hodgkin's lymphoma 59
chronic lymphocytic leukemia 58
AGS 57
Alzheimer's disease 57
chondrosarcoma 56
cervical intraepithelial neoplasia 55
Dukes 55
ulcerative colitis 55
ischemia 54
Ewing's sarcoma 54
uterine cervix 53
dysplastic nevi 53
Esophageal squamous cell carcinoma 53
carcinoid 52
inflammatory bowel disease 52
sepsis 52
gastrointestinal cancer 52
liver disease 52
basal cell carcinoma 51
more...
Symptom
pain 180
starvation 119
diarrhea 79
fatigue 73
nausea 66
cachexia 65
seizures 62
vomiting 59
exhaustion 54
anorexia 40
headache 38
collapse 34
abdominal pain 30
weakness 29
splenomegaly 29
acidity 28
anesthesia 27
nausea and vomiting 25
dyspnea 24
overweight 22
bone pain 21
cough 19
cancer pain 18
analgesia 15
ataxia 12
Ill 11
discomfort 10
back pain 9
discomfort 8
dizziness 7
hyperoxia 7
chest pain 7
tinnitus 7
asthenia 7
respiratory distress 6
constipation 6
chills 6
hemoptysis 6
shortness of breath 5
numbness 5
hypothermia 5
vertigo 5
myalgia 5
Stiffness 5
HSA 5
erythema 5
hepatomegaly 4
Fluctuation 4
facial pain 4
Scratch 4
spasm 4
exertional dyspnea 4
lethargy 4
dysuria 4
tremor 4
low back pain 4
ENT 4
hepatosplenomegaly 4
agitation 3
paresis 3
paresthesia 3
sleepiness 3
leg edema 3
skin damage 3
neck pain 3
flushing 3
hemiplegia 3
hypercapnia 2
Postoperative pain 2
thinning 2
hot flushes 2
abdominal discomfort 2
No adverse effect 2
clubbing 2
pelvic pain 2
syncope 2
intestinal bleeding 2
hot flashes 2
dysarthria 2
hunger 2
polyuria 2
hip pain 2
arthralgia 2
fasciculation 2
fever of unknown origin 2
flank pain 2
insomnia 2
pallor 2
oliguria 2
hypotonia 2
neuralgia 2
masculinization 1
Pain symptoms 1
hoarseness 1
incoordination 1
acute pain 1
twitching 1
Reticulocytosis 1
Tissue anoxia 1
lightheadedness 1
partial seizure 1
decreased appetite 1
urinary frequency 1
polydipsia 1
dry skin 1
colic 1
paraparesis 1
swollen joints 1
menopausal symptoms 1
adipsia 1
mastalgia 1
pleuritic chest pain 1
bloating 1
epigastric pain 1
apathy 1
CSR 1
Gastrointestinal symptoms 1
stomach pain 1
regurgitation 1
Depressive symptoms 1
stridor 1
chronic cough 1
angina 1
spasticity 1
DNA marker 1
rhinorrhea 1
productive cough 1
hyperemesis 1
distraction 1
loss of balance 1
tonic-clonic seizure 1
Anoxia 1
consciousness disturbance 1
breakthrough pain 1
acute stress 1
hopelessness 1
Perianal pain 1
blurred vision 1
torticollis 1
abdominal fullness 1
knee pain 1
memory loss 1
acute abdomen 1
Tenderness 1
dysesthesia 1
joint stiffness 1
disturbed balance 1
abdominal cramps 1
rales 1
Mills 1
tingling 1
prostatism 1
myoclonus 1
sciatica 1
painful erections 1
heartburn 1
generalized rash 1
prostration 1
Drug
lysine 206
Dermatol 187
ROS 150
CSF 112
IFN-gamma 112
IL-2 109
uPA 83
Bevacizumab 63
Monit 62
GEO 51
ROC 47
ETS 43
MAP 39
Sorafenib 39
Imatinib 38
Cardiovasc 36
Adriamycin 34
G-CSF 33
Docetaxel 28
Paraffin 28
NADH 27
Herceptin 27
ABC 27
CAM 25
Taxol 23
CPT-11 22
ascorbate 22
vitamin E 21
Gelatin 21
Gleevec 21
CTX 21
Gefitinib 20
Cetuximab 20
Activin 20
Mutagen 19
lactose 19
ICI 18
PTC 18
