Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0178874 (
tumor progression
)
40,807
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Retinoblastoma-binding protein 7
(
RBBP7
) is an important component of several complexes that regulate chromatin metabolism. It is overexpressed in certain cancer types and serves conflicting roles in
tumor progression
. In the present study, the expression and roles of
RBBP7
were explored in esophageal squamous cell carcinoma (ESCC). Immunohistochemical staining was used to detect
RBBP7
expression in ESCC tissues. The mRNA sequencing profiles from the Cancer Genome Atlas and Genotype-Tissue Expression databases were mined to analyze the mRNA expression of
RBBP7
in tissues. Proliferation, clone formation, apoptosis and Transwell invasion/migration assays were performed to explore the roles of
RBBP7
in ESCC.
RBBP7
was highly expressed in ESCC tissues. The protein and mRNA expression levels of
RBBP7
were significantly elevated in tumor tissues compared with paired adjacent normal tissues.
RBBP7
overexpression was associated with a poor overall survival in patients with ESCC. Furthermore, higher
RBBP7
expression was significantly correlated with poor tumor differentiation, advanced regional lymph node involvement, and pathological TNM staging. Knockdown of
RBBP7
in ESCC cells did not affect tumor apoptosis or tumor growth. However, the overexpression of
RBBP7
significantly enhanced the invasion and migration of ESCC cells, whereas the knockdown of
RBBP7
resulted in significantly decreased invasion and migration. The present study indicated that
RBBP7
is a novel biomarker and prognosticator for patients with ESCC. Furthermore,
RBBP7
serves crucial roles in promoting ESCC invasion and migration.
...
PMID:RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma. 3054 58
