Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Pivot Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Target Concepts:
Gene/Protein
Disease
Symptom
Drug
Enzyme
Compound
Query: UMLS:C0178874 (
tumor progression
)
40,807
document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)
Kinesin family member C1
(
KIFC1
) is a minus end-directed motor protein that plays an essential role in centrosome clustering. Previously, we reported that
KIFC1
is involved in
cancer progression
in prostate cancer (PCa). We designed this study to assess the involvement of
KIFC1
in docetaxel (DTX) resistance in PCa and examined the effect of
KIFC1
on DTX resistance. We also analyzed the possible role of a
KIFC1
inhibitor (CW069) in PCa. We used DTX-resistant PCa cell lines in DU145 and C4-2 cells to analyze the effect of
KIFC1
on DTX resistance in PCa. Western blotting showed that
KIFC1
expression was higher in the DTX-resistant cell lines than in the parental cell lines. Downregulation of
KIFC1
re-sensitized the DTX-resistant cell lines to DTX treatment. CW069 treatment suppressed cell viability in both parental and DTX-resistant cell lines. DTX alone had little effect on cell viability in the DTX-resistant cells. However, the combination of DTX and CW069 significantly reduced cell viability in the DTX-resistant cells, indicating that CW069 re-sensitized the DTX-resistant cell lines to DTX treatment. These results suggest that a combination of CW069 and DTX could be a potential strategy to overcome DTX resistance.
...
PMID:KIFC1 Inhibitor CW069 Induces Apoptosis and Reverses Resistance to Docetaxel in Prostate Cancer. 3074 26
Hepatocellular carcinoma (HCC) is a common type of malignant tumor worldwide with a high mortality rate. In the past 20 years, the morbidity rate of HCC has increased. Progress has been made in the clinical diagnosis and therapy for HCC. However, due to the high heterogeneity and metastasis targeted therapy for HCC exhibits great promise, and novel therapeutic targets for HCC are urgently required.
Kinesin family member C1
(
KIFC1
) is a member of the kinesin superfamily of proteins. Previous studies have indicated a potential association between
KIFC1
and
cancer progression
. However, the potential role of
KIFC1
in the development of HCC remains unclear. The present study aimed to explore the function of
KIFC1
in HCC. Immunohistochemical (IHC) assays were performed to explore the KIF15 expression levels in 74 samples of HCC and corresponding non-tumor tissues. The potential association between KIF15 expression levels and clinical features was analyzed, and the effects of KIF15 on cell proliferation of HCC were detected by colony formation and MTT assays. In addition, the proliferation-related proteins Ki67 and PCNA were detected by western blotting. The possible effects of KIF15 on tumor growth were measured in mice. The results demonstrated that a high expression level of
KIFC1
was associated with poor prognosis of HCC. Further results indicated that
KIFC1
promoted cell proliferation of HCC
in vitro
. In addition, knockdown of
KIFC1
suppressed tumor formation and growth in mice. Therefore, these results provide a potential therapeutic target for the treatment of HCC.
...
PMID:KIFC1 promotes the proliferation of hepatocellular carcinoma
in vitro
and
in vivo
. 3178 47