EE2 17
NVP 16
ADM 15
Erlotinib 15
p75 15
Heme 14
CoCl2 14
Gel 14
Retinoic acid 14
IL-11 14
CoCl2 14
Nitric Oxide 13
Estrogens 13
TAT 13
CCL 12
NBT 12
Everolimus 12
Urokinase 11
Oxaliplatin 11
ADR 11
Growth hormone 11
CTC 11
DNase I 11
CTC 11
Etoposide 10
R1881 10
Portal 10
Bortezomib 10
BLM 10
Angiotensin II 10
MRC 10
Growth hormone 9
Indomethacin 9
Glutathione 9
VCR 9
Asn 9
Lovastatin 9
Hyaluronidase 9
ENT 9
Parkin 8
caffeine 8
Irinotecan 8
CTX 8
G418 8
Parkin 8
Sunitinib malate 8
nitroglycerin 8
Hyaluronidase 7
Meth 7
Alliance 7
HCG 7
Ethanol 7
KGF 7
Dasatinib 7
RFP 7
MDS 7
CTX 7
Batimastat 6
Simvastatin 6
Vitamin E 6
TTC 6
CDP 6
Denosumab 6
Adenosine triphosphate 6
Batimastat 6
Asthma 6
Tarceva 6
Leaf 6
Fulvestrant 6
L-tyrosine 6
Vitamin A 6
Fluorescein 5
Histamine 5
Arsenic trioxide 5
Ranitidine 5
BH4 5
Lipiodol 5
Cremophor EL 5
Vitamin K 5
TEL 5
DHT 5
Doyle 5
DHT 5
Rituximab 5
PDL 5
Nexavar 4
Fraction 4
Taxotere 4
Pirfenidone 4
AMC 4
VCR 4
Doxycycline 4
FAD 4
citric acid 4
Nephron 4
Indocyanine green 4
Ginseng 4
TES 4
Albumin 4
TAK 4
Trabectedin 4
Pertuzumab 4
MTC 4
NovoSeven 4
SBT 3
BCG vaccine 3
Isotretinoin 3
Orlistat 3
Vandetanib 3
Flavopiridol 3
Raloxifene 3
Glutamic acid 3
PTH 3
IL-1ra 3
LCM 3
LCM 3
NOV 3
DM1 3
LMWH 3
Bexarotene 3
Pemetrexed 3
Ipilimumab 3
more...
Enzyme
ERK 2047
mitogen-activated protein kinase 1355
focal adhesion kinase 849
luciferase 637
protein kinase 507
MEK 305
urokinase-type plasminogen activator 253
proteasome 214
caspase-3 209
protein kinase C 192
APC 156
PARP 154
reverse transcriptase 149
phosphatidylinositol 3-kinase 148
MMP 134
collagenase 123
AMP-activated protein kinase 122
prostate-specific antigen 106
phosphoinositide 3-kinase 104
ATPase 99
thrombin 97
MMP-3 94
matrix metalloproteinase 2 88
cdc2 85
GSK 85
ACS 85
cathepsin B 83
AMPK 81
plasmin 78
trypsin 74
AMPK 74
catalase 74
calcineurin 69
RNA polymerase 67
peroxidase 67
DNA methyltransferase 66
IKK 64
glutathione S-transferase 61
P-glycoprotein 61
matrix metalloproteinase 9 60
lactate dehydrogenase 57
caspase-8 55
demethylase 55
granzyme B 54
superoxide dismutase 53
arginase 51
lysyl oxidase 49
CD10 48
matriptase 45
caspase-9 44
cathepsin D 44
RNase 43
NADPH oxidase 43
alkaline phosphatase 42
NADPH oxidase 42
RNase 40
complex I 38
furin 38
PDK1 37
aldehyde dehydrogenase 36
aldehyde dehydrogenase 36
matriptase 35
aldehyde dehydrogenase 34
aldehyde dehydrogenase 34
aldehyde dehydrogenase 34
topoisomerase 34
glyceraldehyde-3-phosphate dehydrogenase 32
cathepsin L 32
MAP 32
transcriptase 32
phospholipase C 32
hyaluronidase 31
prolyl hydroxylase 30
topoisomerase 30
ALDH 30
neuraminidase 29
DNA polymerase 29
hyaluronidase 29
NO synthase 29
tyrosinase 29
endonuclease 28
carbonic anhydrase 27
protein phosphatase 2A 27
kallikrein 27
sialyltransferase 27
firefly luciferase 26
sialyltransferase 26
kinesin 26
sialyltransferase 26
alanine aminotransferase 25
gamma-glutamyl transpeptidase 25
ornithine decarboxylase 24
NOS 24
histone demethylase 24
caspase-1 23
phosphodiesterase 23
