Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0178874 (
tumor progression
)
40,807
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer. Hydroxysteroid dehydrogenase like 2 (
HSDL2
) can regulate lipid metabolism and take part in cell proliferation. The purpose of the present study was to explore functional role of
HSDL2
gene in PTC. The expression of
HSDL2 protein
in PTC tissues was estimated using immunohistochemistry analysis (IHC).
HSDL2
mRNA level was detected through quantitative real-time polymerase chain reaction (qRT-PCR). Effects of
HSDL2
gene on cell proliferation and apoptosis were assessed using the shRNA method for both
in vitro
and
in vivo
experiments. Potential target genes of
HSDL2
were determined via bioinformatics analyses and Western blotting.
HSDL2
was up-regulated in PTC tissues and cell lines compared with the controls (all
P
<0.05). Inhibiting HSDL expression could suppress PTC cell proliferation and cycle, and promote apoptosis
in vitro. In vivo
, the knockdown of
HSDL2
gene could significantly suppress tumor growth (all
P
<0.05). Furthermore,
AKT3, NFATc2
and
PPP3CA
genes might be potential targets of
HSDL2
in PTC.
HSDL2
expression was increased in PTC tissues and cells, which could promote
tumor progression
in vitro
and
in vivo
.
...
PMID:Down-regulated
HSDL2
expression suppresses cell proliferation and promotes apoptosis in papillary thyroid carcinoma. 3110 84