stromelysin-3 23
pyruvate kinase 23
isocitrate dehydrogenase 22
isocitrate dehydrogenase 22
proprotein convertase 21
transglutaminase 21
glutathione peroxidase 21
TACE 21
thymidine kinase 20
beta-galactosidase 20
sialidase 20
tryptase 20
15-hydroxyprostaglandin dehydrogenase 20
MIP 19
glyceraldehyde-3-phosphate dehydrogenase 19
aspartate aminotransferase 19
lipoxygenase 19
tissue plasminogen activator 19
hexokinase 19
interstitial collagenase 18
thymidine phosphorylase 18
prostate-specific membrane antigen 18
HK2 17
renin 17
lysophospholipase D 17
N-acetylglucosaminyltransferase V 17
phospholipase A2 16
polo-like kinase 1 16
MDR 16
glyceraldehyde-3-phosphate dehydrogenase 16
succinate dehydrogenase 16
enolase 16
hepsin 16
hepsin 16
glyceraldehyde-3-phosphate dehydrogenase 16
CD13 16
indoleamine 2,3-dioxygenase 16
glyceraldehyde-3-phosphate dehydrogenase 16
neutrophil elastase 16
adenosine deaminase 15
histone acetyltransferase 15
adenosine deaminase 15
monoamine oxidase 15
MEKK1 15
ribonucleotide reductase 14
peroxiredoxin 14
SPC 14
N-acetylglucosaminyltransferase 14
CYP3A4 13
ribonucleotide reductase 13
ATP synthase 13
TAT 13
phospholipase D 13
glutaminase 13
cathepsin G 12
pyruvate dehydrogenase 12
DNase 12
legumain 12
thromboplastin 12
cathepsin K 12
O-GlcNAc transferase 11
acid phosphatase 11
fumarase 11
Alternating 11
more...
Compound
DNA 3684
Dec 2605
Clin 1635
oxygen 1096
MDA 722
tyrosine 669
glucose 497
TNM 404
calcium 363
serine 358
methionine 317
MTT 309
TNF 285
ATP 266
lysine 259
cysteine 243
MEK 228
phosphate 227
sulfate 223
threonine 209
nitric oxide 191
arginine 190
acetate 184
zinc 177
water 169
iron 149
sodium 146
ASA 140
hydrogen 138
Vimentin 125
glutamine 120
leucine 106
galactose 105
retinoic acid 104
PEG 95
GlcNAc 86
ACS 84
ACS 84
Pac 82
5-FU 81
nitrogen 79
vitamin D 79
DDP 78
PGE 78
GTP 76
cAMP 75
AMP 72
alanine 71
anthracene 70
SCC 70
GSH 68
GSH 68
iodine 67
tryptophan 67
hyaluronic acid 67
bromide 67
proline 64
THP 62
ethanol 62
THP 61
glutamate 60
PEG 60
urea 59
Curcumin 58
DBA 58
Estrogen 58
Estrogen 57
PGE2 57
Insulin 56
PMA 56
Asp 55
copper 54
Thyroid 53
BCNU 51
potassium 51
His 50
NAD 50
tryptophan 49
tryptophan 48
tryptophan 48
Adriamycin 48
Histone 47
Collagen 46
formaldehyde 46
H2O2 45
Metformin 44
Metformin 44
Gly 43
ADP 42
NAD 41
nicotinamide 41
TOF 40
ABL 40
NADPH 39
Androgen 39
NADPH 39
CAM 38
BCR 38
boron 38
pyrene 37
NH2 37
Phe 37
selenium 37
COX 36
N-acetylcysteine 36
ADP 35
MAP 35
ADP 35
MIA 35
ADP-ribose 35
Ubiquitin 34
Serine 34
pentose 33
pentose 32
Sphingosine 32
DFS 32
pentose 32
ADR 32
pentose 32
SDS 32
DCC 31
BCG 31
Paclitaxel 30
Resveratrol 30
pyrimidine 30
GalNAc 30
dUTP 30
pyrimidine 30
VP-16 30
adenosylmethionine 29
Cysteine 29
DSS 29
2-oxoglutarate 28
CCNU 28
Tyrosine 28
Lactate 28
Rapamycin 27
NADH 27
PMA 27
CO2 27
Adenosine 27
Gemcitabine 26
silver 26
Gemcitabine 26
GDP 26
TPA 25
TPA 25
CAT 25
CAT 25
CAT 25
Docetaxel 24
salt 24
glutamic acid 24
Melatonin 24
TEM 23
Heparan sulfate 23
Vitamin D 22
DBA 22
CPT-11 22
DBA 22
more...